NGS STAR

The Premiere Solution for NGS

The NGS STAR assay ready workstation is a comprehensive solution for next-generation sequencing (NGS) applications from whole genome to whole transcriptome sequencing and targeted sequencing applications. Fully automated library preparation can be optimized for use with assay chemistries from leading industry partners, with throughputs up to 96 sample libraries processed at once.

Features and Benefits

Fully Optimized NGS Solution

The NGS STAR is ideal for multiple automated NGS library preparations. Each NGS application is optimized and qualified in collaboration with industry-leading partners such as:

  • Illumina
  • Roche-KAPA
  • PacBio
  • IDT
  • Twist
  • Thermo Fisher Scientific
  • New England BioLabs
  • SWIFT

Have specific questions, or don’t see a desired provider on this list? Contact our dedicated application experts, who will provide
high quality guidance and translate specific needs into reliable and efficient automated workflows.

Individualized Flexibility

The NGS STAR uses an open deck layout so that every system is fine-tuned to the lab’s specific NGS workflow, throughput and assay needs. At the same time, the system is easily updated to keep pace with protocol updates, or as requirements evolve over time.

Precise, Repeatable Liquid Handling

Air displacement pipetting using Hamilton tips with CO-RE (Compressed O-Ring Expansion) technology provides superior measurement accuracy, precision, and reproducibility without tip distortion or aerosol generation during tip pick-up and ejection.

Hands-Free, Hassle-Free Operation

As a fully walkaway system, NGS STAR significantly reduces cumbersome and user- or sample-variable preparation steps during runs of 1 to 96 samples. User-friendly software guides operators through the automated process, and automated barcode verification ensures proper placement of samples, reagents, plates and tips. Each aspirate and dispense step is dynamically tracked, for confidence that the indexed and multiplexed samples are processed according to the worklist and highly reproducible, even across different sites.

Specifications

All specifications are based on the Microlab STAR.

Dimensions
Length31.2 in (795 mm)
Width65.6 in (1664 mm)
Height35.6 in (903 mm)

Biologically Tested Methods for NGS STAR

  • Targeted Enrichment

    Are you tired of laborious and inefficient genetic sequencing methods? Say hello to targeted enrichment! This revolutionary technique allows for specific regions of DNA to be isolated and enriched, resulting in more accurate and reliable sequencing data. Our targeted enrichment methods utilize cutting-edge technology to provide you with high-quality results, saving you time, money, and resources. Say goodbye to traditional shotgun sequencing and hello to targeted enrichment - the future of genetic analysis.

    Check out some of the targeted enrichment methods we offer:

    Targeted Enrichment Whole Genome Sequencing

    Agilent SureSelect XT HS2 (DNA and RNA System)

    Agilent SureSelect XT Low Input Dual Index

    IDT xGen enrichment for Illumina (Exome Research Panel)

    Illumina AmpliSeq Custom Panels

    Illumina COVIDSeq Illumina TruSeq DNA PCR-Free

    Illumina DNA Prep with Enrichment (Exome)

    Illumina TruSeq RNA Exome

    Illumina TruSight Oncology 500

    Illumina TruSight Oncology 500 HT

    Illumina TruSight RNA Fusion

    Illumina TruSight Tumor 170

    llumina 16S rRNA Seq

    NEBNext ARTIC SARS-CoV-2 FS Library Prep

    Oxford Nanopore PCR tiling (SARS-CoV-2, ARTIC protocol)

    Oxford Nanopore PCR tiling of SARS-CoV-2 ('Midnight Kit' version)

    PacBio Whole Genome and metagenome libraries using SMRTbell prep kit 3.0 Transcriptome Sequencing

    Paragon Genomics CleanPlex-SARS-CoV-2-Flex-Panel

    Qiagen QIAseq DIRECT SARS-CoV-2 Kit

    Qiagen QIAseq Multimodal Panel

    Qiagen QIAseq Multimodal Panel HT

    Qiagen QIAseq SARS-CoV-2 Primer Panel & Qiagen QIAseq FX DNA

    Qiagen QIAseq Targeted DNA Panel (multiple panels)

    Qiagen QIAseq Targeted DNA Pro Panels

    Roche Avenio Tumor Tissue CGP Kit

    Roche KAPA HyperCap Workflow v3.0

    Twist Bioscience Human Core Exome

    Twist Bioscience SARS-CoV-2 Research Panel

  • Whole Genome Seqeuncing

    Are you searching for a way to gain a complete understanding of an organism's genetic blueprint? Look no further than whole genome sequencing! Our cutting-edge technology and methodologies make it possible to sequence an organism's complete genome, providing a wealth of detailed genetic information.
    Our team of experts will work with you to customize the sequencing process to meet your unique research goals, from sample preparation to data analysis. We utilize a variety of methods to ensure the highest quality results, including:

