Total Cell Density Sensors - Dencytee
Total cell density measurement by the Dencytee sensor is based on the optical density, the turbidity of a suspension at NIR wavelengths. All particles and molecules that scatter the NIR light will be detected and can be correlated to the total cell density measured offline. The Dencytee sensor increases the light intensity as turbidity rises leading to a wide measuring range.
How does Dencytee work?
Dencytee measures the turbididty at NIR (near infra-red) wavelengths so it is insensitive to changes in media color. All particles that scatter light at 880 nm will be detected, including living and dead cells.
Accessories for Dencytee Sensors
A measuring loops consist of an Dencytee sensor and a pre-amplifier, which are factory calibrated. The Sensor Unit is connected to a Cell Density Controller and provides a variety of communication protocols, from analog 4-20 mA signal to digital OPC-XML-DA connection. Diverse accessories are available to complete the portfolio.
Cell Density Controllers and Accessories
Cell Density Cables
Dencytee Sensor Maintenance
Specific Applications
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App Note - Real-time cell density measurement for PAT applications
An application highlighting the use of Incyte and Dencytee in a PAT approach to monoclonal antibody (mAb) production. -
App Note - Online monitoring of CHO cell culture
A suite of Hamilton sensors is used to continuously monitor batch fermentation of CHO cells for tighter process control. -
App Note - Real-time total cell density measurement of yeast fermentations
Dencytee is used to optimize fermentation conditions for yeast processing.
Resources
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Support Resource - Incyte Data Analysis Macro
Import offline data from the offline data worksheet and Incyte data into this macro for automatic generation of data analysis graphs. -
Support Resource - Incyte Protocol for Offline Measurement Correlation (Demo Protocol)
This guide details how to obtain the relevant offline measurements and online Incyte (permittivity) data of viable cell density to establish a correlation. -
Infographic - Online Cell Density
An infographic highlighting the use and benefits of on-line cell density measurement.
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