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Deposition of reference standards on tissues for quantitative MALDI mass spectrometry imaging

BIOSPOT DX nanoliter liquid handling workstation beside a camera control software interface showing colored spots on tissue

Automated Calibration Spotting for Quantitative MALDI Mass Spectrometry Imaging

In pharmaceutical research and tissue-based drug analysis, quantitative MALDI mass spectrometry imaging (qMSI) plays a critical role in understanding biomolecule and drug distribution. A key challenge in qMSI is generating accurate, spatially resolved calibration curves using standard reference solutions.

This Application Note showcases how the BIOSPOT® DX nanoliter dispensing platform enables precise, automated deposition of calibration standards directly onto tissue sections—ensuring high-resolution quantitation within the native sample matrix.

Performance that Advances qMSI Workflows

  • Precise: Delivers 20 nL droplets with sub-droplet calibration for tight spot-to-spot consistency
  • Reproducible: Camera-guided spot placement and automated patterning minimize spatial variance
  • Efficient: Enables dense, low-volume calibration mapping with minimal sample and matrix use

Download the Application Note to read on.