Hamilton STAR V automated liquid handler with open front panel, showing pipetting deck with labware in a lab
High Throughput
96
Samples Per Run
Enhanced Capacity
Professional Class
Efficient Deck Layout
Ideally Suited for
Demanding or Large-Batch
Protocol Processing

No Barriers to Productivity

With spacious consumable storage, optimized devices, wide chemistry compatibility, and more, the NGS STAR V streamlines and scales NGS sample throughput.

NGS Automation for High-Throughput Laboratories

The NGS STAR V meets the demands of high-throughput NGS library preparation, efficiently processing large 96-sample sample batches and complex workflows with high speed, precision, and accuracy. The system is built upon our well-known Microlab STAR V automated liquid handler. Precise and accurate liquid handling is driven by CO-RE II Technology, used in the eight independent pipetting channels and the CO-RE 96-Probe Head, used for aspirating and dispensing into 96 wells simultaneously. Everything is controlled through the latest VENUS software.

Connect the NGS STAR V to a laboratory information management system (LIMS) to enhance walkaway automation and centralize control.

Any NGS Kit. Any Chemistry Vendor.

A wide range of optimized, qualified methods from leading industry partners empower time-efficient workflows. Together with hardware and software standardization, these methods help you to save time and sustain peak production efficiency. Expert Hamilton support along the way adds to the reliability you can expect.

Common applications Genomics, NGS Library Prep, Long-String Genomics, Pharma & Biopharma, Drug Discovery

Featured Technologies
  • Pipetting Technology
    DPS - Dynamic Positioning System

    For Efficient Movements

    DPS enables all channels to pipette simultaneously, even across non-uniform patterns. Unlike fixed channels with equidistant spreading, DPS offers efficient yet flexible liquid handling for cherry picking, non-uniform and variable volume samples, and complex pipetting workflows.

  • Pipetting Technology
    CO-RE II Tip/Tool Attachment

    The Key to Liquid Handling Workflow Excellence

    The new CO-RE II technology assures more precise tip alignment, minimizing the risk of collisions. Also, tip coupling is faster which boosts productivity. Besides tips, a wide range of Hamilton tools are applicable with CO-RE II.

  • Pipetting Technology
    Aerosol-Free Tip Ejection

    To Prevent Cross-Contamination

    As part of CO-RE II technology’s functionality, pipette tips are gently ejected from each automated liquid handler pipetting channel. This prevents aerosol generation that may expose users to harmful biohazards or cross-contaminate samples and laboratory surfaces.

  • Liquid Handling Technology
    MAD - Monitored Air Displacement

    For Unmatched Reliability

    MAD monitors the air displacement in each pipetting channel of a Hamilton automated liquid handler. During liquid aspiration steps, this non-contact technology immediately identifies clots, empty wells, or other aspiration issues. It also delivers a confirmation of successful aspiration in each pipetting channel of a Hamilton automated liquid handler.

  • Liquid Handling Technology
    Dual Liquid Level Detection (LLD)

    For Accurate Aspirations

    Dual LLD uses two sensors on each liquid handling pipetting channel. A capacitance sensor detects aqueous and conductive liquid surfaces while a pressure-based sensor works with non-conductive, viscous, and volatile liquids. Together, they ensure highly accurate and reliable liquid handling performance.

  • Liquid Handling Technology
    TADM – Total Aspiration & Dispense Monitoring

    For Real-Time Pipetting Accuracy

    During aspirate and dispense steps, TADM monitors real-time pressure changes in each Hamilton liquid handler pipetting channel. Results are compared against expected values to expose anomalies like bubbles and insufficient volumes. Sample transfers are verified with a digital audit trail.

  • Liquid Handling Technology
    Anti-Droplet Control (ADC)

    For Drip-Free Pipetting

    Pressure sensors on Hamilton’s pipetting channels continuously detect variations. Any changes are immediately compensated for by dosing drive movements to prevent droplet formation. Essential for high-precision and accuracy when pipetting volatile liquids like ethanol and acetonitrile.

