Neuroscience

Hamilton Grant Testimonial

Ultrasound Guided Injection of Tumor Cells into Mice

A less invasive technique that allows for a shorter recovery time and potentially faster turnaround times for studies.
Hamilton Grant Testimonial

Normal and Cerebrospinal Fluid Physiology of the Spinal Cord

A study of the mechanism of fluid inflow and outflow from the spinal cord.
Hamilton Grant Testimonial

Relationship Between Dysfunction in the Brain and Behavior

Determining the role dopamine plays in a rodent's ability to react with fear to a threatening stimulus.
Hamilton Grant Testimonial

Molecularly-Induced Functional Changes Within the Nervous System

Molecularly-induced functional changes within the nervous system in various disease states.
Hamilton Testimonials

Identification of Causative Mechanism(s) in the Pathology of Alzheimer's Disease

Therapeutically target to slow the onset and/or development of the pathology of AD.
Hamilton Grant Testimonial

Developing Novel Therapeutics for Childhood Spinal Muscular Atrophy

The laboratory of Professor Thomas Gillingwater at the University of Edinburgh is developing novel therapeutics for the treatment of Spinal Muscular Atrophy (SMA).

Altering miRNA and lncRNA Expression in Mice

Hamilton Neuros syringes will be used for intrauterine injections into fetal brain matter to alter miRNA and lncRNA expression at embryonic day 14 in the mouse.
Hamilton Testimonials

DREADDS and A Neural Basis of Alcohol Drinking

Work in the Behavioral Neuroscience laboratory at Boston College could be the first to show that amygdala activity is necessary for alcohol drinking.

Novel Research on Metalloproteins

Students in the Wilcox lab at Dartmouth College use isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) to conduct research and learn about thermodynamics.
Hamilton Grant Testimonials

Pioneering a New Technique to Study Migraine Headaches

Carolina Burgos-Vega and the University of Texas at Dallas pioneers a new technique for stimulating the meninges in order to study the pathophysiology of migraine headache.
Hamilton Grant Testimonial

Metal/Amino Acid Complexes Show Activity Against Bacterial Infection

Joseph S. Merola establishes a research program at Virginia Tech to study metal complexes of amino acids.
Hamilton Grant Testimonial

Nitrogen Solubility in Marine Animals

Fatty acid analysis of animal tissues and measuring the solubility of nitrogen gas in oils extracted from the tissues of diving animals.
Hamilton Grant Testimonials

Effects of Cocaine on Synapses in the Brain

Stereotaxic injections of adeno-associated virus into mouse brains.
Hamilton Grant Testimonial

How the Brain Controls Metabolic Diseases Such as Obesity and Type-2 Diabetes

Stereotaxically administer a highly precise amount of virus into specific regions of a rodent brain.
Hamilton Testimonials

Investigating Central Mechanisms Augmenting the Development of Post-Menopausal Hypertension

Investigation Through Excising Different Receptors In The Brain By Injecting A CRE Virus
Hamilton Grant Testimonial

Energy Metabolism of The Heart

Studying Heart Mitochondria In Animal Models Of Heart Disease, In Human Heart Samples From Transplant Patients, Or In Normal Heart Using High-Resolution Respirometry (HRR) Using An Oxygraph
Hamilton Grant Testimonial

Effects on the Visual System

Creating a chemically induced model of glaucoma and macular degeneration to observe the downstream effects on the visual system.
Hamilton Grant Testimonial

Using Viral Vectors to Research Microcircuits Within Distinct Brain Regions

Understanding how the orexin system regulates stress-induced behaviors through the basolateral amygdala.
Hamilton Testimonials

Cellular and Neural Circuitry Studies of Changes in Animal Models of Parkinson's Disease with Viral Vectors

Selectively express specific genes in given brain regions in order to carry out optogenetic, chemogenetic, or genetic experiments.
Hamilton Grant Testimonial

Research in Electrophysiology, Calcium Imaging, and Other in Vivo Experiments

Studies using viral stereotaxic injections in mice.
Hamilton Grant Testimonial

Understanding How Disruptions to Inhibitory Signaling in the Brain Lead to Network Dysfunction Underlying Neurological Diseases

Introducing guide RNAs or DREADDS while performing small rodent stereotaxic surgeries.

Microfluidic Cell Separation Technique

By precisely controlling the flow rate in the microchannels, the cells' trajectories can be manipulated by the balance of inertial hydrodynamic forces.
Hamilton Grant Testimonial

Skin Bacteria on Mosquito-Borne Viruses at the Vector-Host Skin Interface

In search of novel concepts and strategies to block mosquito-borne virus transmission and disease.