    Whole Genome Sequencing

    Illumina TruSeq Nano DNA

    Illumina Nextera XT

    Illumina DNA Prep

    Illumina DNA PCR-Free Prep

    NEBNext Ultra II DNA Library Prep

    NEBNext Enzymatic Methyl-Seq

    Oxford Nanopore Genomic DNA by Ligation (SQK-LSK109-XL)

    Oxford Nanopore Genomic DNA by Ligation (SQK-LSK114-XL)

    Perkin Elmer NEXTFLEX Cell Free DNA-Seq Library Prep Kit 2.0

    Qiagen QIAseq FX DNA

    Roche KAPA HyperPrep

    Roche KAPA HyperPlus

  • Transcriptome Sequencing

    Want to dive deeper into the genetic makeup of your samples? Transcriptome sequencing is the key! This advanced technique allows you to sequence and analyze the complete set of RNA transcripts in your samples, providing invaluable insight into gene expression and regulation.

    Our state-of-the-art transcriptome sequencing services utilize cutting-edge technology to provide you with accurate and reliable data. We offer a range of methods to meet your specific research needs, including:

    Transcriptome Sequencing

    Illumina TruSeq Stranded Total RNA

    Illumina Stranded Total RNA Prep Ligation with Ribo-Zero Plus

    Illumina TruSeq Stranded mRNA

    Illumina Stranded mRNA Prep and Ligation

    Lexogen QuantSeq 3´mRNA-Seq Library for Illumina

    NEBNext Ultra II Directional RNA (rRNA depletion)

    NEBNext Ultra II Directional RNA (Poly(A) mRNA isolation)

    Roche KAPA RNA HyperPrep

    Roche KAPA mRNA HyperPrep

    Takara SMART-Seq HT


    Our team of experts will work with you to customize the sequencing process and provide you with high-quality data and comprehensive analysis. With our transcriptome sequencing services, you can unlock a wealth of information about gene expression and regulation, leading to new insights into disease mechanisms and potential therapeutic targets.
    Contact us today to learn more about our transcriptome sequencing services and how we can help you advance your research goals.

Additional Resources for the NGS STAR

See all Hamilton Robotics Automated Liquid Handlers
View all of Hamilton's Assay Ready Workstations
Check out the Hamilton Microlab STAR automated liquid handler
Learn more about the AutoLys STAR

Specific Applications

Featured Application

Oxford Nanopore ARTIC SARS-CoV-2 Protocol with Native Barcoding Expansion

Identification and tracking of pathogen variation has gained substantial importance in the ongoing COVID-19 pandemic. To support the rapidly expanding user needs to process higher sample numbers for SARS-CoV-2 sequencing, Oxford Nanopore Technologies has developed a partially automated version of the end-to-end ARTIC SARS-CoV-2 PCR Tiling protocol, in collaboration with Hamilton. This increases the throughput of this protocol while reducing hands-on time needed. Automation helps to increase consistency and reproducibility of results between runs.

  • Fully Automated Library Quantification for Illumina® Sequencing on the NGS STAR

    In this case study, we describe a newly developed automated method for the quantification of Illumina NGS libraries using the KAPA Library Quantification Kit on the NGS STAR for Library Prep.

  • TruSight Tumor 170 Automated on the NGS STAR for Illumina Library Prep

    Hamilton Robotics and Illumina, Inc have partnered to automate the TruSight Tumor 170 library preparation kit on the NGS STAR. TruSight Tumor 170 simultaneously analyzes DNA and RNA while covering a wide range of genes and variant types. TruSight Tumor 170 is capable of producing accurate results from low-quality formalin-fixed paraffin-embedded (FFPE) samples with a minimum input requirement of 40 ng. The design of the NGS STAR, as a single configuration, enables implementation of additional methods as well as future Illumina protocols using the TruSight Oncology workflow as they are released.

  • Whole Genome and Transcriptome Analysis for Leukemia Diagnostics

    The rationale behind the automation of the assay is mainly in terms of a quality improvement and enhancement of productivity, provided by minimizing the bias that might be otherwise introduced by manual library preparation. Moreover, the automated system is sufficiently flexible to adapt and therefore easily meet evolving needs.

  • NEOonsite assays automated on the Hamilton NGS STAR

    In this application note, we discuss the results and findings from a customer project to automate NEOonsite assays using Hamilton’s NGS STARTM workstation, aiming for a reduction of hands-on time and number of user interventions, while keeping a high level of reproducibility.
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