The Premiere Solution for NGS

The NGS STAR assay-ready workstation is a comprehensive solution for next-generation sequencing (NGS) applications from whole genome to whole transcriptome sequencing and targeted sequencing applications.

The fully automated library preparation system can be customized for use with assay chemistries from leading industry partners, processing 96 libraries at once.

Features and Benefits of the NGS STAR

Fully Optimized NGS Solution

The NGS STAR is an affordable and versatile system that delivers substantial value to our customers. The NGS library prep workflows we developed with industry-leading partners, including:

  • Illumina
  • Integrated DNA Technologies - IDT
  • New England BioLabs
  • Oxford Nanopore Technologies
  • Pacific Biosciences
  • Roche KAPA
  • Thermo Fisher Scientific
  • Twist Biosciences

Have specific questions, or don’t see a desired provider on this list? Contact our dedicated application experts, who will provide
high quality guidance and translate specific needs into reliable and efficient automated workflows.

NGS STAR deck layout with CO-RE grippers

Individualized Flexibility

The NGS STAR uses an open deck layout so that every system is fine-tuned to the lab’s specific NGS workflow, throughput, and assay needs. At the same time, the system is easily updated to keep pace with protocol updates, or as requirements evolve over time. Our customers can also choose from a wide range of options to customize their system. The NGS STAR is available as an open or enclosed solution, with a variety of cooling and airflow configurations.

Precise, Repeatable Liquid Handling

Air displacement pipetting using Hamilton tips with CO-RE (Compressed O-Ring Expansion) technology provides superior measurement accuracy, precision, and reproducibility without tip distortion or aerosol generation during tip pick-up and ejection.

Hands-Free, Hassle-Free Operation

As a fully automated system, NGS STAR significantly reduces the number of cumbersome preparation steps required by current methods during runs of 1 to 96 samples. User-friendly software guides operators through the automated process, and automated barcode verification ensures proper placement of samples, reagents, plates, and tips. Each step in the aspirate and dispense process is continuously monitored for accuracy so that your lab can remain confident about getting consistent results throughout its operation.


All specifications are based on the Microlab STAR.

Length31.2 in (795 mm)
Width65.6 in (1664 mm)
Height35.6 in (903 mm)

Biologically Tested Methods for NGS STAR

Elevate NGS Precision with Biologically Tested Methods

Experience the pinnacle of Next-Generation Sequencing (NGS) precision. Our NGS STAR platform is engineered for discerning laboratory experts, offering biologically tested methods.

With our rigorous validation processes, you can expect:

Scientific Excellence: Collaborative development with industry experts ensures the highest scientific standards.
Unwavering Reproducibility: Achieve consistent, reliable results, eliminating variability.
Efficient Workflows: Streamlined NGS processes let you focus on your clinical research.

Discover biologically tested methods that redefine precision with NGS STAR.

Ready to enhance your NGS research? Contact us for details.

  • Targeted Enrichment for NGS Automation

    Do you find traditional, laborious DNA sequencing methods inefficient and unreliable? Targeted enrichment is a revolutionary technique that makes it possible to isolate specific regions of the genome for more accurate sequencing results. Our targeted enrichment methods utilize cutting-edge technology to provide you with high-quality results, saving you time, money, and resources. Say goodbye to traditional shotgun sequencing and hello to targeted enrichment - the future of genetic analysis.

    Check out some of the targeted enrichment methods we offer:

    Targeted Enrichment

    Agilent SureSelect XT HS2 (DNA and RNA System)

    Agilent SureSelect XT Low Input Dual Index

    IDT xGen enrichment for Illumina (Exome Research Panel)

    Illumina AmpliSeq Custom Panels

    Illumina COVIDSeq Illumina TruSeq DNA PCR-Free

    Illumina DNA Prep with Enrichment (Exome)

    Illumina TruSeq RNA Exome

    Illumina TruSight Oncology 500

    Illumina TruSight Oncology 500 HT

    Illumina TruSight RNA Fusion

    Illumina TruSight Tumor 170

    Ilumina 16S rRNA Seq
    Illumina DNA Prep with Exome 2.5 Enrichment
    Illumina TruSight Oncology 500 HRD

    NEBNext ARTIC SARS-CoV-2 FS Library Prep

    Oxford Nanopore PCR tiling (SARS-CoV-2, ARTIC protocol)

