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Upstream Pilot & Production
Sensor Solutions for Biopharma Upstream Process
The biopharma upstream process initiates the growth of microbes and cells, sourced from bacterial or mammalian cell lines. The cultivation and expansion of these entities are facilitated by the addition of nutrients, growth hormones, or specialized cell culture media into the bioreactor.
Hamilton's sensor solutions ensure real-time, reliable measurements of Critical Process Parameters (CPPs) and Key Performance Indicators (KPIs). From the intricacies of cell growth to the complexities of fermentation control, our sensors empower you to make data-driven decisions, ushering in a new era of efficiency and precision in upstream processes
Sensors and Accessories for Critical Process Parameters in Upstream
At Hamilton, we understand the importance of precise process control at each step of the upstream process to ensure optimal product quality and safety. That's why we specialize in in-line sensors and accessories that enable you to measure Critical Process Parameters (CPPs) like pH, Conductivity, Dissolved Oxygen, and Key Performance Indicators (KPIs) such as Total Cell Density and Viable Cell Density in real-time, eliminating the need for manual off-line sampling. Our sensors in combination with our housings are compatible with a wide range of systems, making them a versatile and flexible solution for any biopharmaceutical manufacturer.
Take a look at the Upstream Process below and discover what measuring solutions Hamilton has to offer:
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Solutions for the Bioreactor
Aerobic or anaerobic processes are run mainly in stainless steel bioreactors to produce small or large molecules. Process conditions are optimized during pilot-scale, before progressing towards production-scale. To ensure the high quality of the media, pH, Dissolved Oxygen, Viable Cell Density, Total Cell Density and CO2 control is very important. Here you will find an overview of all our sensing solutions for the bioreactor:
pH SensorsSensor Output Single-UseReusableTraditional (analog) EasyFerm Bio Traditional (Foodlyte Electrolyte)Digital (Memosens) n/aEasyFerm Bio Memosens (Foodlyte Electrolyte)Intelligent (Arc) EasyFerm Bio Arc (Foodlyte Electrolyte)Dissolved Oxygen SensorsSensor Output Single-UseReusableTraditional (Analog) n/a Digital (Memosens) n/a Intelligent (Arc) Viable Cell Density SensorsSensor Output Single-UseReusableIntelligent (Arc) Total Cell Density SensorsSensor Output ReusableIntelligent (Arc) Carbon Dioxide SensorsSensor Output ReusableIntelligent (Arc) CapsLiquid Solutions -
Solutions for Media Preparation Tank
Media for cell culture or fermentation are prepared in a sterile environment and monitored carefully in order to get reliable results in the upstream process. To ensure the high quality of these solutions, tight pH and conductivity control is very important. Here you will find an overview of all our sensing solutions for media preparation:
pH SensorsSensor Output Single-UseReusableTraditional (analog) EasyFerm Bio Traditional (Foodlyte Electrolyte)Polilyte Plus Traditional (Phermlyte Electrolyte) Digital (Memosens) n/aEasyFerm Bio Memosens (Foodlyte Electrolyte)Polilyte Plus Memosens (Phermlyte Electrolyte) Intelligent (Arc) EasyFerm Bio Arc (Foodlyte Electrolyte)Polilyte Plus Arc (Phermlyte Electrolyte) Conductivity SensorsSensor Output Single-UseReusableTraditional (Analog) n/a Intelligent (Arc) Liquid Solutions -
Solutions for the Harvest Tank
Once the cell culture or fermentation process is finished the content of several bioreactors are transferred and collected in the harvest tank. At this stage, maintaining the pH and Dissolved Oxygen concentration of the media is imperative. Here you will find an overview of all our sensing solutions for the harvest tank:
pH SensorsSensor Output Single-UseReusableTraditional (analog) EasyFerm Bio Traditional (Foodlyte Electrolyte)Digital (Memosens) n/aEasyFerm Bio Memosens (Foodlyte Electrolyte)Intelligent (Arc) EasyFerm Bio Arc (Foodlyte Electrolyte)Dissolved Oxygen SensorsSensor Output Single-UseReusableTraditional (Analog) n/a Intelligent (Arc) CapsLiquid Solutions -
Solutions for CIP Cleaning
The CIP (Clean In Place) process ensures that equipment is cleaned and maintained to minimize any possible cross-contamination and improve safety and product quality. To ensure the quality of this process, tight pH and conductivity control is very important. Here you will find an overview of all our sensing solutions for CIP cleaning:
pH SensorsSensor Output ReusableTraditional (Analog) Digital (Memosens) Intelligent (Arc) Conductivity SensorsSensor Output ReusableTraditional (Analog) Intelligent (Arc) Liquid Solutions
Benefits of using Hamilton Sensors
Complete Portfolio
Measure Critical Process Parameters (CPPs) and Key Performance Indicators (KPIs) which enable the holistic understanding and control of your process
Seamless Integration
Minimize the time and effort required to procure, validate, and effectively utilize a Hamilton sensor
Highest Quality / Ready for GMP compliance
Benefit from products with the highest manufacturing standards to meet or exceed all FDA and GMP regulatory requirements
Process Analytics Know-how
Hamilton provides 30+ years of experience of process sensors developed for biopharma applications
The Power of Arc Intelligent Sensors
Hamilton’s Arc intelligent sensors redefine the relationship between sensors and transmitters, opening a wide range of operational process improvements and cost reduction. Arc intelligent sensors provide advanced alarms, troubleshooting, quality indicators, and diagnostics simultaneously to the control system and to an optional mobile device. An integrated micro-transmitter eliminates a point of failure by directly connecting the sensor to the PCS.
How does PAT apply to the Bioreactor?
Download our comprehensive white paper and explore what PAT means in Biopharma Upstream processes. Discover cutting-edge solutions to effectively monitor critical process parameters and ensure product quality.
Download Related Brochures & our Product Catalog
Biopharma Brochure
Arc Intelligent Sensors Brochure
Process Analytics Catalog
Conductivity Sensors Brochure
pH Measurement Guide
Cell Density Applications eBook
CO2 - A Critical Process Parameter?
Optical DO Measurement White Paper
Support at all times
We offer a variety of services and support to our clients. We provide field service, technical and application support, as well as a range of online resources. Our Field Service team enables on-site support of our product portfolio to ensure performance and reliability from installation support to preventative maintenance, including initial qualification & operation qualification, calibration services, diagnostics and tailored training programs.
On-Demand
Pioneering Sensor Technology to Solve Biopharma Challenges
Process Analytics
In this webinar you will gain insights into the cutting edge of sensor technology and its impact on the biopharmaceutical industry. Learn about Hamilton's sensor solutions through case studies showcasing their impact on biopharmaceutical manufacturing.
- 1 hour
On-Demand
Sensors for GMP Environments: Compliance with GAMP 5 - Part 11 & Annex 11
Process Analytics
The goal of process analytical technologies (PAT) is to make production processes reliable through real-time process monitoring. This webinar will provide an overview about how Hamilton supports regulated companies' efforts with its GMP ready products.
- 40 minutes
Process Analytics Webinars
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