RNA must be purified for many molecular biology experiments including PCR, gene expression profiling and RNA therapeutic research. Well-developed methods are currently available for the isolation and purification of RNA from a variety of sample types such as cells, tissues, serum, plasma and cell-free media. Viral RNA is particularly challenging to isolate from these samples due to low titers, large initial sample volume requirements to obtain the desired yield and the complexity of the samples themselves. In some cases, the procedure must also be compatible with downstream processes such as PCR. When performed manually, these assays can suffer from inconsistent sample processing, clogging and large elution volumes. Hamilton has developed an automated solution for RNA isolation from viruses using the Ambion MagMax Viral RNA Isolation Kit on the MICROLAB® STARlet Automated Liquid Handling Workstation.