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Automated Spotting of Multiplex Lateral Flow Assays for Blood Group Genotyping Using the BIOSPOT® DX Platform

App Note BIOSPOT Cover

Precision Spotting for Blood Group Genotyping with BIOSPOT® DX

Discover how the BIOSPOT® DX platform enables precise, multiplexed reagent spotting for dry-reagent lateral flow assays (LFAs). This Application Note presents a validated, non-contact workflow for creating allele-specific genotyping strips across seven SNPs in the Kidd, Duffy, and MNS blood group systems—without DNA extraction or complex interpretation.

Key Highlights

  • Reproducible nanoliter spotting: 50 nL droplets of oligonucleotide and protein reagents dispensed with high spatial accuracy across 2×5 LFA matrices.
  • Walk-away assay production: Automated processing with integrated vacuum plate and enclosed deck design minimizes contamination risk and manual variability.
  • Proven concordance: 100% match with reference genotyping data from five donor samples demonstrates system reliability for SNP-based blood group testing.

The BIOSPOT® DX streamlines development of custom LFAs—enabling scalable, reproducible, and contamination-free strip production for personalized diagnostics.

Download the Application Note to read on.