    Oxford Nanopore PCR tiling of SARS-CoV-2 ('Midnight Kit' version)

    Paragon Genomics CleanPlex-SARS-CoV-2-Flex-Panel


    QIAGEN QIAseq Multimodal Panel

    QIAGEN QIAseq Multimodal Panel HT

    QIAGEN QIAseq SARS-CoV-2 Primer Panel & Qiagen QIAseq FX DNA

    QIAGEN QIAseq Targeted DNA Panel (multiple panels)

    QIAGEN QIAseq Targeted DNA Pro Panels

    QIAGEN QIAseq Targeted DNA Pro Panels (very small panels)

    Roche Avenio Tumor Tissue CGP Kit

    Roche KAPA HyperCap Workflow v3.0

    Thermo Fisher Scientific AgriSeq HTS Library Kit

    Twist Bioscience Human Core Exome

    Twist Bioscience SARS-CoV-2 Research Panel

  • Whole Genome Sequencing

    Are you searching for a way to gain a complete understanding of an organism's genetic blueprint? With our state-of-the-art sequencing technologies and methodologies, we can analyze an organism's entire genome to provide an unprecedented amount of detailed genetic information.

    We work with you to customize the sequencing process by tailoring it to meet your unique research goals—from sample preparation to data analysis. We utilize a variety of methods and technologies, including:

    Whole Genome Sequencing

    Illumina TruSeq Nano DNA

    Illumina Nextera XT

    Illumina DNA Prep

    Illumina DNA PCR-Free Prep

    Illumina TruSeq DNA PCR-Free

    NEBNext Ultra II DNA Library Prep

    NEBNext Enzymatic Methyl-Seq

    Oxford Nanopore Genomic DNA by Ligation (SQK-LSK109-XL)

    Oxford Nanopore Genomic DNA by Ligation (SQK-LSK114-XL)

    Oxford Nanopore Genomics Multiplex Ligation Sequencing (SQK-MLK111.96-XL)
    PacBio Whole Genome and Metagenome Libraries using SMRTbell prep kit 3.0
    PacBio HiFi prep Kit 96
    PacBio HiFi plex prep Kit 96

    Revvity NEXTFLEX Cell Free DNA-Seq Library Prep Kit 2.0


    Roche KAPA HyperPrep

    Roche KAPA HyperPlus

  • Transcriptome Sequencing

    Want to dive deeper into the genetic makeup of your samples? Transcriptome sequencing is the key to gene expression and regulation! This advanced technique allows you to sequence and analyze all of your RNA transcript samples, providing invaluable insight into how genes are turned on or off.

    Our state-of-the-art transcriptome sequencing services utilize cutting-edge technology to provide you with accurate and reliable data. We offer a range of methods to meet your specific research needs, including:

    Transcriptome Sequencing

    Illumina TruSeq Stranded Total RNA

    Illumina Stranded Total RNA Prep Ligation with Ribo-Zero Plus

    Illumina TruSeq Stranded mRNA

    Illumina Stranded mRNA Prep and Ligation

    Lexogen QuantSeq 3´mRNA-Seq Library for Illumina

    NEBNext Ultra II Directional RNA (rRNA depletion)

    NEBNext Ultra II Directional RNA (Poly(A) mRNA isolation)

    Roche KAPA RNA HyperPrep

    Roche KAPA mRNA HyperPrep

    Takara SMART-Seq HT

    Our team of experts will work with you to customize the sequencing process and provide you with high-quality data and comprehensive analysis. With our transcriptome sequencing services, you can unlock a wealth of information about gene expression and regulation, leading to new insights into disease mechanisms and potential therapeutic targets.

    Contact us today to learn more about our transcriptome sequencing services and how we can help you advance your research goals and translate the latest genomics research into actionable insights.

Additional Resources for the Hamilton NGS STAR

Download NGS STAR Flyer now
See all Hamilton Robotics Automated Liquid Handlers
View all of Hamilton's Assay Ready Workstations
Check out the Hamilton Microlab STAR automated liquid handler

Specific Applications

Contact our customer service 24 hours a day via email.

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Whether you need a new instrument or support for one already in the lab, Hamilton is here to support you. Dedicated staff around the world are ready to respond to your request.

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