The Power of In-Line Cell Density Measurement
On-line, or in-situ, measurement is the pinnacle of process monitoring and necessary for true process control as evidenced with control of pH and dissolved oxygen, common for most biological processes. In fact, many parameters can be monitored but those directly related to cell physiology are typically time consuming off-line measurements that provide only a reactionary window into the past. Incyte Arc and Dencytee sensors provide a means for directly measuring viable cell density and total cell density in real-time, meeting the increasing need for PAT in the biopharmaceutical industry.
Will Hamilton Cell Density Sensors Work With My Process?
Hamilton cell density sensors are compatible with many types of cell lines and microbial strains, process types, and industries. Read more below or download our Cell Density Applications eBook to see real data with different cell lines and process types.
App Note - Online monitoring of CHO cell culture
App Note - Real-time cell density measurement for PAT applicationsAn application highlighting the use of Incyte and Dencytee in a PAT approach to monoclonal antibody (mAb) production.
App Note - Xylitol fermentationLearn how Hamilton pH, DO, and cell density sensor technology helps the Budapest University of Technology and Economics work with different yeast strains to optimize xylitol yield.
App Note - Real-Time VCD Monitoring of Moss for Therapeutic Protein ProductionIn-line Measurement of Viable Cell Density in a Photobioreactor
App Note - Real-time total cell density measurement of yeast fermentationsDencytee is used to optimize fermentation conditions for yeast processing.
Brochure - Incyte Arc
Will Incyte work with my cell line?
How does Incyte measure viable cell density?Incyte is a capacitance-based sensor responsive only to living cells.
What is the effect of agitation variations on the Incyte measurement?The agitation can influence the size of air bubbles. This number and size of air bubbles can affect the Cell Density measurement.
Can the electric field of Incyte damage/harm the cells?No. The frequency of the electric field applied by the system is within 300 kHz and 10 MHz. These frequencies do not damage the cells.
Cell Density Knowledge Base Articles
Incyte Cell Density Measurement PrinciplesIncyte enables the dual frequency measurement mode, or a frequency scanning. Learn about how Hamilton Incyte cell density sensors can continuously measure viable cells.
Dencytee Cell Density Measurement PrincipleLearn about how Hamilton Dencytee total cell density sensors can continuously measure viable cells.
Connecting Cell Density (Pre-amp Versions) to External SystemsThis article discusses the various options to output cell density measurement data to external devices such as PLCs and control systems.
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