Why should I use the Hamilton Low Retention pipette tips?

Fluid retention is virtually eliminated and Hamilton low retention tips are not siliconized, therefore no sample leaching. You can also expect more reliable results and a reduction in reagent costs of typically 10 - 15%. This is a great benefit especially when working with low volumes of precious samples or with expensive reagents.

Why Should I use CO-RE II Pipette Tips for Low Retention Applications?

In many liquid handling applications, minimizing sample carryover is important to achieve accurate and reproducible results. CO-RE II pipette tips are designed and manufactured to support applications where reduced liquid retention is desired, while remaining suitable for general-purpose automated liquid handling.

What does "low retention" mean in practice?

There is no industry‑wide standard that defines how “low” liquid retention must be for a pipette tip to be classified as low retention. In practice, the term is commonly used to describe pipette tips that perform reliably in applications where liquid adhesion could otherwise affect accuracy or cause sample loss.

CO‑RE II pipette tips are manufactured from carefully selected medical grade polypropylene material and produced under tightly controlled manufacturing conditions. This contributes to smooth internal surfaces and consistent pipetting performance without relying on surface coatings or additive technologies.

How are CO-RE II pipette tips designed to support low retention needs?

CO‑RE II pipette tips achieve their performance through:

Selection of appropriate polypropylene grades
High precision control of the mold and tip surface finish
Strict control of flash, burrs, and overall manufacturing quality

This approach enables CO‑RE II pipette tips to meet the needs of many applications where customers typically request low retention pipette tips—without the use of fluoropolymer or silicone‑based additives that may introduce additional chemical considerations or cost.

When are CO-RE II pipette tips used for low retention applications?

CO‑RE II pipette tips are designed as high‑precision, general‑purpose tips for automated liquid handling and are used across a wide range of applications. Their material selection and controlled manufacturing processes also enable reliable performance in applications where reduced liquid retention may be beneficial.

Importantly, CO‑RE II pipette tips are not limited to low‑retention applications. They are equally suitable for standard aqueous pipetting tasks as well as more demanding workflows involving different liquid properties, volume ranges, and assay formats.

Across past and current customer applications, CO‑RE II pipette tips have been successfully validated under a wide variety of liquid handling conditions.

How should customers select the right CO-RE II pipette tip for their application?

Liquid handling performance depends on multiple factors, including liquid properties, volume range, instrument configuration, and pipetting technique. As with any consumable, customers are encouraged to validate pipette tip performance within their specific application.