Application
Dilutions and Dispensing
Precise dilutions and accurate dispensing are essential for reproducible results in pharmaceutical, chemical, and clinical laboratories. From maintaining exact ratios to preparing complex serial dilutions, consistent, reliable operation preserves the quality and reliability of every sample. Precision technologies and (semi)-automation minimize variability, reduce manual effort, and help teams achieve high-throughput screening and sample preparation without compromising quality or consistency.
Advanced dispensing requires more than speed. It depends on precision, control, and reliability to maintain consistent concentrations. Whether preparing reagents, serial dilutions, or cleaning solutions, Systems with integrated monitoring deliver reproducible results and improved efficiency. In pharmaceutical and chemical development, these solutions streamline workflows, safeguard data integrity, and support the evolving needs of modern research and production.
How Hamilton Supports your Dilution and Dispensing Workflows
Hamilton supports dilution and dispensing workflows across every level of automation, from manual to fully integrated systems. For low-throughput or highly controlled manual applications, Hamilton’s precision-engineered syringes or Soft-Grip pipettes ensure accurate volume handling and chemical compatibility. Semi-automated solutions, such as the Microlab Diluter-Dispenser, provide programmable, high-precision dilution and dispensing with minimal hands-on time, making them ideal for clinical and quality control labs.
For labs that need scalable, high-throughput liquid handling, Hamilton offers a range of fully automated solutions. These include syringe drives, such as the PSD/4 and PSD/6, as well as liquid handling platforms, including the Microlab Prep, Microlab Nimbus, Microlab STAR, Microlab STAR V, Microlab VANTAGE, and BioSpot. Together, these systems provide precise control over dilution ratios, volume transfers, and workflow integration.
With tools like DeckWatch for real-time monitoring and seamless Laboratory Information Management System (LIMS) integration, you can ensure reproducible results, data integrity, and run efficient workflows in drug discovery, chemical formulation, and diagnostic testing.
Explore our Dilutions and Dispensing Solutions and Applications in Detail
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Lab Syringes
Gastight Syringes
The solution for dispensing both gases and heterogeneous liquids. Hamilton Gastight syringes are equipped with a precision-machined PTFE plunger tip to create a leak-free seal.
Lab Syringes
Microliter Syringes
Hamilton Microliter syringes are ideal for dispensing homogeneous liquid samples not prone to glass bonding or precipitation. With a hand-fitted stainless steel plunger for frictionless movement and minimal wear, these syringes are designed to last.
Life Science Syringes
Neuros Syringes
Hamilton Neuros syringes are designed for to accomodate the unique needs of neuroscience injections into rats and mice.
Pipettes & Universal Pipette Tips
Single-Channel Adjustable Volume Pipettes
Hamilton's adjustable volume pipettes provide precise, reliable liquid handling with ergonomic design and easy calibration.
Pipettes & Universal Pipette Tips
Single-Channel Fixed Volume Pipettes
Hamilton's fixed volume pipettes provide precise, reliable liquid handling with ergonomic design and easy calibration.
Pipettes & Universal Pipette Tips
Multi-Channel Pipettes
Hamilton's multi-channel pipettes provide efficient and precise liquid handling with ergonomic design and easy calibration.
Benchtop & Handheld Solutions
Diluter Dispensers
Semi-automated liquid handling, dilutions, and reagent dispensing.
Diluter Dispensers
Microlab 600 Diluters
Quickly perform accurate and repeatable dilutions independent of viscosity, vapor pressure, or temperature.
Diluter Dispensers
Microlab 600 Dispensers
Dispense a single solution or two solutions independently. Pipette, serial dispense, titrate, or aliquot with confidence.
The Hamilton Microlab Prep is an affordable liquid handler perfect for automating workflows. This entry-level liquid handler supports automated PCR setup and serial dilution.
Hamilton STAR V, a cutting-edge liquid handling robot, unites Microlab STAR flexibility with Microlab VANTAGE high-performance capabilities to boost efficiency. The Microlab STAR V offers speed, precision, and technology for automated liquid handling. Upgrade your lab—explore the Microlab STAR V!
Hamilton Microlab NIMBUS is a compact liquid handler that uses air displacement pipetting to achieve superior measurement accuracy. With Microlab NIMBUS, experience fast, easy to use, and superior quality pipetting in a compact system at an affordable price.
