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drug discover

RNA interference (RNAi) uses single stranded RNA molecules to silence the expression of specific genes by cellular mechanisms.

It is a potent approach for identifying genes involved in a particular genetic pathway or cellular process by individually silencing all genes in the genome model systems, usually in a cellular assay. Quantitative changes of a reporter are monitored by specific readouts. This technology is successfully used in drug discovery to identify new potential drug targets.

RNAi is typically used in genome-wide, high-throughput assays that require automation. In order to achieve quantitative data of high quality, the automated pipetting performance is crucial. Due to our Air Displacement technology, Hamilton liquid handlers can deliver even small microliter volumes required for those assays with high performance.