Hamilton Syringe Grant Testimonials
Neuroscience
Ultrasound Guided Injection of Tumor Cells into Mice
A less invasive technique that allows for a shorter recovery time and potentially faster turnaround times for studies.
Normal and Cerebrospinal Fluid Physiology of the Spinal Cord
A study of the mechanism of fluid inflow and outflow from the spinal cord.
Relationship Between Dysfunction in the Brain and Behavior
Determining the role dopamine plays in a rodent's ability to react with fear to a threatening stimulus.
Molecularly-Induced Functional Changes Within the Nervous System
Molecularly-induced functional changes within the nervous system in various disease states.
Identification of Causative Mechanism(s) in the Pathology of Alzheimer's Disease
Therapeutically target to slow the onset and/or development of the pathology of AD.
Developing Novel Therapeutics for Childhood Spinal Muscular Atrophy
The laboratory of Professor Thomas Gillingwater at the University of Edinburgh is developing novel therapeutics for the treatment of Spinal Muscular Atrophy (SMA).
Altering miRNA and lncRNA Expression in Mice
Hamilton Neuros syringes will be used for intrauterine injections into fetal brain matter to alter miRNA and lncRNA expression at embryonic day 14 in the mouse.
DREADDS and A Neural Basis of Alcohol Drinking
Work in the Behavioral Neuroscience laboratory at Boston College could be the first to show that amygdala activity is necessary for alcohol drinking.
Novel Research on Metalloproteins
Students in the Wilcox lab at Dartmouth College use isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) to conduct research and learn about thermodynamics.
Pioneering a New Technique to Study Migraine Headaches
Carolina Burgos-Vega and the University of Texas at Dallas pioneers a new technique for stimulating the meninges in order to study the pathophysiology of migraine headache.
Metal/Amino Acid Complexes Show Activity Against Bacterial Infection
Joseph S. Merola establishes a research program at Virginia Tech to study metal complexes of amino acids.
Nitrogen Solubility in Marine Animals
Fatty acid analysis of animal tissues and measuring the solubility of nitrogen gas in oils extracted from the tissues of diving animals.
Effects of Cocaine on Synapses in the Brain
Stereotaxic injections of adeno-associated virus into mouse brains.
How the Brain Controls Metabolic Diseases Such as Obesity and Type-2 Diabetes
Stereotaxically administer a highly precise amount of virus into specific regions of a rodent brain.
Investigating Central Mechanisms Augmenting the Development of Post-Menopausal Hypertension
Investigation Through Excising Different Receptors In The Brain By Injecting A CRE Virus
Energy Metabolism of The Heart
Studying Heart Mitochondria In Animal Models Of Heart Disease, In Human Heart Samples From Transplant Patients, Or In Normal Heart Using High-Resolution Respirometry (HRR) Using An Oxygraph
Effects on the Visual System
Creating a chemically induced model of glaucoma and macular degeneration to observe the downstream effects on the visual system.
Using Viral Vectors to Research Microcircuits Within Distinct Brain Regions
Understanding how the orexin system regulates stress-induced behaviors through the basolateral amygdala.
Cellular and Neural Circuitry Studies of Changes in Animal Models of Parkinson's Disease with Viral Vectors
Selectively express specific genes in given brain regions in order to carry out optogenetic, chemogenetic, or genetic experiments.
Research in Electrophysiology, Calcium Imaging, and Other in Vivo Experiments
Studies using viral stereotaxic injections in mice.
Understanding How Disruptions to Inhibitory Signaling in the Brain Lead to Network Dysfunction Underlying Neurological Diseases
Introducing guide RNAs or DREADDS while performing small rodent stereotaxic surgeries.
Microfluidic Cell Separation Technique
By precisely controlling the flow rate in the microchannels, the cells' trajectories can be manipulated by the balance of inertial hydrodynamic forces.
Life Science
FGF Signaling in Craniofacial Development of Mice
Injection of small volumes of solution into newborn to early-postnatal mice.
Using Nanotechnology to Improve the Dialysis Process
Probing defects less than one nanometer in membranes that are only one atom thick using simple, table top experiments.
Analyzing Mitochondrial Oxidative Capacity and Efficiency in Human Heart Tissue
Investigating The Contractile Force And Kinetics Of Contraction And Relaxation of Non-Failing And End-Stage Failing Hearts.
Diagnostics and Therapeutic Approaches to Fight Inherited Blindness
Understanding the biochemistry of visual cycle and the etiology of human blinding retinopathies.
Electrospray MS of Acetogenins from Butterflies
Using LC MS/MS to identify biologically active compounds in different butterfly species.
Developing Ultrasound Localization Microscopy for Neuro and Cardiovascular Imaging
This imaging modality is based on the injection of microbubbles tracked with ultrasound imaging for the extraction of the 3D vascularization of organs.
Evaluating Procedures for Cleaning Birds and Other Wildlife Affected by Oil Spills
GC analysis of residual crude oil to optimize the cleaning of feathers for birds affected by oil spills.
Accurate Implantation of Osteosarcoma Cells Intratibially
Creating orthotopic patient derived xenograft models of pediatric osteosarcoma for treatment with novel therapies.
CRISPR-Based Genome Editing for Breast Cancer Research
Injection of viral microvolumes into CRISPR-based gene edited mice to in-vivo model breast cancer and the role of specific acid-base regulators in the diseases' development.
Precision Micro-injections in Invertebrate Models for Innate Immunity Experiments
Precise micro-injections provided by Hamilton Syringes aid in innate immunity experiments in small invertebrate model Galleria mellonella.
