Viable Cell Density Sensors
More Data, More Control, More Possibilities
Continuous on-line, or in-situ, data allows for real-time process control. With off-line data, decisions can only be made at the time of sample analysis, resulting in imprecise timing or missing events entirely. Permittivity measurement is quickly becoming the industry standard because of the robust real-time data. It correlates well to off-line cell counting in the crucial exponential phase without the risk of counting errors. Incyte Arc sensors can be used to increase process quality across many cell lines, process types, and scales. Learn what Incyte can do for you with integration facilitated by the Hamilton Applications team.
Incyte Arc
Introducing Incyte Arc
Incyte Arc is Hamilton's next-generation viable cell density sensor, offering high-fidelity permittivity measurements but now paired with integrated microtransmitters that leverage ArcAir technology.
Existing Incyte (Pre-Amp version) sensors will continue to be supported. To get documentation or re-order sensors, visit the Incyte (Pre-Amp version) page.
Will Hamilton Cell Density Sensors Work with My Process?
Review Hamilton's Cell Density Applications Ebook
Hamilton cell density sensors are compatible with many types of cell lines and microbial strains, process types, and industries. Read more below or download our Cell Density Applications eBook to see real data with different cell lines and process types.
Start a Conversation
After starting a conversation with a Hamilton's team member, you will have access to an applications specialist to discuss the potential of Hamilton Incyte Arc sensors in your bioprocess
The Power of Permittivity
Permittivity measurements are the most reliable method of monitoring viable cell density. This measurement is immediately affected by changes in viable cell density and can be used to time process-specific actions for maximum yield. Permittivity can also be used to detect changes in cell physiology and is the most immediate method for determining the beginning of the cell death phase.
Continuous Data
Incyte Arc sensors provide a real-time measurement of viable cell density with continuous permittivity data. Off-line samples only provide limited, error-prone data points, so process events may be missed. Real-time permittivity reveals changes in cell physiology, so advanced process control can be automatically triggered for process optimization.
Incyte In Action
From increasing yield to shortening process time, the real power of permittivity is in your hands. As shown in the examples below, ask yourself what you could do with continuous process data.
Process understanding
Expand your PAT capabilities with permitivity and gain process insights such as cell physiology through use of multi-frequency scan.
Automated control
Precisely time key process events such as feeding, induction, and harvest for lower production cost, increased yield, and enhanced product quality.
Consistent quality
Compare permittivity data to ensure batch-to-batch and scale-up reproducibility.
Continuous process improvement
Gather on-line viable cell density data every run to enable continuous optimization.
Process optimization
Real-time data means never missing a key process event. Use this data to develop enhanced process decisions for increased efficiency and prolonged productivity. Alternatively, use ArcAir Data Modeling software for real-time understanding of legacy off-line counts.
Leverage Hamilton Expertise
Utilize Hamilton’s Application Team and proven evaluation process for rapid implementation and robust product evaluation.
Hamilton Application Team Support
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Incyte Setup
Hamilton evaluates your application to recommend quick-start measurement settings.
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Collect Data
Follow Hamilton’s standard protocol to ensure robust and reliable data sets.
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Analyze Results
Hamilton’s Application Team can support your analysis and generate a comprehensive report with useful insights.
Resources
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Catalog - Process Analytics
Download the Process Analytics sensor catalog to learn about the complete offering of Hamilton process sensors and accessories. -
Brochure - Arc Intelligent Sensors
Arc Intelligent sensors offer a new way to connect to your process control system. -
Manual - Incyte Arc Sensors
Manual for Incyte Arc Sensors
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How often do Incyte sensors (pre-amp version) need to be calibrated?
Hamilton recommends once per year with a validation at 6 months. -
How does Incyte measure viable cell density?
Incyte is a capacitance-based sensor responsive only to living cells. -
What effect will bubbles have on the Incyte sensor measurement?
Gas bubbles have two main impacts: (1) Decreased signal intensity since the sensor cannot measure in air. (2) Increased background noise.
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Incyte Cell Density Measurement Principles
Learn about how Hamilton Incyte cell density sensors can continuously measure viable cells. Incyte enables the dual frequency measurement mode, or a frequency scanning. -
Connecting Cell Density (Pre-amp Versions) to External Systems
This article discusses the various options to output cell density measurement data to external devices such as PLCs and control systems. -
Incyte Arc PCS Connections for Existing Cell Density Users
This article reviews changes in the sensors connection strategy between the older pre-amp version of Incyte products and the newer Incyte Arc products.
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