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Microlab VANTAGE Liquid Handling System

Pipetting Evolution, Logistics Revolution

  • Simple assay programming & detailed 3-D simulation
  • Expandable, space saving design to meet changing
    lab’s needs
  • Large throughput and walkaway time with
    over 400 plate capacity
  • Minimized runtimes for all pipetting and
    transportation tasks

More Information

Need Help?  +1-775-858-3000

Integrated Simplicity

Once again, we have brought engineering and capability to the lab by simply developing the best instrument for the next decade. 

Features & Benefits

  • Simple assay programming and detailed 3-D simulation
  • Expandable, space-saving design to meet changing lab’s needs
  • Large throughput and walk-away time with over 400 plate capacity
  • Minimized runtimes for all pipetting and transportation task

INSTINCT V: Features & Benefits

INSTINCT V’s different editors allow every user to work with the VANTAGE Liquid Handling System with Clear 3D run visualization.

  • Dynamic Scheduler: Optimized scheduling for the shortest run time possible, even as new assays are added
  • CARE Technology: Contamination Avoidance Response enables tip disposal to avoid contamination with specified substances
  • Assay Editor: Simple, drag-and-drop graphical editor for assay programming
  • 3-D Simulation: Conveniently setup assays using your personal computer
  • Error Handling: Reduce downtime using the industry’s best recovery strategies
  • Setup Verification: Process control through labware detection and identification
  • Database Storage: Complete traceability of instrument, labware and sample data

Compressed O-Ring Expansion (CO-RE)

Many of today’s applications require precision in tip attachment and positioning. To accomplish this, Hamilton utilizes proprietary Compressed O-Ring Expansion (CORE) technology. CO-RE technology attaches disposable tips using a highly robust lock-and-key style mechanism. This enables a positional precision of + 0.1mm on all axes. The system requires virtually no vertical force for tip attachment or ejection, thus eliminating mechanical stress and minimizing the production of aerosols. Reduced stress also improves overall system reliability and throughput.

Anti-Droplet Control (ADC)

This technology serves to compensate in real time for pressure changes in the liquid channels caused by high vapor pressure of volatile solvents. Upon activation, ADC prevents inadvertent dripping from the channels, reducing the risk of contaminating the deck. ADC detects and reacts on pressure changes in the channels that are caused by the high vapor pressure of volatile solvents in real time. This feature is available with single pipetting channels.

Monitored Air Displacement (MAD)

By monitoring the air-based pipetting action, the VANTAGE Liquid Handling System can detect clots or empty wells during the aspiration step in real time. It can also be used to pipette highly volatile solvents. With MAD your pipetting robot gives you a feedback on the real-time tracking of the aspiration performance. Therefore MAD delivers a confirmation of the successful aspiration. Monitored Air Displacement eliminates uncertainty in automated assays by providing reliable, consistent walk-away automation.

Total Aspiration and Dispense Monitoring (TADM)

During crucial sample transfers (e.g. in vitro Diagnostics or DNA Forensics), parameters may be set to monitor, in real time, both the aspiration and dispense steps. TADM verifies with a traceable digital audit trail that a sample has been successfully transferred.

Liquid Level Detection (LLD)

The VANTAGE Liquid Handling System uses LLD technology to determine liquid levels in tubes and plates located on the pipetting deck. There are two modes of LLD: capacitative LLD (c-LLD), used to detect most types of liquids in most types of vessels; and pressure-based LLD (p-LLD), which can detect virtually all fluid types, including foaming liquids and non-conductive organic solvents. cLLD is available (MPH channels A1, B2, G11 & H12); pLLD is available. For even greater confidence in COMPRESSED O-RING EXPANSION (CO-RE) LLD, a dual mode LLD approach may be used.


 

VANTAGE Liquid Handling System Functional & Performance Specifications

Parameters Specifications
Physical Dimensions  
2.0 m Pipettor
Length:
Width:
Height:

79.0 in (200.7 cm)
36.4 in (92.5 cm)
31.9 in (81.0 cm)
1.3 m Pipettor
Length:
Width:
Height:

52.0 in (132.1 cm)
36.4 in (92.5 cm)
31.9 in (81.0 cm)
Pipettor height with door open
Height:

17.7 in (45.0 cm)
2.0 m Logistics Cabinet
Length:
Width:
Height:

79.0 in (200.7 cm)
36.4 in (92.5 cm)
39.0 in (99.1 cm)
1.3 m Logistics Cabinet
Length:
Width:
Height:

