nanoliter dispenser for GxP ALLDROP
Ultra-Precise
<3% CV
Consistent & Reliable Dosing
No Manual Calibration
Real-Time Drop Monitoring
Full traceability
Built for Automation
Plug & Play Integration
Compact. Modular. OEM-Ready

Precision Meets Traceability—Effortlessly

Ensure precise, traceable, and GxP-compliant liquid dispensing with the ALLDROP®,  designed for high-precision manufacturing processes, research, and easy system integration.

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Use case

How It's Used

 Precise microdispensing for regulated industries

Discover how the ALLDROP® nanoliter dispenser enhances pharmaceutical vial filling and clinical trial processes by delivering ultra-precise volumes, improving yield with real-time optical verification. ALLDROP ensures full traceability, reduces reagent waste, and streamlines compliance in GMP-regulated production environments.

ALLDROP Printhead

Precision Dispensing for Critical Workflows


ALLDROP is a precision dispenser engineered for nanoliter-scale accuracy in GMP, biotech, and diagnostic settings. Designed for automation engineers, production managers, and quality control teams, it ensures reliable performance, boosts throughput, and brings enhanced confidence to demanding liquid handling workflows.

Real-Time Monitoring and Full Traceability


Delivering consistent 20–70 nL droplets with <3% CV, ALLDROP uses in-flight optical imaging to monitor each droplet in real time. The system automatically logs volume, timestamp, operator ID, and droplet image to support full traceability and compliance with GMP and ISO 23783 standards.

Seamless Integration and Total Control


Automation-ready by design, ALLDROP includes a dedicated, user-friendly interface that provides full visibility and control over all dispensing parameters. Its language-agnostic gRPC protocol enables fast integration into any scheduler, making it ideal for building custom workflows or scaling up production lines with confidence.

Featured Technologies

Delivers nanoliter volumes with high accuracy, ensuring minimal waste and cross-contamination.

Each droplet is imaged and analyzed in real-time, providing full traceability and facilitating compliance with regulatory standards.

ALLDROP® includes a user interface with gRPC-based communication, enabling easy control and quick handover to any scheduler or automation platform.
 

Built-in ISO 23783 support and automated data logging streamline preparation for audits and reduce time spent on documentation.

Automatic priming and stable pressure control reduce reagent loss to under 0.5 µL, saving materials and supporting lean manufacturing.

  • Stainless steel ALLDROP printhead housing for cleanroom-ready, hygienic liquid dispensing.
  • ALLDROP magnetic reservoir connection enables fast, tool-free liquid changes.
  • ALLDROP magnetic dosing pipe holder for quick, contamination-free liquid swaps
  • Magnetic coupling system for easy printhead disconnection and maintenance.
  • Fast data cable connectivity for reliable printhead integration in automation.
  • CONTROLBOX hub with gRPC protocol for automated dispenser control

Robust, Automation-Ready Printhead Hardware

ALLDROP’s external and system-level hardware is built for industrial performance and integration. With a stainless steel printhead casing, magnetic quick-swap components, and seamless connectivity to its CONTROLBOX, ALLDROP® combines ruggedness and precision. Tool-free maintenance, cleanroom compatibility, and secure gRPC-based communication ensure that the system meets the needs of automation engineers, QC professionals, and production teams. Designed for speed, reliability, and traceability, ALLDROP® simplifies implementation in regulated workflows.

1

Stainless Steel Housing

The cleanroom-ready stainless steel housing simplifies maintenance and supports hygienic workflows. The printhead is easy to remove for cleaning or changeovers.
2

Fast Reservoir Exchange

The reservoir connects magnetically and independently from the actuation mechanism, allowing fast, tool-free swaps and preventing cross-contamination.
3

New Dosing Pipe Holder

The Quick-swap magnetic system allows fast, tool-free changes between liquids. The actuator is separated from fluid pathways, preventing cross-contamination.
4

Magnetic Coupling System

The magnetic coupling enables quick, tool-free disconnection of the printhead from the CONTROLBOX, ideal for fast maintenance, liquid changes, or accessing hard-to-reach printheads within enclosed or integrated automation setups.
5

Simple Connectivity

The ALLDROP printhead quickly and easily integrates via a dedicated data/power cable, ensuring fast, reliable signal transmission for automated workflows.
6

CONTROLBOX Automation Hub

The CONTROLBOX operates the printhead and supports gRPC-based communication, accepting commands from various scheduling sources.

Intelligent Dispensing with Real-Time Control

Inside the ALLDROP system, advanced components work together to deliver ultra-precise, contact-free nanoliter dispensing. The PIPEJET® actuator ensures droplet consistency with low dead volume, while the SMARTDROP optical monitoring system analyzes and logs every droplet in-flight. SMARTRESERVOIR provides stable pressure regulation across a variety of liquids. Together, these internal technologies power ALLDROP’s high-performance, traceable dispensing—ideal for GMP, biotech, and diagnostic applications where accuracy and data integrity are critical.

Technical drawing and location of the ALLDROP PIPEJET system.

1-Drop-on-demand Dispensing

Utilizes PIPEJET technology to ensure precise, contact-free liquid dispensing, reducing contamination, enhancing sample integrity, and increasing workflow efficiency.

Technical drawing and location of the ALLDROP SMARTDROP system.

2-SMARTDROP Optical Monitoring

Each droplet is analyzed and logged in real time, enabling automated printing and calibration and providing comprehensive documentation for regulatory audits and Good Manufacturing Practices (GMP) compliance.

Technical drawing and location of the ALLDROP SMARTRESERVOIR system.

3-Stable Pressure Control System

SMARTRESERVOIR maintains consistent dispensing performance by regulating pressure, minimizing fluctuations, and ensuring high-precision dosing.

ALLDROP® Specifications

ALLDROP Specifications

System Dimensions

Height
26 cm (10.24 in)
Width
7.1 cm (2.8 in)
Length
11 cm (4.33 in)
ALLDROP printhead non-contact dispensing system with PIPEJET technology for precise nanoliter liquid handling

General Specifications

Weight
4 kg

Volume Range 1

Auto Calibration
25-70 nL

Dispensing Performance

Viscosity Range 2
0.5-150 mPa.s
Dispensing Frequency 3
20 Hz

Process Control

SMARTDROP
Included

Control & Software Environment

Computer
Integrated

1 Liquid dependent

2 At room temperature

3 Performance values based on low-viscosity fluids; results may vary with different liquid properties.

ALLDROP® Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Services

Installation, set-up, and calibration support directly on-site. Our field service team ensures your sensors and cables are installed and functioning correctly.

Preventative maintenance and regular service contracts. Schedule on-site service dates to ensure your sensors are properly maintained and your process is optimized.

Hamilton's Dispensing Service offers feasibility testing to evaluate if your liquid and workflow are compatible with our dispensing technology.

Backed by world-class service and support.

For over 75 years, the Hamilton name has been recognized globally for its unwavering commitment to quality. That pledge extends to creating long-term customer partnerships. We're proud to offer in-depth training courses, on-site field support, custom product builds, and so much more.

Let's Talk

Connect with a Hamilton expert to discuss solutions for your workflow. We are here to enable your success.

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