BIOSPOT® Workstation
Nanoliter precision
7–70 nL
Drop-on-demand
Unparalleled precision
<3% CV
High reproducibility
Auto-calibration
No liquid classes
Rapid downtime
High-precision dispensing, low-volume efficiency
BIOSPOT® delivers reproducible nanoliter dispensing for microplate workflows, so you can minimize reagent use and achieve consistent, high-quality results for compound screening and assay development.
References
Next-Level Dose-Response Assays with BIOSPOT: Precision and Efficiency in Compound Curves
BIOSPOT® simplifies dose-response curve generation with the…
BIOSPOT® Workstation: Elevating Cell-Based Toxicity Assays with Nanoliter Precision
Automate dose-response curves with BIOSPOT®: precise…
BIOSPOT Workstation
Reproducible nanoliter dispensing with low working volume
BIOSPOT delivers consistent nanoliter dispensing as low as 7 nL with CVs under 3%, ensuring high reproducibility for IC₅₀ curves, compound toxicity profiling, and drug target screening. Its low working volume minimizes reagent consumption and dead volume, making it ideal for conserving precious or expensive reagents in compound library workflows.
Intelligent protocol design with LifeLAB software
integrated LifeLAB software optimizes dispensing workflows by suggesting the most efficient source plate layout and calibrating volumes for precise delivery. It leverages high-frequency droplet generation to accelerate run times, helping labs scale throughput without compromising accuracy.
Flexible deck design and automation integration
BIOSPOT features a 6-position deck with configurable source and target plates, enabling advanced applications such as sequential dosing and sample recovery. It integrates seamlessly with Hamilton’s Microlab STAR platform, allowing volume flexibility from 7 nL to 5 mL and supporting automated workflows across drug discovery and assay development.
Common applications Cell Biology, Cell-Based Assays
Featured Technologies
-
Ultra-Low VolumePIPEJET®
PIPEJET® non-contact nanoliter dispensing technology
-
Ultra-Low VolumeSMARTDROP®
For automated volume calibration
Dispense with precision from 7 to 70 nL for consistently accurate screening results. Reproducibility under 3% CV ensures reliable compound screening results.
BIOSPOT operates with only a few microliters per channel, drastically reducing waste while maintaining high assay performance.
Just set your target layout, and LifeLAB software automatically handles plate setup and drop calibration. It calculates the fastest, most efficient source plate setup and drop calibration.
Use up to 6 microplates as a source or target. Run multiple steps—aspiration, dispensing, retrieval, and nozzle washing, all in one seamless process.
Integrate BIOSPOT with the Hamilton STAR platform to enable workflows from 7 nL to 5 mL in a single automated environment.
Built for Miniaturized Assays
The BIOSPOT Workstation combines cutting-edge dispensing technology with intuitive automation to support miniaturized workflows in microtiter plates. From dose-response studies to cell-based assays, BIOSPOT® delivers nanoliter accuracy with ultra-low working volumes and minimal reagent waste.
1
Nanoliter drop control
Dispense between 7 to 70 nL per droplet with exceptional accuracy using PIPEJET®, our drop-on-demand non-contact technology.
2
SMARTDROP® calibration
Handles diverse liquid classes and adjusts automatically to maintain consistent volume delivery across runs.
3
6-position plate deck
Hold up to six microplates at once. Each plate can function independently as a source or target to fit your workflow.
4
Built-In Ionizer
Reduces electrostatic interference during dispensing by neutralizing surface charges on microtiter plates—improving droplet stability, accuracy, and pattern consistency in ultra-low volume workflows.
5
Intelligent dispensing Interface
The user interface recommends optimal plate layout and calibrates the best drop increment to maximize speed and precision.
BIOSPOT Workstation: Automated Nanoliter Compound Management
Discover how the BIOSPOT Workstation streamlines compound management with nanoliter precision from aspiration and calibration to non-contact dispensing and compound recovery.
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BIOSPOT® Workstation Specifications
BIOSPOT® Workstation Specifications
PrintSystem Dimensions
- Height
- 50 cm (1 ft, 7.69 in)
- Width
- 58 cm (1 ft, 10.83 in)
- Depth
- 90 cm (2 ft, 11.43 in)
Dispensing Configuration
- PIPEJET
- 8
- SIJET
- n/a
- VALVEJET
- n/a
- Maximum Supported Configuration
- 8
- Channel Spacing
- Standard 9mm
Deck Configuration & Capacity
- Capacity (ANSI/SLAS Plates)
- 6
- Aspiration from Source Plate 1
- Yes
Process Control
- SMARTDROP
- Included
- TOPVIEW
- Included
- Ionizer
- Included
Positional Accuracy & Movement
- Absolute Positioning Accuracy
- 50 µm
- Precision / Step Width
- 10 µm
- Axis Speed
- X/Y: 250 mm/s ; Z: 30 mm/s
Control & Software Environment
- Computer
- Integrated
- Software
- LifeLAB
1 Aspiration from source plate; also supports dispensing pipe cleaning when enabled.
Support your entire workflow with Hamilton's integrated products.
Integrate BIOSPOT® with Microlab® STAR to automate workflows from nanoliter to milliliter volumes. This setup combines high-precision dispensing and high-throughput pipetting, enabling seamless transitions between assay miniaturization and bulk liquid handling.
Unlock End-to-End Liquid Handling
Link your Hamilton BIOSPOT to a our Microlab® STAR or Microlab Vantage liquid handling system to automate workflows from nanoliter to milliliter seamlessly bridging ultra-low and standard volume handling.
BIOSPOT® Workstation Resources
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
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Services
Hamilton's Technical Support team is here to provide product trouble-shooting, repair, application support, virtual start-up support, and more.
Installation, set-up, and calibration support directly on-site. Our field service team ensures your sensors and cables are installed and functioning correctly.
Preventative maintenance and regular service contracts. Schedule on-site service dates to ensure your sensors are properly maintained and your process is optimized.
Hamilton's Dispensing Service offers feasibility testing to evaluate if your liquid and workflow are compatible with our dispensing technology.
Backed by world-class service and support.
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