Automated Extraction of Ultra High Molecular Weight (UHMW) DNA for Bionano Optical Genome Mapping on the Hamilton Long String STAR V

NGS methods are well established for detecting most sequence variants. However, these approaches are unable to accurately resolve complicated repetitive or high GC content regions of the genome. This makes the detection of structural variants especially challenging. With Bionano Optical Genome Mapping (OGM), structural variants can be detected in an unbiased, genome-wide fashion at high sensitivity. This revolutionary technology sheds light on previous “blind spots” for conventional sequencing and cytogenetic assays; however, it requires isolation of UHMW DNA. These molecules, typically ranging between 250 kbp up to > 1 Mbp in length, are more difficult to obtain, as compared to conventional isolation procedures.

Hamilton now provides the world’s first automated solution for Ultra High Molecular Weight (UHMW) DNA extraction on the Long String
STAR V. With this highly efficient and time-saving sample processing solution, Optical Genome Mapping (OGM) can be achieved at higher scale.

Future-proof
Scalable preparation of UHMW DNA for Bionano OGM for increased number of samples

Superior DNA
Optimal magnetic disk handling through Hamilton MagRod technology avoids DNA sheering

Gain hands-off time
Automated walk-away workflow with instrumentation for reduced hands-on time

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