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Revolution of Total Cell Density Measurement

Total cell density measurement by the Dencytee sensor is based on optical density, commonly known as the turbidity of a suspension at near-infrared (NIR) wavelengths. All particles and molecules that scatter the NIR light will be detected. This optical density signal can be correlated to the total cell density measured by different offline measurement techniques. Find out more about Hamilton’s Dencytee and Dencytee Arc sensors and their unique measurement modes.

Dencytee Arc

Dencytee Arc sensors enable real-time, in-situ measurement of total cell density using transmittance and reflectance of near-infrared light in low and high cell density applications. Guided in-line/off-line correlation modeling, using the ArcAir software, facilitates the creation of a total biomass sensor. Reduce off-line sampling and increase the reliable optical density measurement range.

Dencytee In Action

From increasing yield to shortening process time, the real power of optical density is in your hands. As shown in the examples below, ask yourself what you could do with continuous process data.

Never Miss an Important Process Event

High resolution, continuous measurement technology enables real-time measurement of the bioprocess, improving process understanding.

Automated Control

Real-time total biomass measurement in-process enables automation and control strategies. Reduce manual intervention by automating process steps such as induction, feeding, or harvest timing.

Correlate to Offline Biomass Measurements

With Dencytee Arc, a built-in correlation model provides a robust link between the in-line optical density signal and commonly used off-line measurements of biomass. Enables real-time, in-situ data of off-line biomass concentrations.

Strengthen the Reliability of the TCD Measurement Results

Monitor every event in your process to enable efficient process control. Simplify and automate process steps like induction, feeding, or harvesting.

Increase Efficiency

Reduce long off-line analysis in the laboratory. Reduce human error introduced by excessive sample handling. Increase efficiency and measurement quality.

Easy Transmitterless Integration

Hamilton Arc technology enables seamless integration to a control system, PLC, or DCS without a bulky transmitter. Leverage the Arc platform to perform maintenance and configuration with ArcAir™ software.

Available Tools

Will Hamilton Cell Density Sensors Work with My Process?

Review Hamilton's Cell Density Applications Ebook

Hamilton cell density sensors are compatible with many types of cell lines and microbial strains, process types, and industries. Read more below or download our Cell Density Applications eBook to see real data with different cell lines and process types.


Start a Conversation

After starting a conversation with a Hamilton's team member, you will have access to an applications specialist to discuss the potential of Hamilton Incyte Arc sensors in your bioprocess

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Utilize Hamilton’s Application Team and proven evaluation process for rapid implementation and robust product evaluation.


Hamilton's knowledge base provides a range of explanatory articles, frequently asked questions, and document downloads.

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