Automated Clone Picking with Cell Care STAR: Scalable and Reproducible Cell Line Generation

Hamilton Cell Care STAR automated clone picking application note cover with workflow diagram and bullet points

Scale Cell Line Development with Automated Clone Picking

Scaling clonal cell line development requires consistent selection and expansion with minimal manual intervention. This application note demonstrates how Cell Care STAR™ automates clone selection, passaging, and expansion using image-based evaluation and the dedicated “Clone Picking” work step. The workflow supports reproducible cell distribution, traceable processing, and reduced cross-contamination risk between clonal lines.

Key Takeaways

  • Targeted clone selection: Image-based evaluation and user-defined worklists enable selective expansion of individual clones.
  • Reproducible expansion: Automated passaging from 96- to 24-well plates delivered uniform cell distribution across selected clones.
  • Traceable processing: Well-specific handling and fresh tips between wells minimize cross-contamination risk while supporting workflow documentation.

Read the Full Application Note to Learn More.