The Hamilton Microlab STAR is a reliable and versatile automated liquid handling platform. With advanced features like multi-probe heads, pipetting technologies, and VENUS software, this premier liquid handling system fits your laboratory needs. Revolutionize your workflows with the STAR today!
Hamilton VANTAGE 2.0 is a cutting-edge liquid handling system with automated precision. Optimize workflows with the VANTAGE robot, all while boosting performance, safeguarding samples, and maximizing walk-away time. Discover the Hamilton VANTAGE liquid handler for your current & future needs.
Automated workstation
BIOSPOT® Workstation
Specializes in microplate applications, achieving unparalleled accuracy in dispensing nanoliter volumes or compound screening and assay miniaturization.
Programmable Syringe Pumps
PSD/4 Precision Syringe Pumps
The PSD/4 syringe pump is a popular choice for customers looking for a high-precision syringe pump. It only uses a small footprint and comes at an economical price. This half-height (30 mm syringe) pump is available with a variety of different motor and gearing options.
Programmable Syringe Pumps
PSD/6 Precision Syringe Pumps
The PSD/6 syringe pump is the full-height (syringes up to 60 mm) version of a PSD/4. The additional syringe length increases pumping capacity. It can have up to 384,000 steps of resolution while maintaining high accuracy and precision.
Manual GC and HPLC Syringes
HPLC Manual Injection
Hamilton provides a variety of custom needle syringes that are designed for use with manual HPLC injection ports. The manufacturing process and quality assurance procedures ensure that every syringe we sell will provide superior accuracy and precision.
Syringes for HPLC Autosamplers
Syringes for Agilent HPLC Autosamplers
Hamilton offers a variety of syringe options for the Agilent 1290 Infinity LC Injector, ProStar 410 HPLC Autosampler and 1090 HPLC Autosampler.
Syringes for HPLC Autosamplers
CTC/LEAP PAL HPLC Autosampler Syringes
Hamilton offers 15 quality syringe options, C-Line and X-Type, for the CTC/Leap LC/HTC/HTS PAL, and 2 quality syringe options for the CTC/Leap A200S HPLC Autosampler.
Syringes for HPLC Autosamplers
Syringes for Antec HPLC Autosamplers
Hamitlon syringes are available for Antec Auto Samplers. Featuring a polytetrafluoroethylene (PTFE) plunger tip for Gastight applications with strictly machined tolerances for reproducible results from injection-to-injection and Hamilton glass barrel surface finish for superior syringe life.
Syringes for HPLC Autosamplers
Syringes for Spectra Physics ThermoFinnigan HPLC Autosamplers
Hamilton offers two quality syringe options for the ThermoFinnigan SP8780, SP8875, and SP8880, and four quality syringe options for the AS100, AS300, AS1000, AS3000, and AS3500 HPLC Autosamplers.
Syringes for HPLC Autosamplers
Syringes for Waters HPLC Autosamplers
Hamilton offers syringes for the Waters 2777, Waters 2707 and Waters WISP HPLC Autosamplers.
Syringes for HPLC Autosamplers
Syringes for Dionex HPLC Autosamplers
Hamilton syringes for Dionex Autosamplers. Featuring a rugged polytetrafluoroethylene (PTFE) plunger tip for Gastight applications strictly machined tolerances for reproducible results from injection-to-injection and Hamilton glass barrel surface finish for superior syringe life.
Syringes for HPLC Autosamplers
Syringes for Hitachi HPLC Autosamplers
The LaChrom Elite Autosampler represents a new standard of performance in HPLC. Whether you need high sample capacity, extreme precision, ultra-low carry over or rapid cycle times between injections, the LaChrom Elite models excel.
Syringes for HPLC Autosamplers
Syringes for Spark Holland HPLC Autosamplers
The world-famous Hamilton syringe is now available for your Spark Holland Autosampler! Featuring a rugged polytetrafluoroethylene (PTFE) plunger tip for highly reproducible results from injection-to-injection and Hamilton glass barrel surface finish for superior syringe life. These syringes fit the Midas, Triathlon, Endurance and Alias model autosamplers.
Syringes for HPLC Autosamplers
Syringes for Shimadzu HPLC Autosamplers
Hamilton offers one quality syringe option for the Shimadzu SIL-6A, and two quality syringe options for the SIL-10AF/SIL-10AP HPLC Autosampler.