Biology
Microfluidic assisted production of polymeric and lipidic nanoparticles
Utilizing microfluidic technology for polymeric and lipid nanoparticular drug delivery systems.
Optimizing Production of Algal Biofuels
Screening a knockout mutant library of the model algae, Chlamydomonas reinhardtii, to identify genes that affect lipid production.
Inspecting Erythrocyte Physiology to Uncover Novel Biochemical and Physical Properties of Blood Cells
Enhancing blood compatibility with medical heart-lung machines.
Linking Circadian Rhythms and Mental Health
Manipulating neuronal circuits to investigate the physiological basis of behavior.
Understanding How Microbes Affect Earth's Biogeochemical Cycling
Measuring bulk and clumped isotopic compositions of methane molecules derived from various microbial pathways.
Maximizing Yields Using Fast Protein Liquid Chromatography (FLPC)
Combining structural, biochemical, and biophysical approaches to understand the molecular mechanisms of the proteins responsible for transmitting matter.
Using High Resolution Respirometry to Evaluate Mitochondrial Function Across Species and Disease States
Using the oxygraph-2k system (Oroboros Instruments, Austria) to develop and carry out individualized substrate, uncoupler, inhibitor, titration protocols using Hamilton syringes.
Intramuscular Injection of CRISPR Solution in Xiphophorus Fishes
Elucidating the molecular and genetic regulator of melanoma in Xiphophorus fishes with translational potential.
Insect Reproduction Using RNAi Methodologies
Using dsRNA to identify gene function by depleting the expression of the mRNAs codified by these genes.
Identifying Cellular and Molecular Changes Associated with Chronic Osteoarthritis Pain
Injecting AAV vectors to conduct in vivo imaging of nerves that innervate the knee joint to study how they change in osteoarthritis.
General Science
Food Science Research
Prevention and control of foodborne infections by the Purdue University Food Science Lab with an emphasis on molecular and genetic basis of virulence of foodborne pathogens and host parasite interactions.
Unique Nutrition Laboratory
Experimental Nutrition course from the University of Minnesota offers a biochemically focused course researching colon cancer and diabetes/obesity.
Sustainable Energy and Environmental Applications
Sustainable design of visible light-driven photocatalytic systems for harnessing solar energy, hydrogen evolution, and efficient degradation of emerging water contaminants.
Air-Sensitive Chemistry Research
Undergraduate students gain skills in air-free chemistry techniques as preparation for their future graduate studies or careers in chemical industry.
Nano Crystals and Their Application in Industry
Studying the synthesis of semiconducting nanocrystals.
Nested Needle Block
Nested needle block for use in an advanced and high throughput acoustofluidics system.
Studying Synthetic Polymers for Enhancing Recycling and Biodegradability of Plastics
The University of Akron's Polymer Science Dept. prefers Hamilton products to perform polymer synthesis, catalysis and air-sensitive reactions.
Understanding Reactivity Profiles of Bioinspired Catalysts
Simon Fraser University uses Hamilton syringes for in-depth analysis of reaction processes.
Solving Molecular Puzzles with Mass Spectrometry and Allied Techniques
Using Hamilton syringes to introduce samples for analysis by electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI) mass spectrometry.
Studying Modern Biophysical Chemistry Methods
Relying on Hamilton Gastight syringes for accurate results with techniques such as absorbance, fluorescence and infared spectroscopy.
Investigating Gas Exchange Driven by Mechanochemistry - From Subglacial Ecosystems to the Martian Regolith
Routine use of Hamilton syringes and needles in the Planetary Science group at Newcastle University.
Hypersaturation of Nitric Oxide (NO) Gas in a Gel-Type Polymer
Hamilton Gastight syringes will get the job done without loss of nitric oxide (NO) gas.
Synthesis of Nature-Inspired Polymer and Evaluating Their Self-Assembled Hierarchical Nanostructure
Using gel permeation or size exclusion chromatography (GPC/SEC) to determine the average molar mass and dispersity of synthesized polymers.
Measuring CO2 Solubility and Diffusivity in Hydrocarbon Oils
Developing a simple microfluidics-based gas solubility and diffusivity measurement technique that can be used by the scientific community.
Water Harvesting through Microdroplets
Developing novel strategies for atmospheric water harvesting to augment the supply of drinking water.
Performing Extractions and Sample Preparation for Quantitative NMR Analysis
The reliability and accuracy of Hamilton products will ensure that sample preparation methods are robust and capable of properly quantifying unknowns by minimizing volumetric variability.
Studying the Biochemistry and Microbiology of Anoxic Sediments and Aquatic Environments
Researching the degradation of the seldom researched gas dimethylsulfide (DMS) in sediments lacking oxygen (anoxic).
Researching Microfluidic Devices and Polymer Solutions to Develop Optimized Technologies
Researching the degradation of the seldom researched gas dimethylsulfide (DMS) in sediments lacking oxygen (anoxic).
Neat Distillation Column Products Analysis
Education
Cerritos Community College Excels With High Standards of Teaching
At Cerritos Community College, 40% of students achieve 90th percentile or above when taking the national American Chemical Society standardized exam.
Relevant Research Opportunities
University of Manitoba supports multiple undergraduate and graduate research opportunities with Hamilton Grant.
A Student’s Grade Depended on Hamilton Precision
At Wilkes University, the precision of Hamilton Syringes helps students conserve and precisely apply expensive reagents in a micro scale environment experiment.
Providing Students with Hands-On Laboratory Experiences with Modern Instrumentation
Walsh University has a distinctive science program which provides meaningful laboratory experiences that will better prepare students for post-bachelor careers.