Quantitation of Fentanyl, Norfentanyl, Buprenorphine, and Norbuprenorphine in Urine Using SCX-XTR Tips and LC-MS/MS

Fentanyl and buprenorphine are potent analgesics making them medicinally appealing and easy to abuse. Thus, they are two of the most common analytes monitored in clinical and forensic laboratories. Due to their high potency and low dosages, urinary concentrations are much lower than other common opiates/opioids. This leaves most laboratories struggling to increase the sensitivity and speed of their methods. This method, using DPX INTip™ technology with Strong Cation Exchange (SCX) sorbent, promotes an easy, fast, and sensitive method to help laboratories increase efficiency of detecting these compounds and their metabolites.