Hamilton [MPE]²
One Device Meets Your Solid-Phase Extraction Needs
Hamilton’s Monitored Multi-Flow Positive Pressure Evaporative Extraction module, or [MPE]2™, is an all-in-one automated solid-phase extraction (SPE) device. Compact, versatile, and affordable, [MPE]2 is perfect for applications requiring positive pressure extraction, evaporation, or reagent dispensing.
Dual Elevator Design for Positive Pressure Applications
Hamilton’s patented dual elevator design delivers high-throughput capabilities and consistent results.

Innovative Modules for Evaporation and Reagent Dispensing
The [MPE]2’s add-on modules provide customized solutions for a wide range of applications.
THE EVAPORATION MODULE
- Provides sorbent drying
- Variants for different plate formats
THE REAGENT MODULE
- Dispensing for up to 17 different reagents
- 1 mL dispensing across a 96-well microplate in less than one minute

Labware Flexibility
[MPE]2 offers flexibility for labs running multiple applications. The platform is compatible with 24, 48, and 96 well plates as well as a variety of SPE cartridges.
Hamilton is Making
Strides in Plasmid
Read “High-Throughput Plasmid DNA Purification Using the [MPE]2 Positive Pressure Module”
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Specific Applications
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Analysis of 47 Pesticides in Cannabis for High-Throughput Analysis: Traditional dSPE vs. Positive Pressure dSPE in a 96-Well Plate
This study examines using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction approach coupled with either traditional dispersive-Solid Phase Extraction (dSPE) clean up versus UCT’s dSPE clean up in 96-well plate format using Hamilton’s [MPE]2 — automated positive pressure extraction and evaporation module — for the analysis of 47 pesticides in marijuana. This analysis demonstrates that for most compounds investigated, the high-throughput cleanup method exhibits comparable results to traditional dSPE cleanup. -
High-Throughput Filtration Using the [MPE]2 for Cannabinoid Analysis
In this study, an automated high-throughput filtration method, using the Hamilton [MPE]² — Monitored Multi-flow, Positive Pressure Evaporative Extraction module — from Hamilton Robotics, was evaluated for cannabinoid analysis in multiple matrices. -
High-Throughput Plasmid DNA Purification Using the [MPE]2 Positive Pressure Module
In this case study, we demonstrate that the combination of [MPE]2 and MACHEREY-NAGEL's NucleoSpin® 96 Plasmid Kit provides an automated and high-throughput plasmid DNA purification solution with reliable performance and excellent yields.