Dissolved Carbon Dioxide (CO₂) Sensors
Dissolved CO₂ sensor for real-time bioprocess control
Strengthen reliability across your biopharma production processes.
Integrate Hamilton’s CO₂NTROL dissolved CO₂ sensor for real-time, automated monitoring that supports your bioprocessing process control efforts. Built for biopharma production processes, the solid-state, maintenance-free DCO₂ design ensures consistently accurate dissolved carbon dioxide measurement while minimizing downtime. Through real-time monitoring of a critical process parameter (CPP), CO2NTROL can help to improve product yields and quality. Additionally, rely on expert Hamilton support and resources to help you achieve bioproduction reliability and scalability at every stage.
Benefits
Bioreactor Size Impacts Dissolved Carbon Dioxide
Large and small bioreactors have Mass Transfer Coefficients (KLa) that change the dissolution and stripping characteristics from reactor to reactor. As a result, the same process control strategy will result in different carbon dioxide accumulation across R&D, Process Development, and Production scale reactors. Only real-time monitoring and control of dissolved CO₂ to an optimized profile will result in comparable mass transfer independent of scale.
Optimizing Yield | Scale Up | Scale Down |
Excessive Accumulation During a process excess CO₂ accumulation is common as cell concentration increases and more metabolic CO₂ is produced. This accumulation reduces intracellular pH resulting in slower enzymatic activity or delayed lactate shift. The outcome is lower production quantity and quality. | Excessive Removal Aggressive aeration and mixing can prevent detrimental accumulation of CO₂. However, too little CO₂ can slow cell growth, metabolism, and productivity by starving cells of CO₂ needed for the formation of metabolic intermediates. Excessive removal can also reduce buffer capacity in bicarbonate systems. | Uncontrolled CO₂ Range Media addition and process adjustments can result in large swings in dissolved CO₂ that may go unnoticed with infrequent offline monitoring and adjustment. Continuous inline control at the optimal level yields increased viable cell density, production phase duration, and titer. |
Dissolved Carbon Dioxide Sensors Resources
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Services
Hamilton's Technical Support team is here to provide product trouble-shooting, repair, application support, virtual start-up support, and more.
Installation, set-up, and calibration support directly on-site. Our field service team ensures your sensors and cables are installed and functioning correctly.
Support for the qualification of Hamilton equipment including complete documentation. Readying your process for GMP manufacturing activities.
Preventative maintenance and regular service contracts. Schedule on-site service dates to ensure your sensors are properly maintained and your process is optimized.
Diagnosing and resolution of process system problems on-site. Finding the root cause and presenting a solution to fit your needs.
User trainings and on-site trainings for technicians. Tailored training ranging from basic operation to advanced calibration and maintenance.
Backed by world-class service and support.
For over 75 years, the Hamilton name has been recognized globally for its unwavering commitment to quality. That pledge extends to creating long-term customer partnerships. We're proud to offer in-depth training courses, on-site field support, custom product builds, and so much more.
Let's Talk
Connect with a Hamilton expert to discuss solutions for your workflow. We are here to enable your success.
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