cfDNA Purification from up to 96 Plasma Samples Using the Mag-Bind® NAP STAR

Cell-free DNA (cfDNA) has emerged as a revolutionary tool in the realm of molecular diagnostics, offering a non-invasive window into the genetic information of various bodily tissues. The development of cfDNA technology is a large step forward in detecting and profiling circulating biomarkers to derive clinically relevant information. 

However, researchers and clinicians alike face challenges when attempting to extract high-quality cfDNA in a streamlined manner due to its low concentrations and short, fragmented nature. For efficient implementation of applications downstream, a high throughput method for purifying high-quality cfDNA is critical.

To address these obstacles, Omega Bio-tek has developed a high throughput automated workflow configuration to extract cfDNA from ninety-six, 4 mL plasma samples in approximately 3 hours. The Mag-Bind® NAP STAR is an Assay-Ready Workstation specifically configured to run Omega Bio-tek’s Mag-Bind® DNA purification Kits using Hamilton’s Microlab® STAR™. 

Here, we elucidate the methods of the Mag-Bind® NAP STAR using Omega Bio-tek’s Mag-Bind® cfDNA Kit (M3298) and compare its performance to that of extractions performed manually using the same kit.

Disclaimer: Hamilton Partner's App Note