Benefits of Solid-State DCO₂ Measurement
No liquids or replacement parts to change.
In air and gas standard.
Designed for bioproduction (5–1000 mbar).
Compatible with Autoclave, SIP, or CIP.
Excessive Accumulation (Too High)
During a process excess CO₂ accumulation is common as cell concentration increases and more metabolic CO₂ is produced. This accumulation reduces intracellular pH resulting in slower enzymatic activity or delayed lactate shift. The outcome is lower production quantity and quality.
Excessive Removal (Too Low)
Aggressive aeration and mixing can prevent detrimental accumulation of CO₂. However, too little CO₂ can slow cell growth, metabolism, and productivity by starving cells of CO₂ needed for the formation of metabolic intermediates. Excessive removal can also reduce buffer capacity in bicarbonate systems.
Uncontrolled CO₂ Range (Uncontrolled)
Media addition and process adjustments can result in large swings in dissolved CO₂ that may go unnoticed with infrequent offline monitoring and adjustment. Continuous inline control at the optimal level yields increased viable cell density, production phase duration, and titer.
Sign up to see the launch webinar on demand
Hamilton's latest solid-state sensor offers a new breed of dissolved carbon dioxide (DCO₂) sensor, specifically made for bioreactors.
Sign up for our special launch webinar and learn more about:
- What is missing from current measurement DCO₂ measurement technologies, like Severinghaus sensors and blood gas analyzers (BGAs)?
- How can solid-state, optical measurement decrease operational cost?
- Giovanni Campolongo, Market Segment Manager, Biopharma
Thanks to his experience in the field of sensor technology and GMP compliance, Giovanni focuses on PAT (process analytical technology) solutions and their applications in regulated environments.
- Kelsey Mato, Market Segment Manager
An analytical chemist by training, Kelsey leads the applications team for Hamilton's US operations. She received her Ph.D from Louisiana State University.