scientists working with a bioreactor

Sensor Solutions for Biopharma Upstream Process

The biopharma upstream process initiates the growth of microbes and cells, sourced from bacterial or mammalian cell lines. The cultivation and expansion of these entities are facilitated by the addition of nutrients, growth hormones, or specialized cell culture media into the bioreactor.

Hamilton's sensor solutions ensure real-time, reliable measurements of Critical Process Parameters (CPPs) and Key Performance Indicators (KPIs). From the intricacies of cell growth to the complexities of fermentation control, our sensors empower you to make data-driven decisions, ushering in a new era of efficiency and precision in upstream processes

Sensors and Accessories for Critical Process Parameters in Upstream

At Hamilton, we understand the importance of precise process control at each step of the upstream process to ensure optimal product quality and safety. That's why we specialize in in-line sensors and accessories that enable you to measure Critical Process Parameters (CPPs) like pH, Conductivity, Dissolved Oxygen, and Key Performance Indicators (KPIs) such as Total Cell Density and Viable Cell Density in real-time, eliminating the need for manual off-line sampling. Our sensors in combination with our housings are compatible with a wide range of systems, making them a versatile and flexible solution for any biopharmaceutical manufacturer.

Take a look at the Upstream Process below and discover what measuring solutions Hamilton has to offer:

Biopharma Upstream process

Benefits of using Hamilton Sensors

Complete product portfolio

Complete Portfolio

Measure Critical Process Parameters (CPPs) and Key Performance Indicators (KPIs) which enable the holistic understanding and control of your process

Seamless integration

Seamless Integration

Minimize the time and effort required to procure, validate, and effectively utilize a Hamilton sensor

High quality products

Highest Quality / Ready for GMP compliance

Benefit from products with the highest manufacturing standards to meet or exceed all FDA and GMP regulatory requirements

Know how

Process Analytics Know-how

Hamilton provides 30+ years of experience of process sensors developed for biopharma applications

The Power of Arc Intelligent Sensors

Hamilton’s Arc intelligent sensors redefine the relationship between sensors and transmitters, opening a wide range of operational process improvements and cost reduction. Arc intelligent sensors provide advanced alarms, troubleshooting, quality indicators, and diagnostics simultaneously to the control system and to an optional mobile device. An integrated micro-transmitter eliminates a point of failure by directly connecting the sensor to the PCS.

Learn more about ArcAir


How does PAT apply to the Bioreactor?

Download our comprehensive white paper and explore what PAT means in Biopharma Upstream processes. Discover cutting-edge solutions to effectively monitor critical process parameters and ensure product quality.


GET THE WHITE PAPER

Download Related Brochures & our Product Catalog

biopharma brochure

Biopharma Brochure

Hamilton offers the biopharmaceutical industry more measurement parameters and less measurement error, yielding tighter process control. Take a look into our brochure to get a comprehensive overview.
raw materials

Arc Intelligent Sensors Brochure

Download our brochure to learn how our Arc intelligent sensors can help you achieve greater process control, optimization, and increased productivity.
process analytics catalog

Process Analytics Catalog

Our Process Analytics Catalog provides detailed information on our sensors, accessories, software solutions, and their specifications, enabling you to select the best solution for your specific production process needs.
Conductivity sensor Brochure

Conductivity Sensors Brochure

Download our brochure to discover our range of conductivity sensors. Learn about the exceptional performance and suitability of the 4-pole platinum sensors for a wide range of Biopharma applications.

pH Measurement Guide

This guide will demystify pH measurement, covering topics ranging from the fundamentals of pH and its importance in various applications to the advanced techniques and best practices for accurate measurements.

Cell Density Applications eBook

Hamilton's Cell Density Applications eBook provides process engineers with valuable insights into the wide range of applications covered by our cell density sensors. Real process examples included.

CO2 - A Critical Process Parameter?

Discover the significance of measuring dissolved CO2 in a bioreactor through this white paper. Gain insights into the process and understand how continuous CO2 monitoring boosts yield and efficiency.

Optical DO Measurement White Paper

Hamilton's white paper on optical dissolved oxygen sensors reveals the key to maximizing efficiency by harnessing the power of these sensors, offering valuable insights and practical tips.
Field Services

Support at all times

We offer a variety of services and support to our clients. We provide field service, technical and application support, as well as a range of online resources. Our Field Service team enables on-site support of our product portfolio to ensure performance and reliability from installation support to preventative maintenance, including initial qualification & operation qualification, calibration services, diagnostics and tailored training programs.

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What our customers are saying

Versatility and ease of integration of Hamilton sensors.

In our QbD-centered PAT ecosystem, which requires frequent adaptation to different bioprocess modes and R&D setups, we especially value the versatility and ease of integration of the Dencytee Arc system.

Lukas Neutsch Lukas Neutsch, ZHAW - Zürcher Hochschule für Angewandte Wissenschaften

Hamilton’s 4UxF Arc Conductivity Sensors became an integral part of our processes.

Hamilton’s 4UxF Arc Conductivity Sensors has become an integral part of our processes, seamlessly performing in downstream applications. The sensors are ±3% to ±5% accurate, provide consistent and repeatable measurements over a wide range (1 µS/cm to 300 mS/cm) of conductivity values. The conductivity sensors have helped us to improve our product quality, reduce our production costs, and ensure the consistency of our products.

Marko Scharfe, Teva Pharma

I could not be more pleased with my experience with Hamilton!

My company has been using Hamilton probes for years and have always been happy with their performance! The team is always very helpful in trouble shooting issues and answering any questions that we may have about our probes. Overall, I could not be more pleased with my experience with Hamilton!

Abigail Mann, Heliae Development
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