White Paper: Dissolved CO₂ (pCO₂) at the Bioreactor

dissolved carbon dioxide sensor

Learn how Implementing Real-Time Control of Carbon Dioxide can Impact Productivity at R&D and Production Scale Bioreactors

Dissolved CO₂ is a Critical Process Parameter (CPP) in biopharma production processes, as it has a direct impact on product titer and its critical quality attributes. It influences other culture parameters like extracellular and intracellular pH, as well as key performance indicators such as Viable Cell Density. Uncontrolled dissolved carbon dioxide levels in the bioreactor can result in growth inhibition, lower product titer, and decreased product quality.

Download our White Paper to learn about:

  • The fundamentals of DCO2 in bioprocesses
  • Why DCO2 is a Critical Process Parameter
  • Why monitoring and controlling DCO2 in real time is important


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Automated DCO₂ Control Benefits:

increased titer

Increased Product Titer

Real-time DCO2 monitoring and control leads to higher product concentrations, maximizing productivity in bioprocesses.
reproducibility

Better Batch-to-Batch Reproducibility

Controlling DCO2 levels in real-time minimizes variations between batches, ensuring consistent and reliable bioprocess outcomes.
consistency

Improved consistency across R&D and Production Scale Seactors

Real-time DCO2 monitoring and control enables consistent process performance across different scales, optimizing manufacturing efficiency.

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dissolved oxygen whitepaper