CO₂NTROL RS485

Hamilton's CO₂NTROL RS485 is a solid-state sensor that directly measures dissolved CO₂ and provides maintenance-free, real-time, and in-line control of this critical process parameter.

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  • CO2NTROL CO2 Sensor

CO₂NTROL RS485 Details

Hamilton's CO₂NTROL solid-state sensor offers maintenance-free, real-time, in-line dissolved CO₂ measurement, enabling automated control for improved titer, batch consistency, and scalability from R&D to production bioreactors. 

Traditional electrochemical sensors measure DCO₂ based on the Severinghaus principle. This indirect measurement method combines the challenges of measuring pH and electrochemical DO into one sensor. The result is significant maintenance effort and multiple sources of drift that must be compensated for by time-consuming product calibration.

Common applications Pharma & Biopharma, Bioprocess Upstream, Water, Energy, & Environment, Water and Wastewater, Chemical Processes

Simple sensor calibration in air and gas.

Maintenance-free, requiring no liquid or part replacements, saving cost and time.

The measuring range is designed for bioproduction applications, covering 5 to 1000 mbar.

Integrated Intelligence

Arc sensors save space and cost with integrated micro-transmitters that store calibration and sensor quality data.

Compliant Hygienic Design

The hygienic design makes it compliant with requirements of biopharma applications.

Co2 use case
Use case

How It's Used

Real-time Monitoring of DCO2 in addition to DO

Using Hamilton’s CO₂NTROL and VisiFerm sensors, this study demonstrates how continuous, in-line data collection provides deeper insights into cell metabolism and allows for rapid adjustments to maintain optimal conditions. From observing metabolic activity to managing key parameters like viable cell density and glucose levels, the findings highlight the impact of real-time data on enhancing process control and productivity.

References

Real Time DCO2 and DO mAb production

Application Note - Real-time Monitoring of DCO₂ in Addition to DO

In this application note, the utilization of a DCO₂-probe…

Scientific Citations

  • I could not be more pleased with my experience with Hamilton!

    My company has been using Hamilton probes for years and have always been happy with their performance! The team is always very helpful in trouble shooting issues and answering any questions that we may have about our probes. Overall, I could not be more pleased with my experience with Hamilton!

    Abigail Mann
    Bioprocessing Fermentation Associate at Heliae Development

  • Great opportunity for us to engage in discussions with Hamilton experts.

    For us and our bioprocesses, it was crucial to learn more about optical sensors (O2, CO2) and exchange experiences in troubleshooting. The online seminar was a great opportunity for us to engage in discussions with the experts from Hamilton.

    Patrick Berthel
    Technical Assistant, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie, Jena, Germany

CO₂NTROL RS485 Specifications

Print
Process Connection PG13,5
Wetted Parts Stainless Steel 1.4435
EPDM (Ethylene propylene elastomer)
VMQ (Silicone elastomer)
See compliance details in Material Specification document
Electrical Connector VP8
Parameter DCO₂ (Dissolved CO2)
Measuring Range 5 - 1000 mbar or 0.5 - 100 % vol or 7.5 - 1500 mg/L in liquid phase at 101.3 kPa and 25°C
Electrolyte None
Accuracy at 25 °C ±5 mbar (5-100 mbar); ±5% (> 100 mbar)
CO₂ Consumption None
Temperature Sensor NTC 22 kOhm
Configurable Values Dissolved CO2 (dCO2): mbar, mmHg, hPa, %-vol, %-sat, µg/l ppb, mg/l ppm; Temperature: K, °C, °F
Surface Quality of Steel Ra < 0.4 µm (N5)
Digital Interface RS485 Modbus (max. 32 addresses)
Baud Rate 4800, 9600, 19200, 38400, 57600, 115200 Bd
Operating Voltage 10 to 27 VDC
Serial Number Yes
Certificate Yes, factory calibration with CO₂ certified gas
Hygienic Design Approval EHEDG approved. EL Class I. (Test executed with Hamilton hygienic socket REF 242545)
ATEX Approval No
IECEx Approval No
Diameter 12 mm
Autoclavable Yes (140°C, 30-minute sterilization duration)
Steam Sterilizable Yes (140°C, 30-minute sterilization duration)
CIP Yes (3% NaOH, 90°C, 30-minute cleaning duration)
Operating Temperature Range -10 to 140 °C; the sensor provides no CO₂ reading above 60 °C
Pressure Range bar g -1 to 12 bar
Protection Rating IP68
Required Flow None

Compatibility with Hamilton Devices

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CO₂NTROL RS485 Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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Article

CO₂NTROL RS485 Sensor Calibration

Since CO2 measurement can be a new parameter for some users this article provides some basic question and answer topics related to calibration of this sensor.
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Article

Arc Sensors - Signal Averaging

Certain applications may introduce conditions that create fluctuating or "noisy" measurements. The noisy measurement can make process control challenging. One way to improve signal stability is to adjust the moving average setting using ArcAir software.
Hamilton Sensor in packaging

Article

Documentation and Certificates for Sensors and Liquid Solutions

What documentation and certificates can I expect with my sensor or probe? This article provides examples of the types of paper documents that normally come with Hamilton products.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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FAQ

What spare parts are needed for the CO₂NTROL Sensor?

The CO2NTROL Sensor is completely sealed has no spare parts requirements for general operation. The EPDM o-ring seal on the exterior of the 12mm shaft is replaceable (Ref 254170).
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FAQ

Is the CO₂NTROL CO₂ sensor sanitary?

The tip of the CO2NTROL sensor has round "dots" that give the appearance of perforated metal. This surface is actually smooth. It is covered with a layer of translucent silicone that ensures a sanitary design. In fact, the design meets EHEDG sanitary requirements and has been certified.
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FAQ

What is A-length and how is it measured?

A-length refers to the insertion depth of the sensor. It's generally measured from the base of the PG13.5 mounting threads but can vary with certain styles of sensors.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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Webinar

Improved Process Robustness Through In-line DCO2 Measurement

This webinar in collaboration with Biostream International discusses the importance of measuring dissolved carbon dioxide (DCO2) in your bioprocess. DCO2 is a critical process parameter (CPP) in biopharma production processes according to PAT guidelines
Two lab professionals in white coats reviewing documents in a laboratory setting.

Webinar

Is Your Process In CO2NTROL?

Dissolved carbon dioxide (DCO₂) is a critical process parameter (CPP) in biopharma production processes according to PAT guidelines. In this webinar we will discuss why its important and how you can quickly implement this process into your workflow.
Services
Modular Service Contracts

Hamilton offers modular service contracts tailored to your requirements, featuring a basic module complemented by optional add-ons.

Installation Support

Installation, set-up, and calibration support directly on-site. Our field service team ensures your sensors and cables are installed and functioning correctly.

Qualification IQ/OQ

Support for the qualification of Hamilton equipment including complete documentation. Readying your process for GMP manufacturing activities.

Maintenance and Calibration Services

Preventative maintenance and regular service contracts. Schedule on-site service dates to ensure your sensors are properly maintained and your process is optimized.

On-Site Service Diagnostics

Diagnosing and resolution of process system problems on-site. Finding the root cause and presenting a solution to fit your needs.

On-Site Training

User trainings and on-site trainings for technicians. Tailored training ranging from basic operation to advanced calibration and maintenance.

Backed by world-class service and support.

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