NGS STAR

The Premiere Solution for NGS
The NGS STAR assay ready workstation is a comprehensive solution for next-generation sequencing (NGS) applications from whole genome to whole transcriptome sequencing and targeted sequencing applications. Fully automated library preparation can be optimized for use with assay chemistries from leading industry partners, with throughputs up to 96 sample libraries processed at once.
Features and Benefits

Fully Optimized NGS Solution
The NGS STAR is ideal for multiple automated NGS library preparations. Each NGS application is optimized and qualified in collaboration with industry-leading partners such as:
- Illumina
- Roche-KAPA
- PacBio
- IDT
- Twist
- Thermo Fisher Scientific
- New England BioLabs
- SWIFT
Have specific questions, or don’t see a desired provider on this list? Contact our dedicated application experts, who will provide
high quality guidance and translate specific needs into reliable and efficient automated workflows.

Individualized Flexibility
The NGS STAR uses an open deck layout so that every system is fine-tuned to the lab’s specific NGS workflow, throughput and assay needs. At the same time, the system is easily updated to keep pace with protocol updates, or as requirements evolve over time.

Precise, Repeatable Liquid Handling
Air displacement pipetting using Hamilton tips with CO-RE (Compressed O-Ring Expansion) technology provides superior measurement accuracy, precision, and reproducibility without tip distortion or aerosol generation during tip pick-up and ejection.

