The Hamilton NIMBUS Presto Offers Automated and Optimized Magnetic Bead-Based Extraction
Hamilton, together with Thermo Fisher Scientific, optimized the NIMBUS Presto assay ready workstation for fully automated and parallel nucleic acid and protein extraction of a variety of biological samples. Blood, plasma, tissue, saliva, FFPE and buccal swabs may be automatically processed on a single, integrated system with a small footprint to conserve precious laboratory space. The workstation is integrated with the Thermo Fisher Scientific KingFisher Presto and pre-programmed for use with proven KingFisher magnetic bead-based sample processing. Two interchangeable magnetic heads allow parallel processing in 24- and 96-well plate formats.
Convenient, Individualized Flexibility
Hands-Free, Hassle Free Operation
Precise, Repeatable Liquid Handling and Plate Transport
|53.6 in (1359 mm)
|28. in (709 mm)
|35.0 in (889 mm)
Automated Isolation of High Molecular Weight (HMW) DNA from Human Blood Samples with PacBio® Nanobind® Technology on the Hamilton NIMBUS® Presto - Next Level Preparation of Extracts for Long-Read SequencingLong-read sequencing technology provides great potential in several clinically relevant areas of human genomics. Recent advancements allowing increased sequencing throughput and accuracy at a more affordable cost have already been made. However, the applied workflows still contain bottlenecks, especially in the extraction process steps that increase variability in HMW DNA (50 kbp -250 kbp) yield and quality, while hindering the processing of higher sample numbers. Overcoming these hurdles by robust high-throughput, automated solutions will support the growing number of large-scale population genomics studies and clinical research applications.
Automated extraction of High Molecular Weight (HMW) DNA with PacBio® Nanobind® technology on the Hamilton NIMBUS® Presto Assay Ready WorkstationRapidly emerging long-read sequencing technologies, including PacBio Single Molecule, Real-Time (SMRT®) sequencing, provide substantial advantages for (de novo) genome assembly, detecting structural variants, and higher accuracy in repetitive or high GC content regions. A key requirement for long-read, third-generation sequencing approaches is the extraction of HMW DNA (50 kb – 250 kb). As the field matures and sample numbers increase, robust, high-throughput sample preparation methods are needed to support large-scale studies in pan-genomics and clinical research applications.
Whole Genome and Transcriptome Analysis for Leukemia DiagnosticsThe rationale behind the automation of the assay is mainly in terms of a quality improvement and enhancement of productivity, provided by minimizing the bias that might be otherwise introduced by manual library preparation. Moreover, the automated system is sufficiently flexible to adapt and therefore easily meet evolving needs
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