PRP-C18 columns have genuine pH and chemical stability. The stationary phase stands up to prolonged exposure to concentrations as high as 1 M NaOH and 1 M H2SO4, with no measurable decrease in performance. The support does not strip, bleed, or dissolve at any pH. It can therefore perform reliably and reproducibly throughout the extended life of the column, regardless of mobile phase conditions. Unlike a silica C18 column, the PRP-C18 is resistant to temperatures above 100°C.
small molecules (< 2,000 mw)
high pH applications
Separation of Fat Soluble Vitamin K Congeners in Under 6 Minutes (PRP-C18)With the growing utility of the K vitamin series of molecules, a need appears relevant for both food labeling of constituents and for research based separation of the natural and synthetic compounds of vitamin K.
Separation of Selected Components of Ylang-Ylang Oil (PRP-C18)In this study of an essential oil, we have developed an HPLC method for the separation of 6 well-known markers for the determination of purity of Ylang-Ylang oil.
Reversed-Phase Separation of Isoflavones and Mycotoxins in Soy Beans (PRP-C18)Soy beans can contain a fungal metabolite and mycotoxin, Zearalenone (ZEA), which cause an increase in the proliferation of certain tumor cells
Strongly Basic Drug Compounds (PRP-C18)In this study, 9 structurally-diverse, strongly basic drug compounds are resolved in less than 2 minutes using a high pH mobile phase and a fast acetonitrile gradient at 80°C.
HPLC Guard Columns, HPLC Guard CartridgesHPLC guard columns and guard cartridges protect analytical, semi-prep and preparative HPLC columns. They help by removing particulate contaminants and highly absorptive compounds from samples, prolonging column life.
Work with R&D engineers to customize Hamilton parts
Hamilton's "Custom Built" program puts you directly in contact with a Hamilton R&D Engineer to discuss your application and product needs. The engineer will point you to a standard solution or propose a customized solution to meet your needs.Talk to an engineer