PRP-Z2

prp-z2 column

PRP-Z2 was specifically engineered to maximize polar retention through a combination of deeper pores, higher surface area, and embedded polar moieties. These features improve retention and selectivity for highly polar and cationic analytes. PRP-Z2 particles have a (160 Å) pore size that is suitable for the separation of some large molecules such as small proteins, peptides, oligonucleotides, as well some small polar compounds.

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PRP-Z2 Overview

Excellent retention for polar compounds

The PRP Z2 represents a sophisticated evolution of the renowned PRP resin family. Engineered with a highly cross-linked PS-DVB backbone, it offers exceptional structural rigidity and maintains peak performance across the entire pH spectrum—from strongly acidic to highly alkaline mobile phases. This robust stability ensures reliable isolation for a vast array of analytes using any standard chromatographic eluent.

By integrating both aromatic rings and aliphatic cross-linking into the particle architecture, the PRP Z2 achieves superior analyte retention compared to traditional commercial polymeric resins. This increased cross-link density not only enhances lipophilic retention but also creates a more rigid spherical structure that minimizes swelling and accelerates eluent response times.

Specifically designed to maximize polar interactions, the PRP Z2 features deeper pores, a higher surface area, and embedded polar moieties. These advancements significantly improve selectivity and retention for highly polar and cationic species. Enhanced performance has been demonstrated across several key compound classes, including organic acids, proteins, oligonucleotides, peptides, and various other biological molecules.  For additional information, please refer to the PRP-Z2 Product Datasheet

PRP-Z2 Columns

That PRP‑Z2 material was specifically engineered to maximize polar retention through a combination of deeper pores, higher surface area, and embedded polar moieties, thereby improving retention and selectivity for highly polar and cationic analytes. Its particles, with a 160 Å pore size, are suitable for the separation of certain larger molecules such as small proteins, peptides, and oligonucleotides, as well as small polar compounds.
PRP Z2 Column

PRP-Z2 Guard Columns

Guard columns can provide many benefits when used upstream from an analytical, preparative, or semi-preparative column. Guard columns are typically chosen to have the same packing as the primary column.
HPLC Stainless Steel Analytical Guard Column

PRP-Z2 Bulk Resin

Hamilton chromatography resins can be ordered in bulk, i.e., not packed into column hardware. This is a low-cost approach to application-specific testing and analyses.
Bulk resin

PRP-Z2 Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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Application Note

Advanced Chromatographic Separation of Diquat and Paraquat: Longer Retention Times and Enhanced Selectivity

Hamilton's PRP-Z2 solves analytical challenges of EPA-regulated diquat and paraquat separation through enhanced design, enabling fast, robust analysis with improved throughput and reduced solvent use.
Oligo App Note for Z2 Single Helix

Application Note

Achieving High‑Resolution Separation of Oligonucleotides with Novel PRP‑Z2 HPLC Columns

This application note demonstrates PRP-Z2's pH-independent, thermally stable oligonucleotide separations with reduced ion-pairing reagents and high efficiency.
Printed data sheet titled "Hamilton PRP-Z2 HPLC Column Data Sheet" featuring a photo of an HPLC column and a benefits callout box.

Datasheet

PRP-Z2 Data Sheet

This data sheet shows how the PRP-Z2 was specifically engineered to maximize polar retention through a combination of deeper pores, higher surface area, and embedded polar moieties.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Tractor Spraying Pesticides on Crops

Application Note

Advanced Chromatographic Separation of Diquat and Paraquat: Longer Retention Times and Enhanced Selectivity

Hamilton's PRP-Z2 solves analytical challenges of EPA-regulated diquat and paraquat separation through enhanced design, enabling fast, robust analysis with improved throughput and reduced solvent use.
Oligo App Note for Z2 Single Helix

Application Note

Achieving High‑Resolution Separation of Oligonucleotides with Novel PRP‑Z2 HPLC Columns

This application note demonstrates PRP-Z2's pH-independent, thermally stable oligonucleotide separations with reduced ion-pairing reagents and high efficiency.
Printed data sheet titled "Hamilton PRP-Z2 HPLC Column Data Sheet" featuring a photo of an HPLC column and a benefits callout box.

Datasheet

PRP-Z2 Data Sheet

This data sheet shows how the PRP-Z2 was specifically engineered to maximize polar retention through a combination of deeper pores, higher surface area, and embedded polar moieties.
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