Ultra-Low Volume (ULV) dispensing

High-precision liquid dispensing solutions for labs.

Nanoliter precise dispensing for coumpound testing BIOSPOT
nanoliter dispenser for GxP ALLDROP
close up on 8 PIPEJET modules arranged in 9mm spacing into BIOSPOT workstation

Precision dispensing solutions tailored to your needs

Hamilton’s ultra-low volume dispensing technologies support assay miniaturization and precise liquid deposition onto microplates, microfluidic devices, and diagnostic chips. From benchtop systems to OEM components, our automation-ready platforms deliver consistent performance with low dead volume, vision-guided control, and expert integration support to scale your workflows with precision and speed.

What you can expect

  • High-Precision Dispensing

    Deliver consistent, ultra-low volume drops with excellent accuracy (≤ 3% CV), ideal for assay miniaturization, diagnostics, and advanced research.

  • Substrate & Workflow Flexibility

    Dispense directly onto your microt plates, chips, slides, or custom formats using adaptable hardware and automation-ready software.

  • Scalable from Benchtop to Production

    Begin with ready-to-use workstations or integrate OEM components, so you can scale seamlessly from your R&D bench to full‑scale manufacturing.

View All Ultra-low Volume Solutions

Choose an outcome below to see personalized product recommendations.

Automated workstation

BIOSPOT® Workstation

Specializes in microplate applications, achieving unparalleled accuracy in dispensing nanoliter volumes for compound screening and assay miniaturization.

Automated workstation

BIOSPOT® DX

A flexible spotting platform designed to dispense ultra-low volumes onto virtually any substrate, ideal for biosensors, lateral flow assays, microfluidic devices, and diagnostic chip manufacturing.

Automated workstation

BIOSPOT® ARC

Compact benchtop dispenser for R&D labs, supports up to 2 channels and either 2 microplates or a 190×130 mm flat deck for early-stage assay testing.

Dispensing Technology

PIPEJET® Nano Dispenser

Non-contact, drop-on-demand dispenser for nanoliter volumes using piezo-actuated polymer tips, perfect for precision across a wide range of viscosities in your workflows.

Dispensing Technology

SIJET Pico Dispenser

Delivers picoliter droplets (as low as 150 pL) with non-contact piezo technology, suited for highly miniaturized assays and high-resolution dispensing tasks.

What is ultra-low volume liquid dispensing?

 

Ultra-low volume dispensing refers to the controlled delivery of extremely small liquid volumes, typically in the picoliter to nanoliter range. This precise droplet control enables scientists and engineers to miniaturize workflows, conserve expensive reagents, and increase throughput. 

Low volume dispensing plays a crucial role in high-density assays, biosensor production, and microfluidic device fabrication where space and material use must be minimized without compromising precision.

What are the benefits of nanoliter dispensing?

Only a minimum amounts of valuable compounds (e.g., enzymes, antibodies, inhibitors) are required, saving costs.

Smaller volumes enable denser assay layouts and parallelization.

Exact droplet placement ensures reliable test performance, especially in complex multi-step protocols.

Efficient fluid paths lower sample loss and improve reproducibility.

Consistency in volume and position reduces variability and enhances assay robustness.

Ultra Low Volume Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Services

Hamilton's Dispensing Service offers feasibility testing to evaluate if your liquid and workflow are compatible with our dispensing technology.

Hamilton's Technical Support team is here to provide product trouble-shooting, repair, application support, virtual start-up support, and more.

Installation, set-up, and calibration support directly on-site. Our field service team ensures your sensors and cables are installed and functioning correctly.

Backed by world-class service and support.

For over 75 years, the Hamilton name has been recognized globally for its unwavering commitment to quality. That pledge extends to creating long-term customer partnerships. We're proud to offer in-depth training courses, on-site field support, custom product builds, and so much more.

Let's Talk

Connect with a Hamilton expert to discuss solutions for your workflow. We are here to enable your success.

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