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Solubility

solubility_drug_discovery_4

Solubility is the property of a substance to dissolve and result in a homogenous system. Amongst other parameters, it is used for estimating the druglikeness of a compound.

It strongly influences one of the most important parameters in drug discovery: to achieve the desired concentration of a drug in patients for the desired pharmacological response.

In addition, high aqueous solubility is one of the major goals of drug development, as it allows for easy bioavailability in the body and enables oral application.

Hamilton has experience with automating various assay types for aqueous solubility testing solubility of compounds under a variety of pH conditions, such as the common turbidimetric assays and equilibrium assays.