  • Liquid Handling Technology
    LFC - Liquid Fractionation Control

    For Detecting Liquid Layers via Pressure Monitoring

    Pressure-based monitoring method to detect liquid interfaces in layered samples like centrifuged blood or liquid-liquid chemical extractions. LFC simultaneously and rapidly identifies, separates, and aliquots up to 16 samples into various labware targets. It includes full sample traceability.

  • Accessories
    Autoload

    For Convenient Identification

    Uses a 1D barcode scanner to automatically identify and verify samples, carriers, and consumables such as tips, tubes, micro plates, and reagent troughs as they are placed onto the liquid handling deck. Optional 2D barcode reading is available, and results may be sent to any LIMS for documentation.

  • Transport Solutions
    Plate Gripper

    For Flexible Integration

    Plate Grippers move labware to-and-from any position on the Hamilton automated liquid handling deck. For even greater hands-free efficiency and workflow integration, the Plate Grippers can transport plates to-and-from nearby off-deck devices (access location is platform-specific).

With an expansive deck layout, featuring optimized temperature control,  you can keep pace with demand and technological advancementsevolutions.

Reduce the risk of time-consuming and costly sample reprocessing with highly precise, accurate, and consistent operation.

Rapidly pivot to different sample batch sizes, schedule with flexible workflow choices, and scale from small pilot to larger studies.

Maintain full oversight in high-throughput workflows through integrated barcode checks and real-time performance monitoring.

  • Top-down view of an open Hamilton automated liquid handling instrument deck with labeled modules and a green highlight box
  • Hamilton automated liquid handler deck with labeled consumable and reagent storage zones highlighted in green
  • Top view of a Hamilton automated liquid handler deck with labeled processing positions highlighted in green
  • Top view of a Hamilton automated liquid handling deck with green-outlined modules for temperature control and mixing
  • Top-down view of an open Hamilton automated liquid handling workdeck loaded with labware plates and modules
  • Hamilton automated liquid handler with autoload deck, top-down view showing pipette carrier rail, labware positions, and sample storage modules

Explore the NGS STAR V

The NGS STAR V boasts an expanded deck layout, integrating all essential equipment for full walk-away NGS library preparation, ensuring high throughput, scalability, and accelerated workflow efficiency

1

On-Deck Thermal Cycler (ODTC), Optional

Use with the PCR ComfortLid to automate PCR cycling processes with high temperature uniformity and accuracy. Accessible with the eight independent CO-RE channels.
2

Consumables and Reagent Storage

Store CO-RE II tips, plates, and reagent reservoirs on the standardized deck to reduce restocking interruptions. Add large reservoirs for use with the CO-RE 96 Probe Head.
3

Processing Positions

Supports pipetting into MIDI and PCR plates and includes a dedicated magnet plate to facilitate automated bead-based cleanup steps.
4

Temperature incubation and mixing

Active modules include two Cold Plate Air Cooled Heater/Coolers (CPACs) with temperature ranges of 4–110 ºC, a Hamilton Sample Cooling Carrier, and a Thermoshaker.
5

Transportation Tool

Integrated IPG (Internal Plate Gripper) and QCG (Quad CO-RE® Gripper) facilitate stable and precise plate transport steps from and to any deck position.
6

Automated Loading and Scanning

Autoload function with barcode scanning automatically identifies and verifies samples, consumables, and reagents to prevent errors and sustain full traceability.

NGS STAR V Specifications

NGS STAR V Specifications

Print

System Dimensions

Height
96 cm (3 ft, 1.8 in)
Width
2 m (6 ft, 6.74 in)
Depth
98 cm (3 ft, 2.58 in)
Hamilton STAR V automated liquid handler with NGS branding, closed, front view

Transport Tools

CO-RE Gripper
Standard
Internal Plate Gripper (IPG)
Optional

Platform/Accessories

Capacity (ANSI/SLAS Positions)
60

Sample Loading and Tracking Options

Sample Loading
Automatic
Autoload Barcode Scanner (1D)
Standard

Pipetting Options

1 mL Channels
8
Pipetting Range 1
1 µL - 1000 µL

1 Depending on Configuration

NGS STAR V Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

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Services

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