PRP-C18 Columns

High efficiency separations at any pH
The Hamilton PRP-C18 is a new HPLC column designed to provide high-efficiency, reversed-phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability (> 100°C), does not shrink or swell, and is completely inert to most conditions commonly encountered in reversed-phase chromatography.
The PRP-C18 is a durable and effective column for general purpose HPLC and especially well-suited for specialized applications in the clinical, pharmaceutical, environmental, food, forensics, and life sciences industries.

Oligonucleotide Purification
The properties of the PRP-C18 make it a superior column in the field of oligonucleotide purifications, providing:
- Superior resolution for purer oligos
- Extended column lifetime for increased productivity
- High loading capacity for time and cost savings
PRP-C18 Organic applications:
- small molecules (< 2,000 mw)
- pharmaceuticals
- steroids
- halides
- vitamins
- amino acid analysis
- herbicides
Examples of analytes:
- Peptides
- DNA
- RNA
- Oligonucleotides
- Vitamins
- Steroids
- Herbicides
- Pharmaceutical compounds
Resources
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PRP-C18 Product Datasheet
Explore the benefits of the PRP-C18 HPLC Column.
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USP "L" Column Listings
Explore Hamilton’s qualifying USP “L” columns. -
Choosing Column Specifications
The sample amount needed to be purified or separated for analysis will dictate which scale of chromatography is needed. In general, the scales of chromatography are microbore, analytical, semi-preparative, and preparative. Nanoscale and microscale are smaller scale ranges but are not covered in Hamilton’s product offerings. READ MORE

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