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Utilizing Hamilton’s CO-RE disposable tips with DPX technology provides a fast, accurate, and simple extraction method for analyzing drugs of abuse in urine. The Microlab NIMBUS equipped with a CO-RE 96-channel Multi-Probe Head (MPH) allows for high-throughput, automated sample processing. Using the NIMBUS96 platform, two sample plates can be ready for LC-MS/MS injection in approximately 15 minutes.