• In this case study, we demonstrate use of the Erenna® Immunoassay System with SMC™ Immunoassays integrated onto the Hamilton Microlab STARlet liquid handling workstation in order to create a hands-free, automated, assay-ready workflow.

  • The CAP (Clean Air Protection) system from Hamilton Robotics is an efficient alternative for those who require high throughput sample processing in a clean, positive-pressure environment. CAP is a HEPA-filtered hood that may be integrated with any standard, enclosed Microlab NIMBUS Personal Pipetting Workstation.

  • In this case study, we demonstrate use of the Microlab® STARlet automated liquid handler to automate the processing of up to 96 samples in approximately 90 minutes in the SenSATIVAx workflow, and up to 192 qPCR reactions in approximately 30 minutes in the PathoSEEK workflow, compared to approximately four hours for the same using manual methods.

  • In this case study, we demonstrate that the combination of [MPE]2 and MACHEREY-NAGEL's NucleoSpin® 96 Plasmid Kit provides an automated and high-throughput plasmid DNA purification solution with reliable performance and excellent yields.

  • Here, we demonstrate an automated dSPE sample preparation workflow (see Workflow at end) on the Microlab NIMBUS96 liquid handling workstation. The Microlab NIMBUS96 uses air displacement pipetting for high precision and accuracy when aspirating and dispensing volumes from 1–1,000 μL, while Compressed O-Ring Expansion (CO-RE®) Technology creates an air-tight seal between dSPE tips or other disposable pipetting tips and the pipetting channel mandrels to maximize performance. Cannabinoid levels from nine cannabis plant samples are determined using the automated sample preparation workflow followed by LC-MS/MS analysis. We show that the automated method is rapid and robust while enabling hands-free efficiencies.

  • An improved automated method for the extraction of testosterone in serum was developed using ZnSO4 and Low Porosity Filtration Tips-Ultra Pure (LPFT-UP) on a Microlab® NIMBUS96. The fully automated method incorporates a ZnSO4 solution with acetonitrile on a Hamilton Heater Shaker for improved recovery and precision during protein precipitation. LPFT-UP containing high purity filtration media are used to remove matrix interferences and achieve very low limits of detection. Using this quick (< 2 minutes) and effective, DPX patent-pending, Tip-on-Tip (ToT) technology, the LPFT-UP provide an automated filtration alternative to traditional centrifugation and filtration. This method allows for up to 96 samples to be protein precipitated, filtered, and ready for injection in under 5 minutes.

  • Performing ELISA testing manually opens the possibility for human error and can increase the turnaround time for crucial results, especially considering the current need to process large numbers of antibody testing samples. For this reason, Namida Lab has developed an automated system for high-throughput processing of thousands of serology samples per day to meet the testing demand of employers and large population studies. The system utilizes the Hamilton Microlab® STARplus and integrated devices to fully automate a commercially available anti-SARS-CoV-2 ELISA.

  • The Hereditary Cancer Solution (HCS) by SOPHiA GENETICS is the first capture-based application, which has received the CE-IVD mark. The automation of the HCS by SOPHiA GENETICS protocol is frequently requested in the field, especially in the clinical environment where minimizing human intervention is a plus.

  • Automation of the NGS assay helps to improve and enhance productivity by minimizing bias that might otherwise be introduced when preparing libraries manually. Moreover, the automated system is flexible enough to adapt and therefore easily meet evolving needs.

  • Molecular testing of clinical samples for viral pathogens has already long become standard in both research and diagnostic laboratories. Every molecular biological test relies on high-quality sample material to achieve the best possible sensitivity and specificity. Therefore, the first step of sample analysis – the extraction of viral RNA and DNA – is of the utmost importance for the final result.