Pilot and Downstream Production
Applikationen
Receiver Tank
After a first filtration process, cell culture or fermentation broth are stored in the receiver tank for further purification of the target molecules.
Virus Inactivation
Virus Inactivation is an important process step to keep the viruses in a non-infective form in the media. There are 4 main technologies established to achieve this goal: Pasteurization, Solvent- or Detergent-, UV-C- and Low pH treatment. Lowering the pH value is an easy and fast method to treat even large volumes.
Centrifuge
Cells and debris are removed in the centrifuge in order to prepare the solution for further purification in downstream processing.
Buffer Preparation
Protein solutions are transferred to buffer systems appropriate for further downstream processing. The buffer systems need to be prepared and controlled carefully in order to obtain excellent purification results.
Ion Exchange Chromatography
Ion Exchange Chromatography is a workhorse in the separation of ions and charged molecules, i.e. proteins, nucleotides and amino acids. It's a major purification step in isolating target molecules. Depending on the type of target molecule anion-exchange and / or cation exchange chromatography is used.
Final Product
Prior to fomulation and filling the final product needs to be kept under perfect storage conditions.
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