Real-time, in-situ glucose monitoring for bioprocessing R&D

The Hamilton GlucoSense Optical Sensor is a solution for mammalian cell culture bioreactors, offering accurate, real-time, and easy-to-use in-situ glucose monitoring to optimize cell culture productivity and accelerate development.

Receive More Information

GlucoSense Sensor Details

The Hamilton GlucoSense Sensor revolutionizes glucose monitoring in biopharma R&D by providing accurate, real-time, and in-situ measurements directly within your bioreactor. Traditional methods often fall short, requiring frequent manual intervention, complex calibrations, or specialized expertise that slows down process development. GlucoSense overcomes these limitations with its pioneering optical technology, delivering immediate and reliable data from day one, without the need for extensive MVDA calibration or cumbersome fiber-optic systems.

This robust sensor is fiber-optic free and proven compatible with numerous autoclavation and CIP cycles, ensuring durability and consistent performance. Its small-footprint design and PG 13.5 compatibility allow for seamless integration into existing bioreactor setups, eliminating the need for bulky external spectrometers. With a built-in Arc micro-transmitter supporting Modbus RS485 communication, GlucoSense simplifies data integration, enabling you to optimize mammalian cell culture conditions and accelerate your bioprocess development with confidence.

Common applications Pharma & Biopharma, Bioprocess Upstream

Optimize mammalian cell cultures with precise, real-time glucose monitoring.

Monitor mammalian cell cultures from day one, saving time on complex calibrations.

Robust, fiber-optic free design with seamless PG 13.5 integration.

Easy, Accurate Real-Time Monitoring

The GlucoSense sensor provides precise, real-time glucose measurements using straightforward in-situ process calibration. Start monitoring your mammalian cell cultures from day one. No complex model development or external calibration required. Safe to operate, the sensor eliminates the need for laser protection.

  • Designed for real-time, in-line monitoring.
  • The OneProcess membrane filters out cells, preventing interference and ensuring reliable accuracy.
  • The membrane maintains equilibrium by allowing only small molecules like glucose to reach the sensing element.

Robust and GMP Ready

Hamilton engineered the GlucoSense for long-term stability in demanding bioprocessing environments. Its robust, fiber-optic–free construction ensures durability and compatibility with multiple cleaning and sterilization protocols. The sensor comes fully supported with GMP documentation, helping you achieve compliance with confidence.

  • Proven compatibility with autoclavation.
  • GMP ready with comprehensive validation support.
  • IQ/OQ documentation and Standard Operating Procedure (SOP) for Computer System Validation (CSV) available.

Ease of Integration

The GlucoSense simplifies implementation with its compact, small-footprint design. The built-in Arc micro-transmitter provides digital intelligence and removes the need for bulky external spectrometers. Integration with your existing systems is seamless, as it connects directly to your control infrastructure using standard digital communication.

  • VP8 connector and compatibility with Modbus RTU
  • Fully integrates with all Hamilton Arc peripherals and ArcAir software
  • Easily installed using the standard PG 13.5 process connection.
  • Our experience with GlucoSense has been excellent

    Our experience with GlucoSense has been excellent. The probes were truly ready to use after mounting the membrane; only a simple product calibration was needed. Integration with ArcAir made them easy to handle, and the real-time glucose predictions supported our feed-back loops throughout the run. GlucoSense provided stable, real-time glucose measurements and predictions for over three weeks.

    Dr. Sherin Panikulam
    Scientific Associate, Bioprocess Technology Group – Institute for Pharma Technology and Biotechnology – FHNW Muttenz

GlucoSense Sensor Specifications

Print
Process Connection PG13,5
Wetted Parts Titanium 3.7035 coated with diamond like carbon
Diamond
EPDM (Ethylene propylene elastomer)
See compliance details in 2.1 Material Specification document REF 111011993
Electrical Connector VP8
Sensor Output Arc: Modbus
Measuring Range 0.5 to 25.0 g/L
pH Value The specified glucose measurement accuracy applies when the process pH remains constant within ±0.2 units
Electrolyte None
Accuracy at 25 °C ±0.5 g/l after product calibration at the measurement temperature. Valid for whole measurement range.
Sensor Insertion Depth Minimum 20 mm above the sensing element
Temperature Sensor NTC 47 kOhm
Configurable Values Glucose concentration: g/l, mg/dl, mg/l, mmol/l; Temperature: K, °C, °F
O-ring Material EPDM (Ethylene propylene elastomer)
Digital Interface RS485 Modbus (max. 32 addresses)
Operating Voltage 10 to 27 VDC
Certificate Yes, factory calibration with certified solutions
Diameter 12 mm
Autoclavable Yes (130 °C, 30-minute sterilization duration)
Operating Temperature Range -10 to 130 °C; the sensor provides no Glucose reading above 60 °C
Pressure Range bar g 0 to 5 bar(g)
Protection Rating IP68
Required Flow None
Temperature Measuring Range The declared glucose measurement accuracy is valid within the temperature range from 25°C to 38°C.
Software ArcAir 3.11 or successive releases
Surface Quality of Titanium Titanium coated with diamond like carbon with Ra < 0.4 μm (N5)

Compatibility with Hamilton Devices

Seamless integration with Hamilton's Arc system and bioprocessing solutions.

GlucoSense Sensor Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Services

Installation, set-up, and calibration support directly on-site. Our field service team ensures your sensors and cables are installed and functioning correctly.

Support for the qualification of Hamilton equipment including complete documentation. Readying your process for GMP manufacturing activities.

Preventative maintenance and regular service contracts. Schedule on-site service dates to ensure your sensors are properly maintained and your process is optimized.

Diagnosing and resolution of process system problems on-site. Finding the root cause and presenting a solution to fit your needs.

User trainings and on-site trainings for technicians. Tailored training ranging from basic operation to advanced calibration and maintenance.

Hamilton offers modular service contracts tailored to your requirements, featuring a basic module complemented by optional add-ons.

Backed by world-class service and support.

For over 75 years, the Hamilton name has been recognized globally for its unwavering commitment to quality. That pledge extends to creating long-term customer partnerships. We're proud to offer in-depth training courses, on-site field support, custom product builds, and so much more.

Let's Talk

Connect with a Hamilton expert to discuss solutions for your workflow. We are here to enable your success.

Request Type: