Application
Single-Use Bioprocessing
The single-use bioprocessing industry prioritizes technologies that enhance ease-of-use and minimize contamination risk.
Pre-installed sensor elements in a single-use container that are sterilized together are fundamental to this approach, merging the reliability of traditional sensors with the convenience of disposable systems.
This allows equipment for bioprocessing to be ready-to-use with pre-calibrated sensor systems, enabling full automation.
Single-Use Bioprocessing Applications
Accurate, single-use sensors support continuous monitoring across every stage of your bioprocessing workflow. From media preparation, mixing, and intermediate storage, to cell culture and fermentation, where pH and dissolved oxygen (DO) are vital.
These pre-installed, ready-to-use sensors increase process efficiency and support consistent yield across runs. These reliable solutions seamlessly integrate into various containers, including single-use bags and rigid bioreactors, extending to downstream applications and flow cells for comprehensive process control.
For further control, sensors for viable cell density (VCD) and conductivity can be implemented.
How Hamilton Supports Your Single-Use Bioprocessing Workflows
Hamilton pre-calibrated, gamma-sterilized single-use sensors offer easy integration into single-use bags/bioreactors and existing controllers, with many featuring Arc Intelligent technology for improved data management and accurate bioprocess monitoring, helping you streamline setup, improve data accuracy, and ensure process reliability.
Conductivity (Conducell-P SU, Arc Module Cond-P SU), pH (OneFerm SU), and DO (VisiFerm SU) sensors monitor media and buffer preparation. Incyte SU VCD sensors can be used for early cell seeding/expansion.
Reliable pH (OneFerm SU) and DO (VisiFerm SU) monitoring is crucial. Incyte SU VCD sensors provide real-time cell density data directly in bioreactor bags.
Continuous VCD monitoring with Incyte SU sensors determines optimal harvest time. DO and pH can also be monitored.
Conductivity (Arc Module Cond-P SU patch), pH (OneFerm SU), and DO (VisiFerm SU) sensors ensure accurate monitoring during downstream steps.
Conductivity (Arc Module Cond-P SU patch) and pH (OneFerm SU) ensure consistent media and buffer quality.
Explore Our Single-Use Bioprocessing Solutions and Applications in Detail
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Sensors for Single-Use
Incyte-P SU
Hamilton’s Incyte SU sensor elements are pre-installed as an integral part of a single-use container with a long shelf life. They provide accurate, stable measurements and come ready-to-use and pre-calibrated. They connect to the Arc Module Incyte SU for reliable measurement in single-use applications. Our SU VCD sensors combine the reliability and measurement stability of conventional sensors with the ease of use as an integral part of the bioreactor.
Collect real-time viable cell density measurements for deeper insights and data-driven process optimization.
Arc Module and VisiFerm SU
VisiFerm SU RS485-ECS
The VisiFerm SU RS485-ECS is designed for reliable dissolved oxygen (DO) measurement in single-use applications with the ODO Cap Sx sensor element.
Good to Know About Single-Use Bioprocessing
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Solutions for the Top 3 Challenges of Single-Use Bioprocessing
Challenge: Slow and complex traditional setups due to calibration and sterilization strips.
Solution: Hamilton single-use sensors are pre-calibrated, sterilized and ready for direct integration, enabling a simple and quick integration and setup.
Challenge: Contamination and equipment malfunction.
Solution: Reusable systems struggle with a high risk of contamination and equipment failure due to repeated use and complex cleaning protocols. Hamilton integrated single-use systems are not only more hygienic and minimize contamination, including particulates, but are also very cost-effective. For example, the Hamilton OneFerm pH is available as a reliable glass tech in a single-use format.
Challenge: Difficult, costly integration of new sensors with existing systems.
Solution: Hamilton sensor’s wide-range connectivity ensures seamless compatibility with existing bioreactors/controllers/containers. Hamilton sensors offer flexible connection options (Modbus and 4–20mA) via Arc Intelligent Technology, providing seamless integration into existing bioreactor and control systems.
What Is Single-Use Bioprocessing?
Single-use bioprocessing has become an industry standard for biopharmaceutical manufacturers, with single-use bioreactors featuring integrated sensors taking a central role in prioritizing sterility and efficiency. These innovative systems combine disposable bioreactor bags with pre-calibrated and pre-sterilized sensors, enabling real-time monitoring of critical parameters such as pH, dissolved oxygen, and viable cell density.
A key advantage of this approach is the elimination of traditional cleaning and sterilization procedures, which significantly reduces contamination risks and setup time. The integrated sensors deliver real-time data, giving you greater control, faster decision-making, and increased flexibility across your process. Furthermore, the use of pre-calibrated and sterilized components can simplify validation procedures.
These single-use bioprocessing technologies find broad application within the biopharma industry, including the manufacturing of monoclonal antibodies, vaccines, cell and gene therapies, and other recombinant proteins. While acknowledging existing challenges like sensor reliability and waste management, single-use bioreactors offer a streamlined and efficient platform, particularly beneficial for cell culture applications, propelling the biopharma industry towards more agile and contamination-free bioprocessing.
Hamilton offers a full portfolio of single-use sensors, such as OneFerm pH, VisiFerm SU for dissolved oxygen, Incyte SU for viable cell density, and Conducell-P SU with the Arc Module Cond-P SU for conductivity, specifically designed to meet the needs of biopharmaceutical manufacturers utilizing single-use bioprocessing.
Other Single-Use Bioprocessing Resources
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
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