Life Science

Hamilton Grant Testimonia

FGF Signaling in Craniofacial Development of Mice

Injection of small volumes of solution into newborn to early-postnatal mice.
Hamilton Grant Testimonial

Using Nanotechnology to Improve the Dialysis Process

Probing defects less than one nanometer in membranes that are only one atom thick using simple, table top experiments.
Hamilton Testimonial

Analyzing Mitochondrial Oxidative Capacity and Efficiency in Human Heart Tissue

Investigating The Contractile Force And Kinetics Of Contraction And Relaxation of Non-Failing And End-Stage Failing Hearts.
Hamilton Testimonials

Diagnostics and Therapeutic Approaches to Fight Inherited Blindness

Understanding the biochemistry of visual cycle and the etiology of human blinding retinopathies.
Electrospray MS of Acetogenins from Butterflies

Electrospray MS of Acetogenins from Butterflies

Using LC MS/MS to identify biologically active compounds in different butterfly species.
Developing Ultrasound Localization Microscopy for Neuro and Cardiovascular Imaging

Developing Ultrasound Localization Microscopy for Neuro and Cardiovascular Imaging

This imaging modality is based on the injection of microbubbles tracked with ultrasound imaging for the extraction of the 3D vascularization of organs.
Evaluating Procedures for Cleaning Birds and Other Wildlife Affected by Oil Spills

Evaluating Procedures for Cleaning Birds and Other Wildlife Affected by Oil Spills

GC analysis of residual crude oil to optimize the cleaning of feathers for birds affected by oil spills.
Accurate Implantation of Osteosarcoma Cells Intratibially

Accurate Implantation of Osteosarcoma Cells Intratibially

Creating orthotopic patient derived xenograft models of pediatric osteosarcoma for treatment with novel therapies.
Hamilton Testimonials

CRISPR-Based Genome Editing for Breast Cancer Research

Injection of viral microvolumes into CRISPR-based gene edited mice to in-vivo model breast cancer and the role of specific acid-base regulators in the diseases' development.
Hamilton Grant Testimonial

Precision Micro-injections in Invertebrate Models for Innate Immunity Experiments

Precise micro-injections provided by Hamilton Syringes aid in innate immunity experiments in small invertebrate model Galleria mellonella.
Hamilton Grant Testimonial

Radioimmunotherapy of an Induced Spondylodiscitis in a Rat's Tail

Inducing a spondylodiscitis in a rat’s tail and evaluating infection eradication with radio labeled antibodies.
Hamilton Grant Testimonial

Specific spiking of small water volumes in freeze-dried protein formulations

Precisely controlling residual moisture to enhance stability of freeze-dried biopharmaceuticals.
Hamilton Grant Testimonial

Unlocking the Power of Supramolecular Noodles

Applying the power of low molecular weight gelators as supramolecular noodles in the fields of cell culture, optoelectronics, and regenerative medicine.
Harnessing the Power of Vaccines Through Strategic Dosing & Vaccination Site Research

Harnessing the Power of Vaccines Through Strategic Dosing & Vaccination Site Research

Focusing on the discovery of new and improved vaccine platforms.
Hamilton Grant Testimonial

Enabling Self-Administration Of Intradermal Vaccine With Passive Microfluidic Patch

Utilizing passive microfluidics for more efficient and less costly low-dose vaccinations via intradermal vaccine delivery.

Biology

Hamilton Grant Testimonial

Microfluidic assisted production of polymeric and lipidic nanoparticles

Utilizing microfluidic technology for polymeric and lipid nanoparticular drug delivery systems.

Optimizing Production of Algal Biofuels

Screening a knockout mutant library of the model algae, Chlamydomonas reinhardtii, to identify genes that affect lipid production.
Hamilton Grant Testimonial

Inspecting Erythrocyte Physiology to Uncover Novel Biochemical and Physical Properties of Blood Cells

Enhancing blood compatibility with medical heart-lung machines.
Hamilton Grant Testimonial

Linking Circadian Rhythms and Mental Health

Manipulating neuronal circuits to investigate the physiological basis of behavior.
Hamilton Grant Testimonial

Understanding How Microbes Affect Earth's Biogeochemical Cycling

Measuring bulk and clumped isotopic compositions of methane molecules derived from various microbial pathways.
Hamilton Grant Testimonial

Maximizing Yields Using Fast Protein Liquid Chromatography (FLPC)

Combining structural, biochemical, and biophysical approaches to understand the molecular mechanisms of the proteins responsible for transmitting matter.
Hamilton Grant Testimonial

Using High Resolution Respirometry to Evaluate Mitochondrial Function Across Species and Disease States

Using the oxygraph-2k system (Oroboros Instruments, Austria) to develop and carry out individualized substrate, uncoupler, inhibitor, titration protocols using Hamilton syringes.

