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Oligonucleotide HPLC

PRP-C18 columns have genuine pH and chemical stability. The stationary phase stands up to prolonged exposure to concentrations as high as 1 M NaOH and 1 M H2SO4, with no measurable decrease in performance. The support does not strip, bleed, or dissolve at any pH. It can therefore perform reliably and reproducibly throughout the extended life of the column, regardless of mobile phase conditions. Unlike a silica C18 column, the PRP-C18 is resistant to temperatures above 100°C.

  • PRP-C18 Columns

  • PRP-C18 Guard Columns

  • PRP-C18 Bulk Resin

Feature Application

Application Examples

Organic compounds including:

small molecules (< 2,000 mw)
amino acids
high pH applications

Tech Center

Specific Applications


Hamilton's knowledge base provides a range of explanatory articles, frequently asked questions, and document downloads.
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