Hamilton STARlet automated liquid handler open lid showing deck with labware, in a laboratory setting

NGS STARlet

Low-Mid Throughput
24
Samples Per Run
Space-Saving
Value Class
Compact Footprint
Ideally Suited for
High Priority Samples
Or Small Batches

Easy Transition from Manual NGS Library Prep

Intuitive software with optimized methods, along with hands-free processing, significantly reduces user time and variability risks compared to manual methods.

Scientific Citations

NGS Automation for Any Laboratory

The NGS STARlet saves time and lab space when performing NGS library preparation protocols for small sample batches or high-priority samples—up to 24 samples at once. The NGS STARlet is based on our trusted Microlab STARlet automated liquid handler, featuring CO-RE II Technology in the eight independent CO-RE pipetting channels for the ultimate liquid handling precision and accuracy. Everything is controlled and operated via the latest VENUS software. This small but mighty automated NGS library prep solution may be connected to a laboratory information management system (LIMS) to further enhance efficiency and reproducibility.

Use Your Preferred NGS Chemistry Kit

A standardized NGS framework supports diverse NGS library preparation protocols and kit providers.  Pre-established methods, combined with standardized hardware and software, accelerate your path to consistent NGS workflows

NGS Library Prep for Clinical Laboratories

Hamilton offers the Clinical NGS STARlet for laboratories seeking an IVDR-certified solution.

Common applications Genomics, NGS Library Prep, Long-String Genomics, Pharma & Biopharma, Drug Discovery

Featured Technologies

Hamilton Technology Starts at the Channel.

Pipetting Technology

  • DPS - Dynamic Positioning System

    For Efficient Movements

    DPS enables all channels to pipette simultaneously, even across non-uniform patterns. Unlike fixed channels with equidistant spreading, DPS offers efficient yet flexible liquid handling for cherry picking, non-uniform and variable volume samples, and complex pipetting workflows.

    Automated liquid handling system dispensing blue fluid into a row of glass test tubes via multi-channel pipette heads

  • CO-RE II Tip/Tool Attachment

    The Key to Liquid Handling Workflow Excellence

    The new CO-RE II technology assures more precise tip alignment, minimizing the risk of collisions. Also, tip coupling is faster which boosts productivity. Besides tips, a wide range of Hamilton tools are applicable with CO-RE II.

    Cross-section diagram and 3D render of CO-RE II tip and stop disk, highlighting metal coupler and sealing surface (red o-ring).

  • Aerosol-Free Tip Ejection

    To Prevent Cross-Contamination

    As part of CO-RE II technology’s functionality, pipette tips are gently ejected from each automated liquid handler pipetting channel. This prevents aerosol generation that may expose users to harmful biohazards or cross-contaminate samples and laboratory surfaces.

    Multi-channel pipette head with disposable tips positioned over a rack of sample tubes on an automated liquid handling platform
  • Liquid Handling Technology
    MAD - Monitored Air Displacement

    For Unmatched Reliability

    MAD monitors the air displacement in each pipetting channel of a Hamilton automated liquid handler. During liquid aspiration steps, this non-contact technology immediately identifies clots, empty wells, or other aspiration issues. It also delivers a confirmation of successful aspiration in each pipetting channel of a Hamilton automated liquid handler.

  • Liquid Handling Technology
    Dual Liquid Level Detection (LLD)

    For Accurate Aspirations

    Dual LLD uses two sensors on each liquid handling pipetting channel. A capacitance sensor detects aqueous and conductive liquid surfaces while a pressure-based sensor works with non-conductive, viscous, and volatile liquids. Together, they ensure highly accurate and reliable liquid handling performance.

  • Liquid Handling Technology
    TADM – Total Aspiration & Dispense Monitoring

    For Real-Time Pipetting Accuracy

    During aspirate and dispense steps, TADM monitors real-time pressure changes in each Hamilton liquid handler pipetting channel. Results are compared against expected values to expose anomalies like bubbles and insufficient volumes. Sample transfers are verified with a digital audit trail.

  • Liquid Handling Technology
    Anti-Droplet Control (ADC)

    For Drip-Free Pipetting

    Pressure sensors on Hamilton’s pipetting channels continuously detect variations. Any changes are immediately compensated for by dosing drive movements to prevent droplet formation. Essential for high-precision and accuracy when pipetting volatile liquids like ethanol and acetonitrile.

