NucleoMag® cfDNA

Liquid biopsies, specifically cell-free DNA (cfDNA) analysis, are minimally invasive techniques for genomic profiling with enormous potential for clinical prognostic and diagnostic applications. These techniques serve as tools for assessing biomarkers for cancer profiling, tumor burden monitoring, prenatal testing, or quantification of minimal residual disease during patient follow-up.

The NucleoMag® cfDNA kit is designed for rapid and reliable isolation of circulating cell-free DNA from human plasma, derived from sources such as EDTA blood draw tubes or Cell-Free DNA BCT® Tubes. The kit enables highly efficient recovery of fragmented DNA ≥ 50 bp. Elution can be performed with as little as 50–200 μL, and the purified DNA is ready for use in all common downstream applications like digital droplet PCR or NGS.

Together with Hamilton, MACHEREY‑NAGEL has established its NucleoMag® cfDNA kit on the NIMBUS Presto workstation. In this Application Note, we demonstrate the reliable cfDNA purification from human plasma samples in a fully automated manner for your high-throughput nucleic acid extraction workflow.

Download the Application Note to read on.

Disclaimer: Hamilton Partner's Application Note