Automating Liquid Biopsy Sample Preparation

Hamilton application note titled "Automated Liquid Biopsy Sample Preparation with the nRichDX Revolution System on the Hamilton Microlab STAR"

Automated Liquid Biopsy Sample Preparation with the nRichDX Revolution® System on the Hamilton Microlab® STAR

Liquid biopsy workflows require efficient recovery of rare biomarkers with maintained consistency across increased sample volumes. This application note demonstrates how the nRichDX Revolution Plus Sample Prep System and Hamilton Microlab STAR automate wash and elution steps for cfDNA, cfRNA, cfTNA, and CTC workflows. This integrated solution delivers scalable, reproducible sample preparation while reducing manual intervention for liquid biopsy laboratories. 

Key Takeaways:

  • Scalable extraction: Automated processing maintained strong linearity across increasing sample volumes, with an R² of 0.9952 compared with 0.9393 for manual processing. 
  • Reliable reproducibility: Stable Ct values and approximately 1.1% CV demonstrated consistent performance across batch sizes up to 96 samples. 
  • Contamination-free processing: Checkerboard testing showed 100% concordance with no detectable carryover between positive and negative samples.

 
Read the Full Application Note to Learn More.