Next-Level Dose-Response Assays with BIOSPOT: Precision and Efficiency in Compound Curves

App Note Dose Response Assay BIOSPOT TIMG

Automated Dose-Response Assays with BIOSPOT®

Throughout lead identification and lead optimization phases of drug development, initial hit compounds are tested in dose-response assays (EC50, IC50, ADME Tox assays). Those assays are fundamental experiments in pharmacology and toxicology, aimed at understanding the relationship between the dose of a substance and the extent of the response it provokes in a biological system (i.e. efficacy and toxicity). Dose-response curves allow for the comparison between different substances and thus their clinical and therapeutic values. The automated setup of concentration curves with the BIOSPOT® workstation allows for precise nanoliter dispensing without the use of multiple tips.

Key Benefits at a Glance

  • Precise: Achieving lowest possible compound concentrations while keeping the DMSO level to a minimum.
  • Flexible: Up to 6 plates freely addressable on deck with no need for plate handling or inverting.
  • Sustainable: Automated pipe cleaning eliminates the need to manually replace pipes and allows their reuse.

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