  • Liquid Handling Technology
    LFC - Liquid Fractionation Control

    For Detecting Liquid Layers via Pressure Monitoring

    Pressure-based monitoring method to detect liquid interfaces in layered samples like centrifuged blood or liquid-liquid chemical extractions. LFC simultaneously and rapidly identifies, separates, and aliquots up to 16 samples into various labware targets. It includes full sample traceability.

  • Accessories
    Autoload

    For Convenient Identification

    Uses a 1D barcode scanner to automatically identify and verify samples, carriers, and consumables such as tips, tubes, micro plates, and reagent troughs as they are placed onto the liquid handling deck. Optional 2D barcode reading is available, and results may be sent to any LIMS for documentation.

  • Transport Solutions
    CO-RE Gripper

    For Additional Movements

    Further streamline automated workflows with CO-RE Grippers. These agile grippers transform Hamilton's precision pipette channels into on-deck labware transport solutions on Hamilton automated liquid handlers.

Minimize manual variability and errors in NGS library preparation with highly repeatable, reproducible automated workflows.

With efficient, hands-free NGS library preparation, users can focus on higher-order tasks instead of manually pipetting.

Easily adjust to different sample batch sizes and schedule with flexible workflow choices at any time.

Easily trace and document automated NGS library preparation steps with barcode scanning and performance monitoring tools.

  • Hamilton automated liquid handler deck view with labeled on-deck thermal cycler module highlighted in green
  • Hamilton automated liquid handler deck showing labeled consumable and reagent storage positions, including tip racks, plates, and tube carriers
  • Hamilton automated liquid handler deck with position 3 highlighted, showing plate carriers and labware positions.
  • Hamilton automated liquid handler deck with green-highlighted column showing four labeled labware positions for temperature incubation and mixing
  • Top-down view of a Hamilton automated liquid handling workdeck with labeled component 5, a transportation tool highlighted in green near the lower-right deck area.
  • Hamilton automated liquid handler deck viewed from above, with item 6 highlighted: a barcode scanner module in the lower-right area.

Explore the NGS STARlet

The space-efficient NGS STARlet is fully equipped for full walk-away automated NGS library preparation.

1

On-Deck Thermal Cycler (ODTC), Optional

Highly reproducible thermal cycling in most 96-well PCR plates thanks to uniform heating, rapid ramp rates, adjustable heating and cooling rates, and the Hamilton PCR ComfortLid.
2

Consumables and Reagent Storage

CO-RE II tips, plates, and reagent reservoirs are easily accommodated on the open deck, while barcode verification confirms correct positioning.
3

Processing Positions

To streamline NGS workflows, a primary pipetting zone processes MIDI and PCR plates. It also includes a magnet plate for rapid bead-based cleanup steps.
4

Temperature and Mixing

Integrated modules include two Hamilton Heater Shakers (HHS) with 2500 rpm speed, and up to 105 ºC heating, along with two heating/cooling devices (CPACs).
5

Transportation Tool

Using the CO-RE Gripper, plates are reliably and precisely transported to and from any NGS STARlet deck position without user intervention.
6

Automated Loading and Scanning

Track samples and reagents, and verify correct consumable loading using the autoload function and barcode scanning.

NGS STARlet Specifications

NGS STARlet Specifications

Print

System Dimensions

Height
90.3 cm (2 ft, 11.55 in)
Width
1.12 m (3 ft, 8.25 in)
Depth
79.5 cm (2 ft, 7.3 in)

Transport Tools

CO-RE Gripper
Standard
Internal Swivel Arm Plate Handler (iSWAP)
Optional

Platform/Accessories

Capacity (ANSI/SLAS Positions)
25
Device Integration
180° (Left and Right)

Sample Loading and Tracking Options

Sample Loading
Manual
Manual Load
Standard
Autoload Barcode Scanner (1D)
Optional
Autoload Barcode Scanner (2D)
Optional

Pipetting Options

1 mL Channels
4
8
Multi-Probe Head Option
96
Pipetting Range 1
1 µL - 1000 µL

1 Depending on Configuration

NGS STARlet Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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NGS STARlet Product Line TIMG

Flyer

NGS STARlet Product Line | Flyer

Meet the NGS STARlet product line, designed for efficient and traceable NGS library preparation in labs with limited space or lower sample volumes.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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Installation & Beyond

Trust in Hamilton’s Field Service Engineers for high-quality automated liquid handler installation, preventative maintenance, and field repairs.

Backed by world-class service and support.

For over 75 years, the Hamilton name has been recognized globally for its unwavering commitment to quality. That pledge extends to creating long-term customer partnerships. We're proud to offer in-depth training courses, on-site field support, custom product builds, and so much more.

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