NGS STAR for Library Prep | NGS STAR | Hamilton Company

The Premiere Solution for NGS

The NGS STAR for Library Prep assay ready workstation is a comprehensive solution for next-generation sequencing (NGS) applications from whole genome to whole transcriptome sequencing and targeted sequencing applications. Fully automated library preparation can be optimized for use with assay chemistries from leading industry partners, with throughputs up to 96 sample libraries processed at once.

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Features and Benefits

Fully Optimized NGS Solution

The NGS STAR for Library Prep is ideal for multiple automated NGS library preparations. Each NGS application is optimized and qualified in collaboration with industry-leading partners such as:

Illumina
Roche-KAPA
PacBio
IDT
Twist
Thermo Fisher Scientific
New England BioLabs
SWIFT

Have specific questions, or don’t see a desired provider on this list? Contact our dedicated application experts, who will provide
high quality guidance and translate specific needs into reliable and efficient automated workflows.

Individualized Flexibility

The NGS STAR for Library Prep uses an open deck layout so that every system is fine-tuned to the lab’s specific NGS workflow, throughput and assay needs. At the same time, the system is easily updated to keep pace with protocol updates, or as requirements evolve over time.

Precise, Repeatable Liquid Handling

Air displacement pipetting using Hamilton tips with CO-RE (Compressed O-Ring Expansion) technology provides superior measurement accuracy, precision, and reproducibility without tip distortion or aerosol generation during tip pick-up and ejection.

Hands-Free, Hassle-Free Operation

As a fully walkaway system, NGS STAR for Library Prep significantly reduces cumbersome and user- or sample-variable preparation steps during runs of 1 to 96 samples. User-friendly software guides operators through the automated process, and automated barcode verification ensures proper placement of samples, reagents, plates and tips. Each aspirate and dispense step is dynamically tracked, for confidence that the indexed and multiplexed samples are processed according to the worklist and highly reproducible, even across different sites.

Specifications

All specifications are based on the Microlab STAR.

Dimensions
Length	31.2 in (795 mm)
Width	65.6 in (1664 mm)
Height	35.6 in (903 mm)

Common NGS Library Prep Kits and Available Hamilton Methods

Library Prep Kit	Method Availability
Agilent SureSelect XT	Method available
IDT xGen Enrichment	Method qualified by IDT
Illumina 16S rRNA	Method qualified by Illumina
Illumina Nextera DNA Flex	Method in development
Illumina Nextera Rapid Capture	Method available
Illumina Nextera XT DNA	Method qualified by Illumina
Illumina Nextera Flex for Enrichment	Method qualified by Illumina
Illumina TruSeq DNA PCR-Free	Method available
Illumina TruSeq Nano DNA	Method qualified by Illumina
Illumina TruSeq RNA Exome	Method qualified by Illumina
Illumina TruSeq Stranded mRNA	Method qualified by Illumina
Illumina TruSeq Stranded Total RNA	Method qualified by Illumina
Illumina TruSight Cardio	Method available
Illumina TruSight One	Method available
Illumina TruSight RNA Fusion	Method available
Illumina TruSight Rapid Capture	Method available
Illumina TruSight Tumor 170	Method qualified by Illumina
Roche NimbleGen Target Capture	Method qualified by Roche
Roche/KAPA HyperPrep	Method qualified by Roche
Roche/KAPA HyperPlus	Method qualified by Roche
Roche/KAPA HyperCap	Method qualified by Roche
KAPA Library Quantification Kit for Illumina	Method qualified by Roche

Additional Resources for the NGS STAR for Library Prep

See all Hamilton Robotics Automated Liquid Handlers
View all of Hamilton's Assay Ready Workstations
Check out the Hamilton Microlab STAR automated liquid handler
Learn more about the AutoLys STAR

Specific Applications

Featured Application

Oxford Nanopore ARTIC SARS-CoV-2 Protocol with Native Barcoding Expansion

Identification and tracking of pathogen variation has gained substantial importance in the ongoing COVID-19 pandemic. To support the rapidly expanding user needs to process higher sample numbers for SARS-CoV-2 sequencing, Oxford Nanopore Technologies has developed a partially automated version of the end-to-end ARTIC SARS-CoV-2 PCR Tiling protocol, in collaboration with Hamilton. This increases the throughput of this protocol while reducing hands-on time needed. Automation helps to increase consistency and reproducibility of results between runs.

Fully Automated Library Quantification for Illumina® Sequencing on the NGS STAR

In this case study, we describe a newly developed automated method for the quantification of Illumina NGS libraries using the KAPA Library Quantification Kit on the NGS STAR for Library Prep.
TruSight Tumor 170 Automated on the NGS STAR for Illumina Library Prep

Hamilton Robotics and Illumina, Inc have partnered to automate the TruSight Tumor 170 library preparation kit on the NGS STAR. TruSight Tumor 170 simultaneously analyzes DNA and RNA while covering a wide range of genes and variant types. TruSight Tumor 170 is capable of producing accurate results from low-quality formalin-fixed paraffin-embedded (FFPE) samples with a minimum input requirement of 40 ng. The design of the NGS STAR, as a single configuration, enables implementation of additional methods as well as future Illumina protocols using the TruSight Oncology workflow as they are released.

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