Cell Density Knowledge Base Articles

Dencytee Arc Quick Checklist

The quick guide provides a walkthrough of the basic functions of your Dencytee Arc sensor.

Dencytee Arc Measurement Units

Dencytee Arc monitors in-line optical density (OD) in a wide range of processes. The total biomass sensor detects both live and dead cells, along with any debris or particulates which block light.

Dencytee Arc Total Cell Density Measurement Principle

Optical density (OD, sometimes called turbidity) is commonly used to estimate the total biomass or concentration of cells within a suspension. Cell concentrations are important to monitor in fermentation processes to detect and correct for process deviations.

Cell Density Measurement Guidelines

Process Analytical Technology (PAT) is crucial in any biopharma application. One Key Process Indicator critical to PAT implementation is how many cells are present (also known as cell density).

Wiring for Dencytee Arc Total Cell Density Sensors

Dencytee Arc total biomass sensors come standard with Modbus RTU (RS485) digital protocol. This article helps you wire a total cell density sensor.

Dencytee Arc Verification and Service Calibration

Hamilton’s intelligent in-line sensors are designed to record and transmit diagnostic data, including verification information. The verification ensures that a sensor is functioning properly.

Offline Correlations for Dencytee Arc

To use Dencytee Arc as an in-line total cell density probe, a relationship between the raw measurement signal (optical density) and the offline total cell density measurement must be established. This article will guide you through the process.

Dencytee Arc Installation

Dencytee Arc installation instructions in a bioreactor. For first time sensor use, check functionality prior to insertion into the bioreactor.

Incyte Arc PCS Connections for Existing Cell Density Users

This article reviews changes in the sensors connection strategy between the older pre-amp version of Incyte Cell Density products and the newer Incyte Arc products.

Wiring for Incyte Arc Cell Density Sensors

There are several wiring options for Incyte Arc sensors depending on the intended goals of the installation. This Knowledge Base article provides a quick guide to wiring this product for each scenario.

Data Logging Options for Incyte Arc Cell Density Sensors

There are two options to capture data with Incyte Arc Cell Density Sensors. This article provides step-by-step instructions on each.

Predicting Actionable Timeframes in Cell Culture Using Inline Cell Density Measurement

The following case study describes how inline permittivity was utilized in a viral expression animal culture to estimate VCD in-situ and identify optimal time for viral infection using a continuous predictive model.

Incyte Cell Density Measurement Principles

Incyte enables the dual frequency measurement mode, or a frequency scanning. Learn about how Hamilton Incyte cell density sensors can continuously measure viable cells.

Dencytee (Pre-Amp) Total Cell Density Measurement Principle

Learn about how Hamilton Dencytee total cell density sensors can continuously measure viable cells.

Connecting Cell Density (Pre-amp Versions) to External Systems

This article discusses the various options to output cell density measurement data to external devices such as PLCs and control systems.

Data Analysis Tools (Cell Density Pre-Amp versions)

Hamilton provides several tools to interpret cell density data and correlate it with offline measurements. Download them here.

Incyte Sensors (Pre-amp Version) - Standard vs. Low Conductivity

There are several different options for Incyte cell density sensors based on liquid conductivity. Learn more about sensor selection / applications.

Maintaining ArcView Controller Data Storage

Recording cell density data over time can eventually fill up the hard drive of the ArcView controller. This article details the methodology to purge the controller for optimal operation.

Sensor Initialization: ArcView Cell Density Controller and ComBox (Pre-Amp Products)

ArcView Controller and Combox products used with Incyte and Dencytee (pre-amp versions) require sensor initialization. This article tackles common questions associated with this procedure.

ArcAir Data Modeling Software

VCD Soft Sensor: Close the gap between your off-line viable cell density data points.