52.0 in (132.1 cm)
36.4 in (92.5 cm)
39.0 in (99.1 cm)
2.0 m Track Gripper
Length:
Width:
Height:

79.0 in (200.7 cm)
9.9 in (25.1 cm)
70.9 in (180.1 cm)
1.3 m Track Gripper
Length:
Width:
Height:

52.0 in (132.1 cm)
9.9 in (25.1 cm)
70.9 in (180.1 cm)
NanoPulse™ 1000 µL Channel Pipetting Specifications
Disposable tip size:

10 μL:
10 μL:
10 μL:
10 μL:
50 μL:
50 μL:
50 μL:
50 μL:
300 μL:
300 μL:
300 μL:
300 μL:
1000 μL:
1000 μL:
1000 μL:
1000 μL:

 

Volume

0.5 μL
1 μL
5 μL
10 μL
1 μL
5 μL
10 μL
50 μL
5 μL
10 μL
100 μL
300 μL
3 μL
5 μL
20 μL
1000 μL

Trueness
|R| (%)
5.0%;
3.5%
2.5%
1.0%
3.5%
2.5%
1.0%
1.0%;
5.0%
3.8%
1.5%
1.0%
6.5%
5.8%
4.9%
1.0%

Precision
CV (%)
6.0%
4.0%
2.0%
1.0%
4.0%
2.0%
1.0%
0.75%
3.7%
2.7%
2.0%
2.0%
4.5%
4.0%
3.4%
0.75%

*Pipetting results were achieved using Hamilton Verification Solution (HVS) and non-filtered, CO-RE conductive pipette tips at 24°C and 50% relative humidity. Data points at or below 10 µL were developed using NanoPulse Jet Dispense mode. Specifications may be invalid if any of the previously identified conditions are altered.

Standard 1000 µL Channel Pipetting Specifications
Disposable tip size:

10 μL:
10 μL:
10 μL:
50 μL:
50 μL:
50 μL:
300 μL:
300 μL:
300 μL:
1000 μL:

 

Volume

1 μL
5 μL
10 μL
1 μL
5 μL
50 μL
10 μL
100 μL
300 μL
1000 μL

Trueness
|R| (%)
5.0%
2.5%;
1.5%
5.0%
2.5%
1.5%
3.0%
1.5%
1.0%
1.0%

Precision
CV (%)
5.0%
2.0%
2.0%
5.0%
2.0%
0.75%
2.0%
2.0%
2.0%
0.75%

*Pipetting results were achieved using Hamilton Verification Solution (HVS) and non-filtered, CO-RE conductive pipette tips at 24°C and 50% relative humidity. Specifications may be invalid if any of the previously identified conditions are altered.

96-Channel CO-RE Head Pipetting Specifications
Disposable tip size:

10 μL:
10 μL:
10 μL:
50 μL:
50 μL:
50 μL:
300 μL:
300 μL:
300 μL:
1000 μL:

 

Volume

1 μL
5 μL
10 μL
1 μL
5 μL
50 μL
10 μL
100 μL
300 μL
1000 μL

Trueness
|R| (%)
5.0%
2.5%;
1.5%
5.0%
2.5%
1.5%
3.0%
1.5%
1.0%
1.0%

Precision
CV (%)
5.0%
2.0%
2.0%
5.0%
2.0%
0.75%
2.0%
2.0%
2.0%
0.75%

*Pipetting results were achieved using Hamilton Verification Solution (HVS) and non-filtered, CO-RE conductive pipette tips at 24°C and 50% relative humidity. Specifications may be invalid if any of the previously identified conditions are altered.

384-Channel CO-RE Head Pipetting Specifications
Disposable tip size:

50 μL
50 μL:
50 μL:
50 μL:
300 μL:

 

Volume

0.5 μL
1 μL
5 μL
10 μL
50 μL

Precision
CV (%)
6.0%
3.5%
3.0%
2.0%
2.0%


*Pipetting results were achieved using Hamilton Verification Solution (HVS) and non-filtered, CO-RE conductive pipette tips at 24°C and 50% relative humidity. Specifications may be invalid if any of the previously identified conditions are altered. ;

Plate Format

Microtiter SBS footprint
Plate height < 43 mm

Deck Capacity

2.0 m Pipettor: 65 SBS positions, 83 tracks
1.3 m Pipettor: 40 SBS positions, 53 tracks

Entry/Exit Magazine Capacity
(4 magazines per Entry/Exit module)