Hands-Free, Hassle-Free Operation
As a fully walkaway system, NGS STAR significantly reduces cumbersome and user- or sample-variable preparation steps during runs of 1 to 96 samples. User-friendly software guides operators through the automated process, and automated barcode verification ensures proper placement of samples, reagents, plates and tips. Each aspirate and dispense step is dynamically tracked, for confidence that the indexed and multiplexed samples are processed according to the worklist and highly reproducible, even across different sites.
Specifications
All specifications are based on the Microlab STAR.
Dimensions | |
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Length | 31.2 in (795 mm) |
Width | 65.6 in (1664 mm) |
Height | 35.6 in (903 mm) |
Biologically Tested Methods for NGS STAR
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Targeted Enrichment
Are you tired of laborious and inefficient genetic sequencing methods? Say hello to targeted enrichment! This revolutionary technique allows for specific regions of DNA to be isolated and enriched, resulting in more accurate and reliable sequencing data. Our targeted enrichment methods utilize cutting-edge technology to provide you with high-quality results, saving you time, money, and resources. Say goodbye to traditional shotgun sequencing and hello to targeted enrichment - the future of genetic analysis.
Check out some of the targeted enrichment methods we offer:
Targeted Enrichment Whole Genome Sequencing Agilent SureSelect XT HS2 (DNA and RNA System)
Agilent SureSelect XT Low Input Dual Index
IDT xGen enrichment for Illumina (Exome Research Panel)
Illumina AmpliSeq Custom Panels
Illumina COVIDSeq Illumina TruSeq DNA PCR-Free
Illumina DNA Prep with Enrichment (Exome)
Illumina TruSeq RNA Exome
Illumina TruSight Oncology 500
Illumina TruSight Oncology 500 HT
Illumina TruSight RNA Fusion
Illumina TruSight Tumor 170
llumina 16S rRNA Seq NEBNext ARTIC SARS-CoV-2 FS Library Prep
Oxford Nanopore PCR tiling (SARS-CoV-2, ARTIC protocol)
Oxford Nanopore PCR tiling of SARS-CoV-2 ('Midnight Kit' version)
PacBio Whole Genome and metagenome libraries using SMRTbell prep kit 3.0 Transcriptome Sequencing
Paragon Genomics CleanPlex-SARS-CoV-2-Flex-Panel
Qiagen QIAseq DIRECT SARS-CoV-2 Kit
Qiagen QIAseq Multimodal Panel
Qiagen QIAseq Multimodal Panel HT
Qiagen QIAseq SARS-CoV-2 Primer Panel & Qiagen QIAseq FX DNA
Qiagen QIAseq Targeted DNA Panel (multiple panels)
Qiagen QIAseq Targeted DNA Pro Panels
Roche Avenio Tumor Tissue CGP Kit
Roche KAPA HyperCap Workflow v3.0
Twist Bioscience Human Core Exome
Twist Bioscience SARS-CoV-2 Research Panel
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Whole Genome Seqeuncing
Are you searching for a way to gain a complete understanding of an organism's genetic blueprint? Look no further than whole genome sequencing! Our cutting-edge technology and methodologies make it possible to sequence an organism's complete genome, providing a wealth of detailed genetic information.
Our team of experts will work with you to customize the sequencing process to meet your unique research goals, from sample preparation to data analysis. We utilize a variety of methods to ensure the highest quality results, including:Whole Genome Sequencing
Illumina TruSeq Nano DNA
Illumina Nextera XT
Illumina DNA Prep
Illumina DNA PCR-Free Prep
NEBNext Ultra II DNA Library Prep
NEBNext Enzymatic Methyl-Seq
Oxford Nanopore Genomic DNA by Ligation (SQK-LSK109-XL)
Oxford Nanopore Genomic DNA by Ligation (SQK-LSK114-XL)
Perkin Elmer NEXTFLEX Cell Free DNA-Seq Library Prep Kit 2.0
Qiagen QIAseq FX DNA
Roche KAPA HyperPrep
Roche KAPA HyperPlus
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Transcriptome Sequencing
Want to dive deeper into the genetic makeup of your samples? Transcriptome sequencing is the key! This advanced technique allows you to sequence and analyze the complete set of RNA transcripts in your samples, providing invaluable insight into gene expression and regulation.
Our state-of-the-art transcriptome sequencing services utilize cutting-edge technology to provide you with accurate and reliable data. We offer a range of methods to meet your specific research needs, including:
Transcriptome Sequencing
Illumina TruSeq Stranded Total RNA
Illumina Stranded Total RNA Prep Ligation with Ribo-Zero Plus
Illumina TruSeq Stranded mRNA
Illumina Stranded mRNA Prep and Ligation
Lexogen QuantSeq 3´mRNA-Seq Library for Illumina
NEBNext Ultra II Directional RNA (rRNA depletion)
NEBNext Ultra II Directional RNA (Poly(A) mRNA isolation)
Roche KAPA RNA HyperPrep
Roche KAPA mRNA HyperPrep
Takara SMART-Seq HT
Our team of experts will work with you to customize the sequencing process and provide you with high-quality data and comprehensive analysis. With our transcriptome sequencing services, you can unlock a wealth of information about gene expression and regulation, leading to new insights into disease mechanisms and potential therapeutic targets.
Contact us today to learn more about our transcriptome sequencing services and how we can help you advance your research goals.
Additional Resources for the NGS STAR
See all Hamilton Robotics Automated Liquid Handlers
View all of Hamilton's Assay Ready Workstations
Check out the Hamilton Microlab STAR automated liquid handler
Learn more about the AutoLys STAR
Specific Applications
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Fully Automated Library Quantification for Illumina® Sequencing on the NGS STAR
In this case study, we describe a newly developed automated method for the quantification of Illumina NGS libraries using the KAPA Library Quantification Kit on the NGS STAR for Library Prep. -
TruSight Tumor 170 Automated on the NGS STAR for Illumina Library Prep
Hamilton Robotics and Illumina, Inc have partnered to automate the TruSight Tumor 170 library preparation kit on the NGS STAR. TruSight Tumor 170 simultaneously analyzes DNA and RNA while covering a wide range of genes and variant types. TruSight Tumor 170 is capable of producing accurate results from low-quality formalin-fixed paraffin-embedded (FFPE) samples with a minimum input requirement of 40 ng. The design of the NGS STAR, as a single configuration, enables implementation of additional methods as well as future Illumina protocols using the TruSight Oncology workflow as they are released. -
Whole Genome and Transcriptome Analysis for Leukemia Diagnostics
The rationale behind the automation of the assay is mainly in terms of a quality improvement and enhancement of productivity, provided by minimizing the bias that might be otherwise introduced by manual library preparation. Moreover, the automated system is sufficiently flexible to adapt and therefore easily meet evolving needs. -
NEOonsite assays automated on the Hamilton NGS STAR
In this application note, we discuss the results and findings from a customer project to automate NEOonsite assays using Hamilton’s NGS STARTM workstation, aiming for a reduction of hands-on time and number of user interventions, while keeping a high level of reproducibility.

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Whether you need a new instrument or support for one already in the lab, Hamilton is here to support you. Dedicated staff around the world are ready to respond to your request.
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