Cell Density Sensors
The Power of In-Line Cell Density Measurement
On-line, or in-situ, measurement is the pinnacle of process monitoring and necessary for true process control as evidenced with control of pH and dissolved oxygen, common for most biological processes. In fact, many parameters can be monitored but those directly related to cell physiology are typically time consuming off-line measurements that provide only a reactionary window into the past. Incyte Arc and Dencytee sensors provide a means for directly measuring viable cell density and total cell density in real-time, meeting the increasing need for PAT in the biopharmaceutical industry.
Viable Cell Density Sensors
Total Cell Density Sensors
How Does Cell Density Measurement Work?
Many parameters like pH and dissolved oxygen can be monitored in-line but those directly related to cell physiology are typically time consuming offline measurements that require many manual steps. Total and Viable Cell Density measurement is now possible in-line with a new breed of sensors. Learn more about saving time and effort and increasing productivity and process understanding with in-line cell density sensors in the video below.
Will Hamilton Cell Density Sensors Work With My Process?
Hamilton cell density sensors are compatible with many types of cell lines and microbial strains, process types, and industries. Read more below or download our Cell Density Applications eBook to see real data with different cell lines and process types.
*Sampling required during initial modeling and model maintenance
App Note - Online monitoring of CHO cell culture
App Note - Human Platelet Protein Production from Human Cell Culture using an Advanced BioreactorOnline viable cell density monitoring in a platelet bioprocess production.
App Note - Correlation between Capacitance Signal and Viable Cell Density of Insect CellsWild type Sf-9 cell-line vs. polyclonal stable Sf-9 cell line
App Note - Continuous Cyanobacteria - Limnospora (Spirulina) Monitoring in the MELiSSA Loop using DencyteeDrift free long term biomass monitoring for better understanding of process dynamics
App Note - Real-time cell density measurement for PAT applicationsAn application highlighting the use of Incyte and Dencytee in a PAT approach to monoclonal antibody (mAb) production.
Catalog - Process AnalyticsDownload the Process Analytics sensor catalog to learn about the complete offering of Hamilton process sensors and accessories.
Brochure - BioPharmaInnovative solutions for process analytics in biotechnological and pharmaceutical industries.
Infographic - Online Cell DensityAn infographic highlighting the use and benefits of on-line cell density measurement.
Will Incyte work with my cell line?
How does Incyte measure viable cell density?Incyte is a capacitance-based sensor responsive only to living cells.
What is the effect of agitation variations on the Incyte measurement?The agitation can influence the size of air bubbles. This number and size of air bubbles can affect the Cell Density measurement.
Can the electric field of Incyte damage/harm the cells?No. The frequency of the electric field applied by the system is within 300 kHz and 10 MHz. These frequencies do not damage the cells.
Cell Density Knowledge Base Articles
Incyte Cell Density Measurement PrinciplesIncyte enables the dual frequency measurement mode, or a frequency scanning. Learn about how Hamilton Incyte cell density sensors can continuously measure viable cells.
Connecting Cell Density (Pre-amp Versions) to External SystemsThis article discusses the various options to output cell density measurement data to external devices such as PLCs and control systems.
Data Analysis Tools (Cell Density Pre-Amp versions)Hamilton provides several tools to interpret cell density data and correlate it with offline measurements. Download them here.
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