Incyte is a permittivity sensor whose reading can be correlated to the viable cell density. This sensor has been proven across many cell lines and microorganisms: from mammalian and insect cell culture to high density bacterial, yeast or filamentous fungi fermentation. Check out the Cell Density Applications eBook for real data. This real-time sensor can be used directly in the cell culture process, or fermentation for real-time process control, eliminating the need for offline sampling and analysis.

How does Incyte work?

Incyte applies an alternating electric field to the culture and measures the resulting polarization and depolarization of living cells and microorganisms through a permittivity reading (capacitance per area). This signal can be correlated to the viable cell density, because only viable cells can be polarized. Dead cells have a leaky membrane and cannot be polarized. This method is therefore insensitive to dead cells, cell debris, and microcarriers.

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Accessories for Incyte Sensors

A measuring loops consist of an Incyte sensor and a pre-amplifier, which are factory calibrated. The Sensor Unit is connected to a Cell Density Controller and provides a variety of communication protocols, from analog 4-20 mA signal to digital OPC-XML-DA connection. Diverse accessories are available to complete the portfolio.

Specific Applications

Resources

Hamilton's knowledge base provides a range of explanatory articles, frequently asked questions, and document downloads.
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