Incyte Arc Expert

The Incyte Arc Expert sensor enables in-line, real-time viable cell density measurement, essential for achieving data-driven process optimization and control in bioprocessing.

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  • Incyte Arc Viable Cell Density sensor

Incyte Arc Expert Details

Hamilton’s  Incyte Arc sensors enable real-time, in-situ measurement of viable cells. The measurement is not influenced by changes in the media, microcarriers, dead cells, or debris.

Permittivity is quickly becoming the industry standard for the measurement of viable cell volume because of its robust real-time data. It correlates well to off-line cell counting in the crucial exponential phase without the risk of counting errors. Incyte Arc sensors provide a real-time measurement of viable cell density with continuous permittivity data. 

Offline samples only provide limited, error-prone data points, so process events may be missed. Real-time permittivity reveals changes in cell physiology, so advanced process control can be automatically triggered for process optimization.

Common applications Cell Biology, Cell Culture, Pharma & Biopharma, Bioprocess Upstream, Biotechnology

Compare permittivity data to ensure batch-to-batch and scale-up reproducibility.

Gain process insights such as cell physiology changes with permittivity measurement.

 Time key process events for lower cost, increased yield, & enhanced product quality.

Viable Cell Density Soft Sensor

AADM calculates real time viable cell density that correlates to off-line measurement and closes all gaps between the measuring points.

Easy Transmitter-less

  • Hamilton Arc technology enables seamless integration to a control system, PLC, or DCS without a bulky transmitter.
  • Leverage the Arc platform to perform maintenance and configuration with ArcAir™ software.
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Use case

How It's Used

Monitor viable cell density in real time and identify critical growth phase transitions before they affect process performance. Gain deeper process insights and implement data-driven optimizations to protect yield, improve reproducibility, and scale with confidence.

Scientific Citations

  • The difference in measurement resolution between the off-line method and permittivity is like between a 60's TV and an 8K screen!

    We used the Incyte Arc Sensor to monitor the viable cell density. It is very easy to install in a bioreactor and connect to the monitoring software. After performing a baseline calibration in medium, you are ready to monitor your bioreactor run.

    Jort Altenburg, Ph.D
    Wageningen University, Netherlands

  • I could not be more pleased with my experience with Hamilton!

    My company has been using Hamilton probes for years and have always been happy with their performance! The team is always very helpful in trouble shooting issues and answering any questions that we may have about our probes. Overall, I could not be more pleased with my experience with Hamilton!

    Abigail Mann
    Bioprocessing Fermentation Associate at Heliae Development

Incyte Arc Expert Specifications

Print
Process Connection PG13,5
Wetted Parts Platinum
Stainless Steel 1.4435
PEEK (Polyetheretherketone)
EPDM (Ethylene propylene elastomer)
Electrical Connector VP8
Parameter Viable Cell Density
Sensor Output Arc: Modbus
Measuring Range 0 to 700 pF/cm, equivalent to 5 x 10^5 to 8 x 10^9 cells/mL (mammalian)
Precision at 25 °C Permittivity (at 1 MHz): ± 1 pF or ± 1 %
Whichever value is greater over the entire measuring range
Accuracy at 25 °C Conductivity (at 0 pF): ± 25 µS or ± 1 %
Whichever value is greater over the entire measuring range
Temperature Sensor Yes
Configurable Values VCD, Conductivity, Temperature
O-ring Material EPDM (Ethylene propylene elastomer)
Surface Quality of Steel Ra < 0.4 µm (N5)
Digital Interface RS485 Modbus (max. 32 addresses)
Baud Rate 19200, 38400, 57600,115200 Bd
Operating Voltage 24 V (± 10 %)
Serial Number Yes
Certificate Yes
Diameter 12 mm
Autoclavable Yes (30-minute sterilization duration, for Revision 00: 130°C, for Revision ≥ 01: 140°C)
Steam Sterilizable Yes (140°C, 30-minute sterilization duration)
CIP Yes (3% NaOH, 90°C, 30-minute cleaning duration)
Operating Temperature Range 0 to 60 °C
Conductivity Range 1 to 80 mS/cm for firmware below CDCUM003
0.5 to 80 mS/cm for firmware CDCUM003 and above (with Hamilton calibration)
Pressure Range bar g 0 to 12 bar
Resolution at 25 °C 0.1 pF/cm
Max. Accuracy Conductivity (at 0 pF): ± 100 µS (for whole operating temperature range)
Max. Precision Permittivity (over all frequencies): ± 1 pF (for whole operating temperature range)

Compatibility with Hamilton Devices.

Explore the limitless possibilities of Hamilton products.

Incyte Arc Expert Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Infographic showing a bioreactor connected to four benefits: Historical Process Data, Reduce Offline Sampling, Offline Data in Realtime, Better Process Overview.

Article

Data Logging Options for Incyte Arc Cell Density Sensors Before Update 3.6

There are two options to capture data with Incyte Arc Cell Density Sensors. This article provides step-by-step instructions on each.
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Article

Incyte Cell Density Measurement Principles

Incyte enables the dual frequency measurement mode, or a frequency scanning. Learn about how Hamilton Incyte cell density sensors can continuously measure viable cells.
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Article

Arc Sensors - Signal Averaging

Certain applications may introduce conditions that create fluctuating or "noisy" measurements. The noisy measurement can make process control challenging. One way to improve signal stability is to adjust the moving average setting using ArcAir software.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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FAQ

How does Incyte measure viable cell density?

Incyte is a capacitance-based sensor responsive only to living cells.
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FAQ

What effect will bubbles have on the Incyte sensor measurement?

Gas bubbles have two main impacts: (1) Decreased signal intensity since the sensor cannot measure in air. (2) Increased background noise.
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FAQ

Will Incyte work with my cell line?

Incyte has been shown to work with cell lines ranging from cell culture to microbial fermentation. We have compiled a current list of known applications in our cell density applications ebook. Download a copy to learn more.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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Webinar

Maximize Yield with Real-Time Cell Density Monitoring

This webinar explores the application of real-time monitoring techniques in cell culture and bioprocessing, focusing on electrical permittivity and near-infrared (NIR) turbidity measurements.
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Application and Technical Support

Hamilton's Technical Support team is here to provide product trouble-shooting, repair, application support, virtual start-up support, and more.

Installation Support

Installation, set-up, and calibration support directly on-site. Our field service team ensures your sensors and cables are installed and functioning correctly.

Maintenance and Calibration Services

Preventative maintenance and regular service contracts. Schedule on-site service dates to ensure your sensors are properly maintained and your process is optimized.

On-Site Service Diagnostics

Diagnosing and resolution of process system problems on-site. Finding the root cause and presenting a solution to fit your needs.

On-Site Training

User trainings and on-site trainings for technicians. Tailored training ranging from basic operation to advanced calibration and maintenance.

Qualification IQ/OQ

Support for the qualification of Hamilton equipment including complete documentation. Readying your process for GMP manufacturing activities.

Modular Service Contracts

Hamilton offers modular service contracts tailored to your requirements, featuring a basic module complemented by optional add-ons.

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