ADME Tox in pharmacokinetics and pharmacology represents absorption, distribution, metabolism, excretion and toxicology. It describes the disposition of a pharmaceutical compound within an organism. These criteria are used in drug discovery to investigate the drug levels and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug.
ADME Tox covers a lot of different assays investigating parameters such as membrane permeability in e.g. PAMPA and Caco-2 assays or metabolic stability and toxicity using e.g. Cytochrome P 450, microsome or hepatocyte assays. Hamilton has experience in designing and realization of such projects, both on relative small scale level using a single STARlet instrument for one specific assay to big systems combining several STARs with third party devices and a variety of parallel protocols.