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Dose-Response Assays with Nanoliter Precision

Explore how BIOSPOT® Workstation enables the generation of 11-point half-log dose-response curves with minimal DMSO usage and automated pipe cleaning. This application note demonstrates accurate Celecoxib titration using non-contact nanoliter dispensing for COX-2 inhibition assays.

Hamilton BIOSPOT application note cover: "Next-Level Dose-Response Assays with BIOSPOT®" title on dark blue background with partial instrument image
Parallel Cell Toxicity Screening with 8 Compounds

This application note shows how BIOSPOT®Workstation automates nanoliter-scale dosing for eight compounds in parallel on HEK293 cells. Learn how to achieve reproducible EC50 curves while maintaining 0.5% DMSO and minimizing manual handling through full automation.

Hamilton BIOSPOT® Workstation application note cover showing cultured cells under microscopy and the BIOSPOT instrument.
Microneedle Coating with Nanoliter Precision

Discover how the BIOSPOT® DX enables non-contact, high-precision droplet coating on microneedles using PIPEJET® technology. This fully automated process ensures accurate volume, reliable deposition, and minimal material loss, deal for drug delivery innovation.

Hamilton application note cover: "Non-contact microneedle coating utilizing drop-on-demand PIPEJET® technology"
Nanoliter Spotting for MALDI-MS Imaging

Learn how BIOSPOT® DX enables precise and reproducible deposition of calibration standards onto tissue slices for quantitative MALDI-MS imaging. This application note demonstrates how SMARTDROP® and TOPVIEW work together to deliver low-volume spotting with sub-nanoliter accuracy, ideal for drug distribution studies and biomarker quantification.

Hamilton application note cover: "Deposition of reference standards on tissues for quantitative MALDI mass spectrometry imaging"
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