MassXtract STAR

Sample prep
2-IN-1
Workflows
Maximize
COMPACT
Bench space
Specialized framework
VENUS
Rapid method development

Streamline Mass Spec Sample Preparation

MassXtract STAR combines all the tools you need to fully automate solid-phase extraction and protein precipitation workflows, or both, on one platform.

Mass Spec Sample Prep Simplified

MassXtract STAR is a fully automated mass spectrometry sample prep solution to ease solid-phase extraction and protein precipitation, and liquid-liquid extraction workflows.

MassXtract STAR features exclusive Fluid Motion channels and CO-RE II (Compressed O-Ring Expansion Technology). By integrating useful tools on the platform deck, workflow steps are consistently performed without taking up your time or attention.

Everything is controlled through our intuitive, user-friendly VENUS Software. From basic to highly nuanced methods, a specialized framework helps to speed your development pace.

Common applications Pharma & Biopharma, Drug Discovery, Gene and Cell Therapy, Bioprocess Downstream, Microbial Strain and Fermentation Development

Featured Technologies

Hamilton Innovation Starts at the Channel

Liquid Handling Technology

  • MAD - Monitored Air Displacement

    For Unmatched Reliability

    MAD monitors the air displacement in each pipetting channel of a Hamilton automated liquid handler. During liquid aspiration steps, this non-contact technology immediately identifies clots, empty wells, or other aspiration issues. It also delivers a confirmation of successful aspiration in each pipetting channel of a Hamilton automated liquid handler.

    Diagram showing three pipette tip states—Normal, Empty, and Clogged—each with a corresponding pressure curve graph.

  • Dual Liquid Level Detection (LLD)

    For Accurate Aspirations

    Dual LLD uses two sensors on each liquid handling pipetting channel. A capacitance sensor detects aqueous and conductive liquid surfaces while a pressure-based sensor works with non-conductive, viscous, and volatile liquids. Together, they ensure highly accurate and reliable liquid handling performance.

    Infographic showing 3 common pipetting issues: vessel overflow, over aspiration, and liquid on outside the tip

  • Anti-Droplet Control (ADC)

    For Drip-Free Pipetting

    Pressure sensors on Hamilton’s pipetting channels continuously detect variations. Any changes are immediately compensated for by dosing drive movements to prevent droplet formation. Essential for high-precision and accuracy when pipetting volatile liquids like ethanol and acetonitrile.

    Syringe diagram with plunger, pressure sensor, and volatile liquid labels; graphs showing pressure over time with droplet and oscillation patterns.
  • Pipetting Technology
    Fluid Motion Technology

    More Workspace. More Performance. More Value.

    Innovative drive system enhances the utilization of deck space, enabling researchers to automate more scientific experiments seamlessly within a single unit, ultimately saving valuable lab space.

  • Pipetting Technology
    DPS - Dynamic Positioning System

    For Efficient Movements

    DPS enables all channels to pipette simultaneously, even across non-uniform patterns. Unlike fixed channels with equidistant spreading, DPS offers efficient yet flexible liquid handling for cherry picking, non-uniform and variable volume samples, and complex pipetting workflows.

  • Pipetting Technology
    CO-RE II Tip/Tool Attachment

    The Key to Liquid Handling Workflow Excellence

    The new CO-RE II technology assures more precise tip alignment, minimizing the risk of collisions. Also, tip coupling is faster which boosts productivity. Besides tips, a wide range of Hamilton tools are applicable with CO-RE II.

  • Accessories
    Autoload

    For Convenient Identification

    Uses a 1D barcode scanner to automatically identify and verify samples, carriers, and consumables such as tips, tubes, micro plates, and reagent troughs as they are placed onto the liquid handling deck. 2D barcode reading is available, and results may be sent to any LIMS for documentation.

  • Transport Solutions
    Quad CO-RE Grippers

    For Additional Movements

    Transform four CO-RE pipetting channels into labware transport tools for plates and consumables to improve walkaway time and support consistent positioning.

Automate protein precipitation and SPE while conserving bench space.

Configure deck positions around your labware and workflow using Multiflex Baseplates, with open deck space for additional capabilities. Start with centrifugation for protein precipitation, then adapt as needs change by adding [MPE]2 for SPE, additional carriers, magnets, or cooling options.

Reduce manual variability in pipetting, timing, temperature, and sample handling while improving traceability. 