Standard Microtiter Plate
Deep-Well Microtiter Plate (2.2 mL)
Lidded Microplate (22 mm)
Nested Tip Racks
Random Access Std Microtiter Plate
Random Access Deep-Well Microtiter Plate
Random Access 10/50 µL tips
Random Access 300 µL tips
Random Access 1 mL tips
Random Access 300 µL Rocket tips



36 plates
11 plates
22plates
27 racks
8 plates
5 plates
7 tip frames
6 tip frames
4 tip frames
5 tip frames

Track Gripper

Absolute Specifications
Gripping Force
Transport Mass
Operational Width
Angle of Rotation

Accuracy: X,Y,Z = 0.5 mm; Reproducibility: X,Y,Z = 0.25 mm
16 N
310 g filled deep-well plate
69 – 135 mm
Wrist +/- 90°, Tower 360°

PC Requirements
*Please Note: PC requirements may differ depending on application and device integration.

Windows® 7 64 bit
CPU speed 2.7 GHz, 2 Processor cores
8 GB memory, 40 GB free space on hard disk
Ethernet and USB communication

CSA Certification

Installation category
Pollution degree

II
2

VANTAGE  Config

Pipettor

Pipetting Channels: You can choose between standard 1000 µL channels or NanoPulse™ 1000 µL channels for precise low volume pipetting from sub-microliter up to 1 milliliter within the same channel. The channels use Hamilton’s tip positioning system and each pipetting arm can be equipped with up to 8 pipetting channels (1000 μL) with 9 mm spacing.

Multi-Probe CO-RE: An optional Multi-Probe CO-RE Head may be added to the Pipetting Arm for multi-well plate applications. The following heads are available: 96 channel CO-RE head and 384 channel CO-RE head

Pipetting Arm: The pipetting arm moves the channels or Multi-Probe CO-RE Head in the X-direction. For higher throughput, you may place two arms on any 2.0 m platform or larger such that these arms work in parallel (e.g. while one arm is reserved for the pipetting tasks, the other arm can transfer plates onto the deck or to/from a peripheral device).

Main Door Lock : To preserve maximal safety, the housing of the VANTAGE Liquid Handling System is equipped with sensors and door locks.

Loading Tray: During the loading process, the tray’s LED lights indicate the placement of carriers on the workspace.

ID Loading Service: To maintain the chain of custody, the ID Loading Device not only reads 1D and 2D Barcodes of carriers and samples, but also recognizes if a labware is located at its expected position. This gives the Scheduler additional freedom in optimizing the plan and offers you the convenience of a fully-tracked process.

Internal Plate Gripper (optional): An optional Internal Plate Gripper may be added to the Pipetting Arm for additional on-deck transportation of labware.

Logistics Cabinet

Entry/Exit : Each Entry/Exit can hold up to four magazines.  One standard magazine can hold stacked microtiter plates or nested tip racks per the specification.  The module also can be equipped with shelves for random access.  A barcode accessory on the Entry/Exit tracks all inventory.

Configurable Waste: Customizable solid and liquid waste options are easily accessible and allow you to separate waste according to contamination (biohazard) or waste type. All waste compartments contain sensors to monitor the fill state and notify the user whenever action is required.

AC Box: The AC Box controls the power management of the instrument and all third party devices integrated.  Different sizes are available depending on the scale of the integration.

Cabinet Door Lock: To preserve maximal safety, the housing of the VANTAGE, including the Logistics Cabinet, is equipped with sensors and door locks.

Track Gripper

The Track Gripper is a transportation device of the VANTAGE Liquid Handling System. This telescopic gripper can be added to the rear of any system containing a Pipettor and Logistics Cabinet and transports labware and consumables independently of the Pipetting Arm and Internal Plate Gripper. The Track Gripper uses smart collision control to maximize movement over the entire pipetting workspace as well as to and from third-party devices on, below and behind the workspace.

Rear Integration Cabinet

The VANTAGE Liquid Handling System Rear Integration Cabinet module is a full-height integration space. It may be added to any system containing a Pipettor, Logistics Cabinet and Track Gripper, and is for the integration of third-party devices, Entry/Exits or waste modules.

Module Integration

The VANTAGE Liquid Handling System is available in two main platform sizes: 2.0 m and 1.3 m.
VANTAGE Liquid Handling System's unique scalability can accommodate the widest possible range of throughputs and budgets.  Additional pipetting channels, a 96- or 384-probe head or an integrated robotic arm can be fitted to existing configurations. You can even add a second pipetting arm to work in parallel.