Dencytee PreAmp
Total cell density measurement by the Dencytee sensor is based on the optical density, the turbidity of a suspension at NIR wavelengths. All particles and molecules that scatter the NIR light will be detected and can be correlated to the total cell density measured offline. The Dencytee sensor increases the light intensity as turbidity rises leading to a wide measuring range.
How does Dencytee work?
Dencytee measures the turbididty at NIR (near infra-red) wavelengths so it is insensitive to changes in media color. All particles that scatter light at 880 nm will be detected, including living and dead cells.
Accessories for Dencytee Sensors
A measuring loops consist of an Dencytee sensor and a pre-amplifier, which are factory calibrated. The Sensor Unit is connected to a Cell Density Controller and provides a variety of communication protocols, from analog 4-20 mA signal to digital OPC-XML-DA connection. Diverse accessories are available to complete the portfolio.
Cell Density Controllers and Accessories
Cell Density Cables
Dencytee Sensor Maintenance
Specific Applications
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App Note - Continuous Cyanobacteria - Limnospora (Spirulina) Monitoring in the MELiSSA Loop using Dencytee
Drift free long term biomass monitoring for better understanding of process dynamics -
App Note - Real-time cell density measurement for PAT applications
An application highlighting the use of Incyte and Dencytee in a PAT approach to monoclonal antibody (mAb) production. -
App Note - Online monitoring of CHO cell culture
A suite of Hamilton sensors is used to continuously monitor batch fermentation of CHO cells for tighter process control. -
App Note - Real-time total cell density measurement of yeast fermentations
Dencytee is used to optimize fermentation conditions for yeast processing.
Resources
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Brochure - BioPharma
Innovative solutions for process analytics in biotechnological and pharmaceutical industries. -
Infographic - Online Cell Density
An infographic highlighting the use and benefits of on-line cell density measurement. -
Quick Guide - Dencytee Sensors
Quick Guide for Dencytee Sensors
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Where can I find documentation and certificates for my sensors?
Paper copies sensor information such as manuals, declarations of quality, and material certificates ship with the product. Hamilton also has several website resources to find related information. Click on the FAQ to learn more. -
How much torque is needed to install a sensor with PG13.5 threads?
Sensors with PG13.5 threads rely on the o-ring to seal against process pressure. Finger-tight (approximately 2 Newton Meter or 18 inch-lb) should be sufficient to install the sensor without leakage. Additional tightening beyond this can deform the o-ring or strip the threads.
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Dencytee (Pre-Amp) Total Cell Density Measurement Principle
Learn about how Hamilton Dencytee total cell density sensors can continuously measure viable cells. -
Connecting Cell Density (Pre-amp Versions) to External Systems
This article discusses the various options to output cell density measurement data to external devices such as PLCs and control systems. -
Sensor Initialization: ArcView Cell Density Controller and ComBox (Pre-Amp Products)
ArcView Controller and Combox products used with Incyte and Dencytee (pre-amp versions) require sensor initialization. This article tackles common questions associated with this procedure.
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