Syringes for HPLC Autosamplers
Syringes for Bruker Varian HPLC Autosamplers
Hamilton syringes are available for your Varian ProStar HPLC Autosampler! Featuring a rugged polytetrafluoroethylene (PTFE) plunger tip for Gastight applications that provides strictly machined tolerances for reproducible results and Hamilton glass barrel surface finish for superior syringe life.
Syringes for HPLC Autosamplers
Syringes for Beckman Coulter HPLC Autosamplers
Hamilton offers a wide variety of syringes specifically designed for Beckman Coulter 508 Autosamplers. Featuring a rugged PTFE plunger tip for Gastight applications with strictly machined tolerances for reproducible results and Hamilton glass barrel surface finish for superior syringe life.
Syringes for HPLC Autosamplers
Syringes for Grace Alltech HPLC Autosamplers
The world-famous Hamilton syringe is now available for your Grace/Alltech Model 580 Autosampler! Featuring a rugged PTFE plunger tip for Gastight applications with strictly machined tolerances for reproducible results and Hamilton glass barrel surface finish for superior syringe life.
Syringes for HPLC Autosamplers
Syringes for Kontron HPLC Autosamplers
Hamilton offers one quality syringe option for the Kontron 360, 460 and 465 HPLC Autosampler.
Syringes for HPLC Autosamplers
Syringes for Perkin Elmer HPLC Autosamplers
Hamilton offers syringe options for the Perkin Elmer Series 225 LC Autosampler, FLEXAR HPLC Autosampler and Series 200 HPLC Autosampler.
Good to Know About Dilution and Dispensing
This section provides a selection of additional resources related to the application described on this page. It includes helpful articles, videos, and blogs that offer deeper insights into the topic.
Hamilton Products in Action
A collection of videos showcasing Hamilton products in use, providing practical insights into their functionality and benefits.
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Solutions for Top 3 Challenges in Diluting and Dispensing
Inconsistent Dilution Ratios in Serial Dilutions
Challenge: Manual preparation of serial dilutions and other dilution workflows can introduce pipetting errors and inconsistencies, especially when dealing with small volumes. These discrepancies can alter the concentration of a solute, undermining data quality and reproducibility in assay results.
Solution: Hamilton’s automated liquid handling systems and semi-automated dilution control units ensure precise volume transfers and maintain consistent dilution ratios throughout the process. With full control, users can eliminate variability and improve reproducibility across assays and high-throughput screening campaigns.
Variability in Chemical Dispensing Across Repetitive Workflows
Challenge: In manual workflows, repetitive chemical dispensing, such as the formulation of cleaning solutions or the distribution of reagents, can lead to operator fatigue, volume drift, and inconsistent dispensing results over time.
Solution: Hamilton platforms offer programmable, high-throughput liquid handling tailored to your dispensing application. These systems enable real-time verification and calibration to maintain consistent performance and deliver instant results, ensuring regulatory compliance and efficient throughput.
Waste of Stock Solutions During High-Volume Dilution Applications
Challenge: Improper system setup or inefficient workflows can lead to excessive use of valuable stock solutions and reagents during dilution applications, increasing cost and environmental impact.
Solution: Hamilton’s intelligent liquid handling platforms minimize dead volume and optimize stock solution use with precise dosing and smart deck layouts. The result is cost-effective, scalable automation with reduced waste, ideal for both R&D and production environments. By automating dilution and dispensing workflows, labs precisely control diluted solution volumes and final concentrations even in high-throughput liquid handling environments. These systems can help scale operations efficiently, reduce waste, and support both research and production-scale environments.
How is Diluting Controlled on a Dispensing Unit?
Diluting can be controlled using manual, semi-automated, or fully automated systems—each suited for different lab needs.
Manual precise dispensing is typically performed using Hamilton syringes or pipettes, offering high precision in low-throughput environments where user control is essential.
Semi-automated systems, such as the Microlab Diluter-Dispenser, streamline dilution tasks with programmable protocols and consistent volume delivery, making them ideal for clinical and Quality Assurance (QA)/ Quality Control (QC) laboratories.
For high-throughput operations, fully automated liquid handling platforms such as the Microlab STAR and VANTAGE feature advanced dilution control systems with real-time monitoring. These systems ensure accurate dilution ratios and reproducibility across serial dilutions, drug discovery, and chemical workflows, significantly reducing manual error and increasing efficiency.
Dilutions and Dispensing Case Studies and Application Notes
Other Dilutions and Dispensing Resoruces
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
Browse app notes, user guides, specification documents, and more in our Knowledge Center.
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