Does automated DNA clean-up maintain sequencing data quality compared with manual workflows?

Yes. In this study, automated DNA clean-up and size selection performed using Microlab PuriFY maintained equivalent data quality compared with manual magnetic bead purification workflows.

Automation helps standardize bead mixing, washing, and elution steps across runs and operators. By reducing variability introduced through manual pipetting and handling, automated workflows can improve repeatability while preserving sequencing performance for NGS library preparation and downstream analysis.