  • VENUS 6.4.0.1914 software home screen showing a Microlab STAR instrument status as Idle with Run History entries
  • Hamilton STAR 2 automated liquid handler with MPE² module, pipetting arm, microplates, and deck accessories
  • Hamilton STAR automated liquid handler with MPE² module, pipetting arm, microplates, and a centrifuge highlighted with a green number 3 badge
  • Hamilton STAR automated liquid handler with MPE² module, pipetting arm, microplates, and deck accessories
  • Hamilton STAR automated liquid handler with MPE² module, pipetting arm, microplates, and heater shaker units on deck
  • Hamilton STAR automated liquid handler with MPE² module, microplates, tip racks, and a robotic pipetting arm labeled 6

Explore the MassXtract STAR

1

VENUS Software

User-friendly yet impactful with remote monitoring, specialized framework, and integration with most lab information management systems (LIMS) and third-party software.
2

Microlab STAR

Microlab STAR automated liquid handler offers a compact footprint and includes our CO-RE II technology to ensure reliable, safe liquid handling.
3

On-Deck Centrifuge

Spin many labware types up to 60 mm high, with a maximum g-force of 2000 x g.
4

[MPE]²

Automate solid phase extraction workflows with positive pressure and optional evaporation and reagent dispensing modules.
5

Heater Shaker Cooler

Accelerate precipitation with shaking up to 2500 RPM and heating up to 105 °C. Maintain processed sample plates at controlled temperatures between steps or after completion. 

6

Fluid Motion Technology

Maximize deck space and throughput with a streamlined drive system that enables faster pipetting and greater workflow flexibility.

MassXtract STAR Specifications

MassXtract STAR Specifications

Print

System Dimensions

Height
90.1 cm (2 ft, 11.47 in)
Width
1.67 m (5 ft, 5.75 in)
Depth
1.01 m (3 ft, 3.69 in)

Platform Type

Standard Enclosed
Standard

Transport Tools

CO-RE Gripper
Quad CO-RE Gripper

Platform/Accessories

Capacity (ANSI/SLAS Positions)
25 (With [MPE]² Integration)
Device Integration
Hamilton Heater Shaker
Hamilton Heater Cooler
[MPE]²
Vaccum Station

Sample Loading and Tracking Options

Sample Loading
Automatic, Continuous
Autoload Barcode Scanner (1D)
Standard
Autoload Barcode Scanner (2D)
Standard

Pipetting Options

Fluid Motion X1 Channels - 1000 µL
8
Pipetting Range 1
1 µL - 1000 µL

1 Depending on Configuration

MassXtract STAR Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Hamilton webinar

Webinar

Automating Protein Purification: How Hamilton & Biotage Can Boost Efficiency

Learn how automating protein purification workflows can improve laboratory efficiency and reproducibility
Hamilton MassXtract STARlet automated liquid handler

Webinar

Overcoming Mass Spec Sample Prep Challenges with the MassXtract STARlet

How MassXtract utilizes Hamilton’s integrated devices for a complete automated walkaway solution.
Two professional headshots of webinar speakers on a dark teal network graphic background

Webinar

Standardize Cell Culture. Advance Your Science: A New Approach to Automated T-Flask Workflows

Discover a new approach to automated T-flask workflows that standardizes cell culture, improves reproducibility, and frees scientists to focus on advancing their research.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Hamilton MassXtract STAR automated liquid handler with Fluid Motion Technology for mass spectrometry sample prep, shown open with MPE module and deck loaded with labware

Flyer

MassXtract STAR with Fluid Motion Technology

Explore MassXtract STAR with Fluid Motion Technology for high-throughput protein precipitation and optional solid-phase extraction.
Hamilton logo and text reading "Revolutionizing Automated Cell Culture with Cell Care STAR"

Application Note

Revolutionizing Automated Cell Culture with Cell Care STAR | White Paper

Download the white paper to explore Cell Care STAR’s system architecture, validated use cases, and future development roadmap.
Hamilton Cell Care STAR application note cover: automated cell assay set-up for throughput and reproducibility

Application Note

Cell Care STAR | Seeding from Trough

We demonstrate the advantages of automated cell culture using the “Seeding from Trough” method (work step) within Cell Control, applied to two commonly used cell types: HeLa and T47D.
Services
Installation & Beyond

Trust in Hamilton’s Field Service Engineers for high-quality automated liquid handler installation, preventative maintenance, and field repairs.

Backed by world-class service and support.

For over 75 years, the Hamilton name has been recognized globally for its unwavering commitment to quality. That pledge extends to creating long-term customer partnerships. We're proud to offer in-depth training courses, on-site field support, custom product builds, and so much more.

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