Intramuscular Injection of CRISPR Solution in Xiphophorus Fishes

Elucidating the molecular and genetic regulator of melanoma in Xiphophorus fishes with translational potential.

Insect Reproduction Using RNAi Methodologies

Using dsRNA to identify gene function by depleting the expression of the mRNAs codified by these genes.
Hamilton Grant Testimonial

Identifying Cellular and Molecular Changes Associated with Chronic Osteoarthritis Pain

Injecting AAV vectors to conduct in vivo imaging of nerves that innervate the knee joint to study how they change in osteoarthritis.
Hamilton Grant Testimonial

Enabling Self-Administration Of Intradermal Vaccine With Passive Microfluidic Patch

Utilizing passive microfluidics for more efficient and less costly low-dose vaccinations via intradermal vaccine delivery.

Plant Biology

General Science

Food Science Research

Prevention and control of foodborne infections by the Purdue University Food Science Lab with an emphasis on molecular and genetic basis of virulence of foodborne pathogens and host parasite interactions.
Hamilton Grant Testimonial

Unique Nutrition Laboratory

Experimental Nutrition course from the University of Minnesota offers a biochemically focused course researching colon cancer and diabetes/obesity.
Hamilton Grant Testimonial

Sustainable Energy and Environmental Applications

Sustainable design of visible light-driven photocatalytic systems for harnessing solar energy, hydrogen evolution, and efficient degradation of emerging water contaminants.
Evaluating Procedures for Cleaning Birds and Other Wildlife Affected by Oil Spills

Air-Sensitive Chemistry Research

Undergraduate students gain skills in air-free chemistry techniques as preparation for their future graduate studies or careers in chemical industry.
Hamilton Grant Testimonial

Nano Crystals and Their Application in Industry

Studying the synthesis of semiconducting nanocrystals.

Nested Needle Block

Nested needle block for use in an advanced and high throughput acoustofluidics system.
Hamilton Grant Testimonial

Studying Synthetic Polymers for Enhancing Recycling and Biodegradability of Plastics

The University of Akron's Polymer Science Dept. prefers Hamilton products to perform polymer synthesis, catalysis and air-sensitive reactions.
Hamilton Grant Testimmonial

Understanding Reactivity Profiles of Bioinspired Catalysts

Simon Fraser University uses Hamilton syringes for in-depth analysis of reaction processes.
Hamilton Grant Testimonial

Solving Molecular Puzzles with Mass Spectrometry and Allied Techniques

Using Hamilton syringes to introduce samples for analysis by electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI) mass spectrometry.

Studying Modern Biophysical Chemistry Methods

Relying on Hamilton Gastight syringes for accurate results with techniques such as absorbance, fluorescence and infared spectroscopy.
Hamilton Grant Testimonial

Investigating Gas Exchange Driven by Mechanochemistry - From Subglacial Ecosystems to the Martian Regolith

Routine use of Hamilton syringes and needles in the Planetary Science group at Newcastle University.

Hypersaturation of Nitric Oxide (NO) Gas in a Gel-Type Polymer

Hamilton Gastight syringes will get the job done without loss of nitric oxide (NO) gas.
Hamilton Grant Testimonial

Synthesis of Nature-Inspired Polymer and Evaluating Their Self-Assembled Hierarchical Nanostructure

Using gel permeation or size exclusion chromatography (GPC/SEC) to determine the average molar mass and dispersity of synthesized polymers.
Hamilton Grant Testimonial

Measuring CO2 Solubility and Diffusivity in Hydrocarbon Oils

Developing a simple microfluidics-based gas solubility and diffusivity measurement technique that can be used by the scientific community.
Hamilton Grant Testimonial

Water Harvesting through Microdroplets

Developing novel strategies for atmospheric water harvesting to augment the supply of drinking water.
Hamilton Grant Testimonial

Performing Extractions and Sample Preparation for Quantitative NMR Analysis

The reliability and accuracy of Hamilton products will ensure that sample preparation methods are robust and capable of properly quantifying unknowns by minimizing volumetric variability.
Hamilton Grant Testimonial

Studying the Biochemistry and Microbiology of Anoxic Sediments and Aquatic Environments

Researching the degradation of the seldom researched gas dimethylsulfide (DMS) in sediments lacking oxygen (anoxic).
Hamilton Grant Testimonial

Researching Microfluidic Devices and Polymer Solutions to Develop Optimized Technologies

Researching the degradation of the seldom researched gas dimethylsulfide (DMS) in sediments lacking oxygen (anoxic).

Neat Distillation Column Products Analysis

Hamilton Testimonial

Droplet Coalescence Study

Researching the coalescence of microliter droplets that would not otherwise be possible on Earth through the utilization of a series of parabolic flights.

Kinetic Modeling of Hydrothermal Carbonization for a Waste-to-Energy Economy

Education

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